GB1292269A - Pregnane derivatives and process for preparation thereof - Google Patents

Pregnane derivatives and process for preparation thereof

Info

Publication number
GB1292269A
GB1292269A GB986870A GB986870A GB1292269A GB 1292269 A GB1292269 A GB 1292269A GB 986870 A GB986870 A GB 986870A GB 986870 A GB986870 A GB 986870A GB 1292269 A GB1292269 A GB 1292269A
Authority
GB
United Kingdom
Prior art keywords
group
triamcinolone
alkanoyl radical
preparation
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB986870A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR6906348A external-priority patent/FR2035766A1/en
Priority claimed from FR6938912A external-priority patent/FR2068427A1/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB1292269A publication Critical patent/GB1292269A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1292269 A triamcinolone ketal and esters thereof ROUSSEL-UCLAF SA 2 March 1970 9868/70 Heading C2U The invention comprises 9-fluoro-11#,21- 1 - dihydroxy - 16α,17 - (2 - propenylidenedioxy)- pregna - 1,4 - diene - 3,20 - dione and its 21- C 2-6 alkanoates) wherein the alkanoyl radical is optionally substituted by a CO 2 H, CO 2 NH 4 , or CO 2 M group (M being an alkali metal), said group being separated from the carbonyl group of the alkanoyl radical by at least two carbon atoms. These compounds are prepared by reacting triamcinolone with acrolein in the presence of an acid catalyst, optionally followed by 21- alkanoylation and optional salification. The inventive compounds are stated to possess thymolytic, glycogenic and antiinflammatory activities and may be made up with carriers into pharmaceutical compositions for oral, parenteral, rectal and topical administration.
GB986870A 1969-03-07 1970-03-02 Pregnane derivatives and process for preparation thereof Expired GB1292269A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR6906348A FR2035766A1 (en) 1969-03-07 1969-03-07 Preparation of prenane derivs
FR6938912A FR2068427A1 (en) 1969-11-13 1969-11-13 Preparation of prenane derivs

Publications (1)

Publication Number Publication Date
GB1292269A true GB1292269A (en) 1972-10-11

Family

ID=26214890

Family Applications (1)

Application Number Title Priority Date Filing Date
GB986870A Expired GB1292269A (en) 1969-03-07 1970-03-02 Pregnane derivatives and process for preparation thereof

Country Status (9)

Country Link
JP (1) JPS4843910B1 (en)
BE (1) BE746965A (en)
DK (1) DK122812B (en)
ES (1) ES376421A1 (en)
FI (1) FI47573C (en)
GB (1) GB1292269A (en)
NL (1) NL7001308A (en)
NO (1) NO134746C (en)
SE (1) SE360652B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019136487A3 (en) * 2018-01-08 2019-09-12 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019136487A3 (en) * 2018-01-08 2019-09-12 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof

Also Published As

Publication number Publication date
BE746965A (en) 1970-09-07
DE2006635A1 (en) 1970-09-24
NO134746C (en) 1976-12-08
JPS4843910B1 (en) 1973-12-21
SE360652B (en) 1973-10-01
FI47573C (en) 1974-01-10
FI47573B (en) 1973-10-01
NL7001308A (en) 1970-09-09
ES376421A1 (en) 1972-04-16
NO134746B (en) 1976-08-30
DK122812B (en) 1972-04-17

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee