GB1322930A - Benzimidazo 2,1-b quinazolin derivatives as immuno suppressants - Google Patents
Benzimidazo 2,1-b quinazolin derivatives as immuno suppressantsInfo
- Publication number
- GB1322930A GB1322930A GB5562170A GB5562170A GB1322930A GB 1322930 A GB1322930 A GB 1322930A GB 5562170 A GB5562170 A GB 5562170A GB 5562170 A GB5562170 A GB 5562170A GB 1322930 A GB1322930 A GB 1322930A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- carboalkoxy
- compounds
- carbonyl
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229960003444 immunosuppressant agent Drugs 0.000 title abstract 2
- 230000001861 immunosuppressant effect Effects 0.000 title abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 title abstract 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 125000001624 naphthyl group Chemical group 0.000 abstract 3
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- HCTVYGNUCCEYRR-UHFFFAOYSA-N 2,4,7-trichloro-5,6-dimethyl-1h-benzimidazole Chemical compound CC1=C(C)C(Cl)=C2NC(Cl)=NC2=C1Cl HCTVYGNUCCEYRR-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- JKMFSSUTKIFIGP-UHFFFAOYSA-N 2h-benzimidazolo[2,1-b]quinazolin-1-one Chemical class C1=CC=C2N(C=C3C(=O)CC=CC3=N3)C3=NC2=C1 JKMFSSUTKIFIGP-UHFFFAOYSA-N 0.000 abstract 1
- CKUXMYYDAQIJRQ-UHFFFAOYSA-N 5,6-dimethyl-1,3-dihydrobenzimidazole-2-thione Chemical compound C1=C(C)C(C)=CC2=C1NC(=S)N2 CKUXMYYDAQIJRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- -1 trifluoromethylphenyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87957969A | 1969-11-24 | 1969-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1322930A true GB1322930A (en) | 1973-07-11 |
Family
ID=25374430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5562170A Expired GB1322930A (en) | 1969-11-24 | 1970-11-23 | Benzimidazo 2,1-b quinazolin derivatives as immuno suppressants |
Country Status (15)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3963720A (en) * | 1972-10-27 | 1976-06-15 | Sandoz, Inc. | Tetracyclic imidazo [2,1-b] quinazolinone derivatives |
| DE2960689D1 (en) * | 1978-07-28 | 1981-11-19 | Synthelabo | Fluorene and fluoranthene derivatives, process for their preparation and their therapeutic application |
| DE3220438A1 (de) * | 1982-05-29 | 1983-12-01 | Troponwerke GmbH & Co KG, 5000 Köln | Chinazolinonderivate, verfahren zu ihrer herstellung und ihre verwendung inn arzneimitteln |
| AU623910B2 (en) * | 1988-05-16 | 1992-05-28 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Chemotherapeutic composition for aids |
| US6262093B1 (en) | 1995-04-12 | 2001-07-17 | The Proctor & Gamble Company | Methods of treating cancer with benzimidazoles |
| US6479526B1 (en) | 1995-04-12 | 2002-11-12 | The Procter & Gamble Company | Pharmaceutical composition for inhibiting the growth of viruses and cancers |
| ZA962879B (en) * | 1995-04-12 | 1997-03-17 | Procter & Gamble | A pharmaceutical composition for inhibiting the growth of viruses and cancers |
| US6265427B1 (en) | 1995-06-07 | 2001-07-24 | The Proctor & Gamble Company | Pharmaceutical composition for the method of treating leukemia |
| US5900429A (en) * | 1997-01-28 | 1999-05-04 | The Procter & Gamble Company | Method for inhibiting the growth of cancers |
| US6506783B1 (en) | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| US6245789B1 (en) | 1998-05-19 | 2001-06-12 | The Procter & Gamble Company | HIV and viral treatment |
| US6423734B1 (en) | 1999-08-13 | 2002-07-23 | The Procter & Gamble Company | Method of preventing cancer |
| US6380232B1 (en) | 2000-09-26 | 2002-04-30 | The Procter & Gamble Company | Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof |
| US6462062B1 (en) | 2000-09-26 | 2002-10-08 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6407105B1 (en) * | 2000-09-26 | 2002-06-18 | The Procter & Gamble Company | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6608096B1 (en) * | 2000-09-26 | 2003-08-19 | University Of Arizona Foundation | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| US6515074B2 (en) * | 2001-01-22 | 2003-02-04 | Delphi Technologies, Inc. | Thermoplastic polymer alloy compositions and process for manufacture thereof |
| US9185909B2 (en) * | 2007-09-17 | 2015-11-17 | The Trustees Of Columbia University In The City Of New York | Synthesis of resveratrol-based natural products |
| WO2011103442A2 (en) * | 2010-02-18 | 2011-08-25 | The Trustees Of Columbia University In The City Of New York | Synthesis of the potent immunosuppressant agents dalesconol a and b |
| DE102010024542A1 (de) | 2010-06-22 | 2011-12-22 | Merck Patent Gmbh | Materialien für elektronische Vorrichtungen |
| EP3318566B1 (en) * | 2012-09-20 | 2020-06-24 | UDC Ireland Limited | Azadibenzofurans for electronic applications |
| CN112010925B (zh) * | 2019-05-28 | 2021-10-26 | 首都医科大学 | Gde及羟甲基修饰的苯并咪唑喹唑啉，其合成，活性和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3244717A (en) * | 1964-06-18 | 1966-04-05 | Searle & Co | 5-hydroxy-2-methyl-7-phenylimidazo [1, 2-a] pyrimidines |
| US3501473A (en) * | 1967-11-09 | 1970-03-17 | American Home Prod | Disubstituted - 11h - quinazolino - (2,3-b) quinazoline - 11,13 (5h) - diones and the process for their preparation |
-
0
- BE BE759337D patent/BE759337A/xx unknown
-
1969
- 1969-11-24 US US879579A patent/US3669969A/en not_active Expired - Lifetime
-
1970
- 1970-11-02 IE IE1392/70A patent/IE34676B1/xx unknown
- 1970-11-04 IL IL35583A patent/IL35583A/xx unknown
- 1970-11-05 ZA ZA707509A patent/ZA707509B/xx unknown
- 1970-11-17 CA CA098,317A patent/CA974992A/en not_active Expired
- 1970-11-18 ES ES385683A patent/ES385683A1/es not_active Expired
- 1970-11-23 SE SE7015860A patent/SE388617B/xx unknown
- 1970-11-23 GB GB5562170A patent/GB1322930A/en not_active Expired
- 1970-11-23 DE DE19702058185 patent/DE2058185A1/de active Pending
- 1970-11-24 FR FR7042071A patent/FR2073408B1/fr not_active Expired
- 1970-11-24 JP JP45103606A patent/JPS5026560B1/ja active Pending
- 1970-11-24 AT AT1058970A patent/AT310758B/de not_active IP Right Cessation
- 1970-11-24 CH CH1737470A patent/CH560216A5/xx not_active IP Right Cessation
- 1970-11-24 NL NL7017185A patent/NL7017185A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7017185A (enrdf_load_stackoverflow) | 1971-05-26 |
| IL35583A (en) | 1975-02-10 |
| AT310758B (de) | 1973-10-10 |
| ES385683A1 (es) | 1973-10-01 |
| JPS5026560B1 (enrdf_load_stackoverflow) | 1975-09-01 |
| IE34676L (en) | 1971-05-24 |
| FR2073408B1 (enrdf_load_stackoverflow) | 1974-05-24 |
| FR2073408A1 (enrdf_load_stackoverflow) | 1971-10-01 |
| BE759337A (fr) | 1971-05-24 |
| ZA707509B (en) | 1971-08-25 |
| IE34676B1 (en) | 1975-07-09 |
| CA974992A (en) | 1975-09-23 |
| SE388617B (sv) | 1976-10-11 |
| DE2058185A1 (de) | 1971-06-03 |
| IL35583A0 (en) | 1971-01-28 |
| US3669969A (en) | 1972-06-13 |
| CH560216A5 (enrdf_load_stackoverflow) | 1975-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |