ES385683A1 - BENZIMIDAZO {8 2,1-b{9 {0 QUINALOZIN-12-(6H)ONES - Google Patents

BENZIMIDAZO {8 2,1-b{9 {0 QUINALOZIN-12-(6H)ONES

Info

Publication number
ES385683A1
ES385683A1 ES385683A ES385683A ES385683A1 ES 385683 A1 ES385683 A1 ES 385683A1 ES 385683 A ES385683 A ES 385683A ES 385683 A ES385683 A ES 385683A ES 385683 A1 ES385683 A1 ES 385683A1
Authority
ES
Spain
Prior art keywords
benzimidazo
ones
reacting
quinalozin
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES385683A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES385683A1 publication Critical patent/ES385683A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Benzimidazo [2,1-b]quinazolin- 12(6H)ones, immunosuppressives and agents for treatment of auto-immune diseases, are prepared via (1) reacting a 2-chlorobenzimidazole with an anthranilic acid or ester (2) reacting a 2-aminobenzimidazole with an anthranilic acid or ester in the presence of trifluoroacetic acid or (3) reacting a 2-methylmercaptobenzimidazole with an anthraniloyl halide hydrohalide.
ES385683A 1969-11-24 1970-11-18 BENZIMIDAZO {8 2,1-b{9 {0 QUINALOZIN-12-(6H)ONES Expired ES385683A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87957969A 1969-11-24 1969-11-24

Publications (1)

Publication Number Publication Date
ES385683A1 true ES385683A1 (en) 1973-10-01

Family

ID=25374430

Family Applications (1)

Application Number Title Priority Date Filing Date
ES385683A Expired ES385683A1 (en) 1969-11-24 1970-11-18 BENZIMIDAZO {8 2,1-b{9 {0 QUINALOZIN-12-(6H)ONES

Country Status (15)

Country Link
US (1) US3669969A (en)
JP (1) JPS5026560B1 (en)
AT (1) AT310758B (en)
BE (1) BE759337A (en)
CA (1) CA974992A (en)
CH (1) CH560216A5 (en)
DE (1) DE2058185A1 (en)
ES (1) ES385683A1 (en)
FR (1) FR2073408B1 (en)
GB (1) GB1322930A (en)
IE (1) IE34676B1 (en)
IL (1) IL35583A (en)
NL (1) NL7017185A (en)
SE (1) SE388617B (en)
ZA (1) ZA707509B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963720A (en) * 1972-10-27 1976-06-15 Sandoz, Inc. Tetracyclic imidazo [2,1-b] quinazolinone derivatives
ATE165T1 (en) * 1978-07-28 1981-09-15 Synthelabo FLUORENE AND FLUORANTHENE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.
DE3220438A1 (en) * 1982-05-29 1983-12-01 Troponwerke GmbH & Co KG, 5000 Köln CHINAZOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS
AU623910B2 (en) * 1988-05-16 1992-05-28 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Chemotherapeutic composition for aids
US6262093B1 (en) 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
ZA962879B (en) * 1995-04-12 1997-03-17 Procter & Gamble A pharmaceutical composition for inhibiting the growth of viruses and cancers
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
US5900429A (en) 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
US6506783B1 (en) 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6407105B1 (en) * 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6608096B1 (en) * 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6462062B1 (en) * 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6515074B2 (en) * 2001-01-22 2003-02-04 Delphi Technologies, Inc. Thermoplastic polymer alloy compositions and process for manufacture thereof
WO2009038731A2 (en) * 2007-09-17 2009-03-26 The Trustees Of Columbia University In The City Of New York Synthesis of resveratrol-based natural products
WO2011103442A2 (en) * 2010-02-18 2011-08-25 The Trustees Of Columbia University In The City Of New York Synthesis of the potent immunosuppressant agents dalesconol a and b
DE102010024542A1 (en) * 2010-06-22 2011-12-22 Merck Patent Gmbh Materials for electronic devices
EP2897959B1 (en) * 2012-09-20 2017-12-20 UDC Ireland Limited Azadibenzofurans for electronic applications
CN112010925B (en) * 2019-05-28 2021-10-26 首都医科大学 GDE and hydroxymethyl modified benzimidazole quinazoline, synthesis, activity and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244717A (en) * 1964-06-18 1966-04-05 Searle & Co 5-hydroxy-2-methyl-7-phenylimidazo [1, 2-a] pyrimidines
US3501473A (en) * 1967-11-09 1970-03-17 American Home Prod Disubstituted - 11h - quinazolino - (2,3-b) quinazoline - 11,13 (5h) - diones and the process for their preparation

Also Published As

Publication number Publication date
IE34676B1 (en) 1975-07-09
CA974992A (en) 1975-09-23
FR2073408B1 (en) 1974-05-24
IE34676L (en) 1971-05-24
FR2073408A1 (en) 1971-10-01
AT310758B (en) 1973-10-10
BE759337A (en) 1971-05-24
NL7017185A (en) 1971-05-26
US3669969A (en) 1972-06-13
DE2058185A1 (en) 1971-06-03
GB1322930A (en) 1973-07-11
JPS5026560B1 (en) 1975-09-01
SE388617B (en) 1976-10-11
ZA707509B (en) 1971-08-25
IL35583A0 (en) 1971-01-28
CH560216A5 (en) 1975-03-27
IL35583A (en) 1975-02-10

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