GB1154682A - Lysergic Acid Derivatives - Google Patents
Lysergic Acid DerivativesInfo
- Publication number
- GB1154682A GB1154682A GB181367A GB181367A GB1154682A GB 1154682 A GB1154682 A GB 1154682A GB 181367 A GB181367 A GB 181367A GB 181367 A GB181367 A GB 181367A GB 1154682 A GB1154682 A GB 1154682A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- lysergic
- lysergic acid
- acid derivatives
- carbons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,154,682. Lysergic acid derivatives. SANDOZ Ltd. 12 Jan., 1967 [8 Feb., 1966; 9 Dec., 1966], No. 1813/67. Heading C2C. Novel lysergic acid derivatives (and acid addition salts thereof) of the general formula wherein R<SP>1</SP> is H or Me, R<SP>2</SP> is aralkyl of from 7 to 9 carbons on an aryl radical which may be substituted by one or more Me, alkoxy, having 1 to 4 carbons, chlorine or bromine substituents and x#y is are prepared by the interaction of a functional acid derivative of the appropriate d-lysergic acid or 9,10-dihydro-d-lysergic acid (e.g. acid chloride hydrochloride, acid azide or a mixed anhydride with sulphuric acid) and the appropriate piperazine compound. Compounds of the invention wherein R<SP>1</SP> is H may be methylated to the corresponding N-methyl derivative and those wherein x#y is may be hydrogenated in the presence of a catalyst to afford a 9,10-dihydro-compound. Pharmaceutical compositions exhibiting sedative-neuroleptic properties and also having a sympathomimetio and serotonin antagonistic effect contain as the active ingredient the above novel compounds and may be provided in the form of tablets, dragÚes, syrups, injection solutions and suppositories.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH175666A CH475252A (en) | 1966-02-08 | 1966-02-08 | Process for the production of new lysergic acid derivatives |
| CH1753066A CH493521A (en) | 1966-02-08 | 1966-12-09 | (A) Compds. (I):- where R1 = H or Me; R2 = 7-9 C aralkyl or aryl (opt. substd. by one or more methyl or 1-4 C alkoxy groups, Br or Cl); X Y = CH |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1154682A true GB1154682A (en) | 1969-06-11 |
Family
ID=25688570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB181367A Expired GB1154682A (en) | 1966-02-08 | 1967-01-12 | Lysergic Acid Derivatives |
Country Status (8)
| Country | Link |
|---|---|
| CH (2) | CH475252A (en) |
| DE (1) | DE1695682A1 (en) |
| DK (1) | DK125175B (en) |
| ES (1) | ES336531A1 (en) |
| FI (1) | FI47189C (en) |
| FR (2) | FR1510553A (en) |
| GB (1) | GB1154682A (en) |
| SE (1) | SE324785B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE564825A (en) * | 1957-02-15 | |||
| IL41409A (en) * | 1972-02-04 | 1977-04-29 | Richter Gedeon Vegyeszet | Lysergic acid amides and process for their preparation |
| HU169073B (en) * | 1974-05-28 | 1976-09-28 | ||
| GB9711043D0 (en) * | 1997-05-29 | 1997-07-23 | Ciba Geigy Ag | Organic compounds |
-
1966
- 1966-02-08 CH CH175666A patent/CH475252A/en not_active IP Right Cessation
- 1966-12-09 CH CH1753066A patent/CH493521A/en not_active IP Right Cessation
-
1967
- 1967-01-12 GB GB181367A patent/GB1154682A/en not_active Expired
- 1967-02-04 DE DE19671695682 patent/DE1695682A1/en active Pending
- 1967-02-06 FI FI33867A patent/FI47189C/en active
- 1967-02-07 ES ES336531A patent/ES336531A1/en not_active Expired
- 1967-02-07 FR FR93979A patent/FR1510553A/en not_active Expired
- 1967-02-07 DK DK66267A patent/DK125175B/en unknown
- 1967-02-07 SE SE1702/67A patent/SE324785B/xx unknown
- 1967-05-03 FR FR105145A patent/FR6554M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI47189B (en) | 1973-07-02 |
| FR6554M (en) | 1968-12-23 |
| DK125175B (en) | 1973-01-08 |
| FI47189C (en) | 1973-10-10 |
| DE1695682A1 (en) | 1971-04-08 |
| ES336531A1 (en) | 1968-04-01 |
| CH475252A (en) | 1969-07-15 |
| CH493521A (en) | 1970-07-15 |
| SE324785B (en) | 1970-06-15 |
| FR1510553A (en) | 1968-01-19 |
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