GB1530675A - Guanidine derivatives - Google Patents

Guanidine derivatives

Info

Publication number
GB1530675A
GB1530675A GB23331/76A GB2333176A GB1530675A GB 1530675 A GB1530675 A GB 1530675A GB 23331/76 A GB23331/76 A GB 23331/76A GB 2333176 A GB2333176 A GB 2333176A GB 1530675 A GB1530675 A GB 1530675A
Authority
GB
United Kingdom
Prior art keywords
represent
lower alkyl
trifluoromethyl
halogen
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23331/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB23331/76A priority Critical patent/GB1530675A/en
Priority to ZA00772937A priority patent/ZA772937B/en
Priority to IE1011/77A priority patent/IE45198B1/en
Priority to AU25356/77A priority patent/AU509883B2/en
Priority to CA279,260A priority patent/CA1070691A/en
Priority to US05/801,973 priority patent/US4140793A/en
Priority to CY1130A priority patent/CY1130A/en
Priority to DE19772724989 priority patent/DE2724989A1/en
Priority to FR7717042A priority patent/FR2353530A1/en
Priority to NL7706173A priority patent/NL7706173A/en
Priority to SE7706520A priority patent/SE424861B/en
Priority to DK248177A priority patent/DK248177A/en
Priority to JP6497377A priority patent/JPS52151161A/en
Priority to CH688677A priority patent/CH641159A5/en
Priority to BE178198A priority patent/BE855392A/en
Publication of GB1530675A publication Critical patent/GB1530675A/en
Priority to DO1981004022A priority patent/DOP1981004022A/en
Priority to KE3170A priority patent/KE3170A/en
Priority to HK579/81A priority patent/HK57981A/en
Priority to MY180/82A priority patent/MY8200180A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

1530675 Guanidine derivatives JOHN WYETH & BRO Ltd 1 June 1977 [5 June 1977 26 Jan 1977] 23331/76 and 03056/77 Heading C2C Novel compounds of Formula I or a salt thereof wherein the nitrogen heterocyclic ring may be of formula (a), (b) or (c) wherein R<SP>1</SP> and R<SP>2</SP> which may be the same or different each represent hydrogen, lower alkyl, trifluoromethyl or halogen and R<SP>11</SP> and R<SP>12</SP> which may be the same or different each represent hydrogen, lower alkyl trifluoromethyl or halogen with the proviso that when one or both R<SP>11</SP> or R<SP>12</SP> groups represent halogen then R<SP>1</SP> and R<SP>2</SP> each represent lower alkyl, trifluoromethyl or halogen, R‹ and R<SP>10</SP> which may be the same or different each represents hydrogen, lower alkyl or trifluoromethyl and R<SP>13</SP> and R<SP>14</SP> which may be the same or different each represents hydrogen, lower alkyl, trifluoromethyl or halogen with the proviso that when one or both R<SP>13</SP> and R<SP>11</SP> groups represent halogen then R<SP>9</SP> and R<SP>10</SP> each represent lower alkyl or trifluoromethyl and R<SP>7</SP> and R<SP>8</SP> are the same or different and each represent hydrogen or lower alkyl and R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> are the same or different and each represent hydrogen or lower alkyl or R<SP>4</SP> and R<SP>6</SP> are each hydrogen and R<SP>3</SP> and R<SP>5</SP> together represent dimethylene or trimethylene such that group of formula(e) represent:- and lower denotes groups containing up to 6 carbon atoms are prepared by standard methods, e.g. by formation of the acylimino bond link in standard fashion from the two halves. Intermediates and starting materials are also prepared. Pharmaceutical compositions in standard form and having hypertensive hyperglycemic and antiulcer activity comprise an above novel compound and a carrier or diluent.
GB23331/76A 1976-06-05 1976-06-05 Guanidine derivatives Expired GB1530675A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB23331/76A GB1530675A (en) 1976-06-05 1976-06-05 Guanidine derivatives
ZA00772937A ZA772937B (en) 1976-06-05 1977-05-17 Guanidine derivatives
IE1011/77A IE45198B1 (en) 1976-06-05 1977-05-17 Guanidine derivatives
AU25356/77A AU509883B2 (en) 1976-06-05 1977-05-20 Guanidine derivatives
CA279,260A CA1070691A (en) 1976-06-05 1977-05-24 Guanidine derivatives
US05/801,973 US4140793A (en) 1976-06-05 1977-05-31 Guanidine derivatives
CY1130A CY1130A (en) 1976-06-05 1977-06-01 Guanidine derivatives
DE19772724989 DE2724989A1 (en) 1976-06-05 1977-06-02 GUANIDE DERIVATIVES, METHODS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS
NL7706173A NL7706173A (en) 1976-06-05 1977-06-03 PROCESS OF PREPARING NEW GUANIDINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS.
FR7717042A FR2353530A1 (en) 1976-06-05 1977-06-03 NEW GUANIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
SE7706520A SE424861B (en) 1976-06-05 1977-06-03 PROCEDURE FOR PREPARING NEW THERAPEUTICALLY ACTIVE DERIVATIVES OF GUANIDINE CONTAINING A PYRROL, PYRROLINE OR PYRROLIDINE REST
DK248177A DK248177A (en) 1976-06-05 1977-06-03 GUANIDINE DERIVATIVES AND THEIR MANUFACTURE AND USE
JP6497377A JPS52151161A (en) 1976-06-05 1977-06-03 Guanidine derivative and its preparation
CH688677A CH641159A5 (en) 1976-06-05 1977-06-03 METHOD FOR PRODUCING NEW GUANIDE DERIVATIVES.
BE178198A BE855392A (en) 1976-06-05 1977-06-03 NEW GUANIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
DO1981004022A DOP1981004022A (en) 1976-06-05 1981-07-30 NEW DERIVATIVES OF GUANIDINE PREPARATION FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
KE3170A KE3170A (en) 1976-06-05 1981-11-10 Guanidine derivatives
HK579/81A HK57981A (en) 1976-06-05 1981-11-26 Guanidine derivatives
MY180/82A MY8200180A (en) 1976-06-05 1982-12-30 Guanidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB23331/76A GB1530675A (en) 1976-06-05 1976-06-05 Guanidine derivatives

Publications (1)

Publication Number Publication Date
GB1530675A true GB1530675A (en) 1978-11-01

Family

ID=10193890

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23331/76A Expired GB1530675A (en) 1976-06-05 1976-06-05 Guanidine derivatives

Country Status (4)

Country Link
BE (1) BE855392A (en)
DO (1) DOP1981004022A (en)
GB (1) GB1530675A (en)
ZA (1) ZA772937B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040947A1 (en) * 1980-05-27 1981-12-02 JOHN WYETH &amp; BROTHER LIMITED Use of guanidines for manufacturing antidiarrhoeal medicaments and antidiarrhoeal compositions containing these guanidines
GB2181347A (en) * 1985-10-10 1987-04-23 Wyeth John & Brother Ltd Antidiarrhoeal agents containing guanidine derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040947A1 (en) * 1980-05-27 1981-12-02 JOHN WYETH &amp; BROTHER LIMITED Use of guanidines for manufacturing antidiarrhoeal medicaments and antidiarrhoeal compositions containing these guanidines
US4443467A (en) * 1980-05-27 1984-04-17 John Wyeth & Brother, Limited Antidiarrhoeal agents
GB2181347A (en) * 1985-10-10 1987-04-23 Wyeth John & Brother Ltd Antidiarrhoeal agents containing guanidine derivatives
GB2181347B (en) * 1985-10-10 1989-09-27 Wyeth John & Brother Ltd Antidiarrhoeal agents containing guanidine derivatives

Also Published As

Publication number Publication date
ZA772937B (en) 1978-12-27
DOP1981004022A (en) 1987-12-01
BE855392A (en) 1977-12-05

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee