GB1382766A - Complex of 7-dimethylamino-6-demethyl-6-deoxytetracycline hydro- chloride - Google Patents
Complex of 7-dimethylamino-6-demethyl-6-deoxytetracycline hydro- chlorideInfo
- Publication number
- GB1382766A GB1382766A GB704473A GB704473A GB1382766A GB 1382766 A GB1382766 A GB 1382766A GB 704473 A GB704473 A GB 704473A GB 704473 A GB704473 A GB 704473A GB 1382766 A GB1382766 A GB 1382766A
- Authority
- GB
- United Kingdom
- Prior art keywords
- complex
- demethyl
- dimethylamino
- deoxytetracycline
- minocycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title abstract 4
- WTJXVDPDEQKTCV-UHFFFAOYSA-N 4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide;hydron;chloride Chemical compound Cl.C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2C1CC1C(N(C)C)C(=O)C(C(N)=O)=C(O)C1(O)C2=O WTJXVDPDEQKTCV-UHFFFAOYSA-N 0.000 abstract 4
- 229960002421 minocycline hydrochloride Drugs 0.000 abstract 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 3
- 239000001110 calcium chloride Substances 0.000 abstract 3
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 238000005649 metathesis reaction Methods 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 150000003841 chloride salts Chemical class 0.000 abstract 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 abstract 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N hydrofluoric acid Substances F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960004023 minocycline Drugs 0.000 abstract 1
- QPJSUIGXIBEQAC-UHFFFAOYSA-N n-(2,4-dichloro-5-propan-2-yloxyphenyl)acetamide Chemical compound CC(C)OC1=CC(NC(C)=O)=C(Cl)C=C1Cl QPJSUIGXIBEQAC-UHFFFAOYSA-N 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/252,175 US4038315A (en) | 1972-05-11 | 1972-05-11 | Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1382766A true GB1382766A (en) | 1975-02-05 |
Family
ID=22954914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB704473A Expired GB1382766A (en) | 1972-05-11 | 1973-02-13 | Complex of 7-dimethylamino-6-demethyl-6-deoxytetracycline hydro- chloride |
Country Status (21)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4837030A (en) * | 1987-10-06 | 1989-06-06 | American Cyanamid Company | Novel controlled release formulations of tetracycline compounds |
| USRE40183E1 (en) | 1991-10-04 | 2008-03-25 | Wyeth Holdings Corporation | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| CN1893956A (zh) * | 2003-07-25 | 2007-01-10 | 沃纳奇尔科特公司 | 多西环素金属络合物固体剂型 |
| NZ556582A (en) * | 2005-01-21 | 2010-12-24 | Warner Chilcott Co Llc | A tetracycline metal complex in a solid dosage form |
| PE20061107A1 (es) | 2005-03-14 | 2006-12-08 | Wyeth Corp | Composiciones de tigeciclina y metodos para su preparacion |
| AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
| AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
| AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| US20090099376A1 (en) * | 2007-10-16 | 2009-04-16 | Wyeth | Tigecycline and methods of preparing intermediates |
| EP2406213A1 (en) | 2009-03-12 | 2012-01-18 | Wyeth LLC | Nitration of tetracyclines |
| JP6025712B2 (ja) | 2010-05-12 | 2016-11-16 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | テトラサイクリン組成物 |
| PT106063B (pt) * | 2011-12-19 | 2017-05-30 | Inst Superior Técnico | Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono |
| CN104356021B (zh) * | 2014-10-15 | 2016-04-20 | 江西国药有限责任公司 | 一种注射级土霉素碱的提纯工艺 |
| CN108218738A (zh) * | 2018-03-21 | 2018-06-29 | 宁夏泰瑞制药股份有限公司 | 一种盐酸米诺环素的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA535471A (en) * | 1957-01-08 | Heinemann Bernard | Therapeutically useful tetracycline complex | |
| US2903395A (en) * | 1956-03-30 | 1959-09-08 | Pfizer & Co C | Aqueous calcium dioxytetracycline antibiotic composition |
| US3586483A (en) * | 1968-10-14 | 1971-06-22 | American Cyanamid Co | Method for detecting the presence of tetracycline antibiotics |
-
1972
- 1972-05-11 US US05/252,175 patent/US4038315A/en not_active Expired - Lifetime
-
1973
- 1973-01-24 ZA ZA730517A patent/ZA73517B/xx unknown
- 1973-01-25 AU AU51453/73A patent/AU469300B2/en not_active Expired
- 1973-01-26 PH PH14288*A patent/PH10297A/en unknown
- 1973-01-31 CA CA162563A patent/CA986510A/en not_active Expired
- 1973-02-06 AR AR246431A patent/AR196326A1/es active
- 1973-02-13 GB GB704473A patent/GB1382766A/en not_active Expired
- 1973-02-26 DE DE2309582A patent/DE2309582C3/de not_active Expired
- 1973-02-27 SU SU7301887629A patent/SU570326A3/ru active
- 1973-03-06 CH CH327573A patent/CH599118A5/xx not_active IP Right Cessation
- 1973-03-14 YU YU664/73A patent/YU36153B/xx unknown
- 1973-04-27 DD DD170494A patent/DD107672A5/xx unknown
- 1973-05-10 PL PL1973162456A patent/PL92141B1/pl unknown
- 1973-05-10 FR FR7316970A patent/FR2184082B1/fr not_active Expired
- 1973-05-10 BG BG23571A patent/BG21018A3/xx unknown
- 1973-05-11 RO RO7374749A patent/RO69202A/ro unknown
- 1973-05-11 HU HUAE382A patent/HU165871B/hu unknown
- 1973-05-11 BE BE131027A patent/BE799429A/xx not_active IP Right Cessation
- 1973-05-11 JP JP48051785A patent/JPS5757464B2/ja not_active Expired
- 1973-05-11 CS CS733380A patent/CS194673B2/cs unknown
- 1973-05-11 ES ES73414683A patent/ES414683A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| YU36153B (en) | 1982-02-25 |
| AU469300B2 (en) | 1976-02-12 |
| RO69202A (ro) | 1980-05-15 |
| AR196326A1 (es) | 1973-12-18 |
| AU5145373A (en) | 1974-07-25 |
| SU570326A3 (ru) | 1977-08-25 |
| DE2309582B2 (de) | 1981-04-02 |
| CA986510A (en) | 1976-03-30 |
| BG21018A3 (US07655688-20100202-C00109.png) | 1976-01-20 |
| PL92141B1 (US07655688-20100202-C00109.png) | 1977-03-31 |
| BE799429A (fr) | 1973-11-12 |
| ES414683A1 (es) | 1976-05-16 |
| HU165871B (US07655688-20100202-C00109.png) | 1974-12-28 |
| YU66473A (en) | 1981-06-30 |
| JPS4948654A (US07655688-20100202-C00109.png) | 1974-05-11 |
| DE2309582A1 (de) | 1973-11-29 |
| DE2309582C3 (de) | 1982-02-04 |
| CH599118A5 (US07655688-20100202-C00109.png) | 1978-05-12 |
| JPS5757464B2 (US07655688-20100202-C00109.png) | 1982-12-04 |
| DD107672A5 (US07655688-20100202-C00109.png) | 1974-08-12 |
| ZA73517B (en) | 1973-10-31 |
| CS194673B2 (en) | 1979-12-31 |
| PH10297A (en) | 1976-11-10 |
| FR2184082A1 (US07655688-20100202-C00109.png) | 1973-12-21 |
| US4038315A (en) | 1977-07-26 |
| FR2184082B1 (US07655688-20100202-C00109.png) | 1978-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19930211 |