IE34676L - BENZIMIDAZO [2, 1-b] QUINAZOLINE DERIVATIVES AS¹IMMUNOSUPPRESSANTS - Google Patents

BENZIMIDAZO [2, 1-b] QUINAZOLINE DERIVATIVES AS¹IMMUNOSUPPRESSANTS

Info

Publication number
IE34676L
IE34676L IE701392A IE139270A IE34676L IE 34676 L IE34676 L IE 34676L IE 701392 A IE701392 A IE 701392A IE 139270 A IE139270 A IE 139270A IE 34676 L IE34676 L IE 34676L
Authority
IE
Ireland
Prior art keywords
benzimidazo
reacting
quinazoline derivatives
ester
anthranilic acid
Prior art date
Application number
IE701392A
Other versions
IE34676B1 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE34676L publication Critical patent/IE34676L/en
Publication of IE34676B1 publication Critical patent/IE34676B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Benzimidazo [2,1-b]quinazolin- 12(6H)ones, immunosuppressives and agents for treatment of auto-immune diseases, are prepared via (1) reacting a 2-chlorobenzimidazole with an anthranilic acid or ester; (2) reacting a 2-aminobenzimidazole with an anthranilic acid or ester in the presence of trifluoroacetic acid or (3) reacting a 2-methylmercaptobenzimidazole with an anthraniloyl halide hydrohalide. [US3669969A]
IE1392/70A 1969-11-24 1970-11-02 Benzimidazo (2,1-b) quinazolin derivatives as immuno suppressants IE34676B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87957969A 1969-11-24 1969-11-24

Publications (2)

Publication Number Publication Date
IE34676L true IE34676L (en) 1971-05-24
IE34676B1 IE34676B1 (en) 1975-07-09

Family

ID=25374430

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1392/70A IE34676B1 (en) 1969-11-24 1970-11-02 Benzimidazo (2,1-b) quinazolin derivatives as immuno suppressants

Country Status (15)

Country Link
US (1) US3669969A (en)
JP (1) JPS5026560B1 (en)
AT (1) AT310758B (en)
BE (1) BE759337A (en)
CA (1) CA974992A (en)
CH (1) CH560216A5 (en)
DE (1) DE2058185A1 (en)
ES (1) ES385683A1 (en)
FR (1) FR2073408B1 (en)
GB (1) GB1322930A (en)
IE (1) IE34676B1 (en)
IL (1) IL35583A (en)
NL (1) NL7017185A (en)
SE (1) SE388617B (en)
ZA (1) ZA707509B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963720A (en) * 1972-10-27 1976-06-15 Sandoz, Inc. Tetracyclic imidazo [2,1-b] quinazolinone derivatives
DE2960689D1 (en) * 1978-07-28 1981-11-19 Synthelabo Fluorene and fluoranthene derivatives, process for their preparation and their therapeutic application
DE3220438A1 (en) * 1982-05-29 1983-12-01 Troponwerke GmbH & Co KG, 5000 Köln CHINAZOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
EP0416011A4 (en) * 1988-05-16 1991-05-22 Us Commerce Chemotherapeutic composition for aids
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6262093B1 (en) 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
ZA962879B (en) * 1995-04-12 1997-03-17 Procter & Gamble A pharmaceutical composition for inhibiting the growth of viruses and cancers
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
US5900429A (en) 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
US6506783B1 (en) * 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6608096B1 (en) 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6407105B1 (en) * 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6515074B2 (en) * 2001-01-22 2003-02-04 Delphi Technologies, Inc. Thermoplastic polymer alloy compositions and process for manufacture thereof
WO2009038731A2 (en) * 2007-09-17 2009-03-26 The Trustees Of Columbia University In The City Of New York Synthesis of resveratrol-based natural products
WO2011103442A2 (en) * 2010-02-18 2011-08-25 The Trustees Of Columbia University In The City Of New York Synthesis of the potent immunosuppressant agents dalesconol a and b
DE102010024542A1 (en) * 2010-06-22 2011-12-22 Merck Patent Gmbh Materials for electronic devices
JP6333262B2 (en) * 2012-09-20 2018-05-30 ユー・ディー・シー アイルランド リミテッド Azadibenzofuran for electronic applications
CN112010925B (en) * 2019-05-28 2021-10-26 首都医科大学 GDE and hydroxymethyl modified benzimidazole quinazoline, synthesis, activity and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244717A (en) * 1964-06-18 1966-04-05 Searle & Co 5-hydroxy-2-methyl-7-phenylimidazo [1, 2-a] pyrimidines
US3501473A (en) * 1967-11-09 1970-03-17 American Home Prod Disubstituted - 11h - quinazolino - (2,3-b) quinazoline - 11,13 (5h) - diones and the process for their preparation

Also Published As

Publication number Publication date
AT310758B (en) 1973-10-10
JPS5026560B1 (en) 1975-09-01
DE2058185A1 (en) 1971-06-03
ES385683A1 (en) 1973-10-01
IE34676B1 (en) 1975-07-09
IL35583A0 (en) 1971-01-28
FR2073408B1 (en) 1974-05-24
ZA707509B (en) 1971-08-25
NL7017185A (en) 1971-05-26
CA974992A (en) 1975-09-23
GB1322930A (en) 1973-07-11
SE388617B (en) 1976-10-11
BE759337A (en) 1971-05-24
IL35583A (en) 1975-02-10
FR2073408A1 (en) 1971-10-01
CH560216A5 (en) 1975-03-27
US3669969A (en) 1972-06-13

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