GB1292785A - Derivatives of dexa- and beta-methasone, their production and use - Google Patents
Derivatives of dexa- and beta-methasone, their production and useInfo
- Publication number
- GB1292785A GB1292785A GB22811/71A GB2281171A GB1292785A GB 1292785 A GB1292785 A GB 1292785A GB 22811/71 A GB22811/71 A GB 22811/71A GB 2281171 A GB2281171 A GB 2281171A GB 1292785 A GB1292785 A GB 1292785A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dexamethasone
- betamethasone
- beta
- prepared
- methasone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical class C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 title abstract 4
- 229960002537 betamethasone Drugs 0.000 title abstract 3
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 title abstract 3
- 229960003957 dexamethasone Drugs 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- 239000012359 Methanesulfonyl chloride Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 1
- 235000021342 arachidonic acid Nutrition 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 235000020778 linoleic acid Nutrition 0.000 abstract 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
- 235000021313 oleic acid Nutrition 0.000 abstract 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT31143/70A IT1043956B (it) | 1970-10-17 | 1970-10-17 | 21 esteri di acidi grassi insaturi del desa e beta metazone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1292785A true GB1292785A (en) | 1972-10-11 |
Family
ID=11233166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22811/71A Expired GB1292785A (en) | 1970-10-17 | 1971-04-19 | Derivatives of dexa- and beta-methasone, their production and use |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5125023B1 (enExample) |
| BE (1) | BE764130A (enExample) |
| DE (1) | DE2113163C3 (enExample) |
| FR (1) | FR2112302B1 (enExample) |
| GB (1) | GB1292785A (enExample) |
| IT (1) | IT1043956B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6762175B2 (en) | 1997-01-24 | 2004-07-13 | Norsk Hydro Asa | Fatty acid derivatives |
| US7390796B2 (en) | 2002-10-08 | 2008-06-24 | Sepracor Inc. | Fatty acid modified forms of glucocorticoids |
| WO2008115069A3 (en) * | 2007-03-20 | 2008-11-13 | Clavis Pharma As | Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5879533U (ja) * | 1981-11-26 | 1983-05-30 | 大熊 英彦 | ポケツト付封筒 |
| JPS62188438U (enExample) * | 1986-05-19 | 1987-12-01 |
-
1970
- 1970-10-17 IT IT31143/70A patent/IT1043956B/it active
-
1971
- 1971-03-11 BE BE764130A patent/BE764130A/xx unknown
- 1971-03-17 FR FR7109385A patent/FR2112302B1/fr not_active Expired
- 1971-03-18 DE DE2113163A patent/DE2113163C3/de not_active Expired
- 1971-04-19 GB GB22811/71A patent/GB1292785A/en not_active Expired
- 1971-10-12 JP JP46079928A patent/JPS5125023B1/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6762175B2 (en) | 1997-01-24 | 2004-07-13 | Norsk Hydro Asa | Fatty acid derivatives |
| US7390796B2 (en) | 2002-10-08 | 2008-06-24 | Sepracor Inc. | Fatty acid modified forms of glucocorticoids |
| WO2008115069A3 (en) * | 2007-03-20 | 2008-11-13 | Clavis Pharma As | Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents |
| AU2008227246B2 (en) * | 2007-03-20 | 2012-06-14 | Clavis Pharma Asa | Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1043956B (it) | 1980-02-29 |
| DE2113163B2 (de) | 1974-02-07 |
| DE2113163C3 (de) | 1974-09-12 |
| BE764130A (fr) | 1971-08-02 |
| DE2113163A1 (de) | 1972-04-20 |
| JPS5125023B1 (enExample) | 1976-07-28 |
| FR2112302A1 (enExample) | 1972-06-16 |
| FR2112302B1 (enExample) | 1974-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |