FR2068427A1 - Preparation of prenane derivs - Google Patents

Preparation of prenane derivs

Info

Publication number
FR2068427A1
FR2068427A1 FR6938912A FR6938912A FR2068427A1 FR 2068427 A1 FR2068427 A1 FR 2068427A1 FR 6938912 A FR6938912 A FR 6938912A FR 6938912 A FR6938912 A FR 6938912A FR 2068427 A1 FR2068427 A1 FR 2068427A1
Authority
FR
France
Prior art keywords
derivs
carboxyl
prenane
preparation
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6938912A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR6938912A priority Critical patent/FR2068427A1/en
Priority to NL7001308A priority patent/NL7001308A/xx
Priority to ES376421A priority patent/ES376421A1/en
Priority to DE19702006635 priority patent/DE2006635C/en
Priority to GB986870A priority patent/GB1292269A/en
Priority to FI58970A priority patent/FI47573C/en
Priority to SE293170A priority patent/SE360652B/xx
Priority to BE746965D priority patent/BE746965A/en
Priority to NO80170A priority patent/NO134746C/no
Priority to JP1967870A priority patent/JPS4843910B1/ja
Priority to DK114170A priority patent/DK122812B/en
Publication of FR2068427A1 publication Critical patent/FR2068427A1/en
Priority to US00251513A priority patent/US3798216A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Pregnane derivs. of gen. formula (I): (where R is H, acyl radical of satd., C2-6, aliphatic linear or branched, carboxylic acid, opt. substd. by a free (COOH) or esterified (COOA where A is alkali metal or ammonium) carboxyl gp. The carboxyl gp. is separated from the acyl CO gp. by at least 2C-atoms). Pref. cpd. prepd. by acetylisation of acrolein and fluoro-9-tetra-hydroxy-11 beta, 16 alpha, 17, 21-pregnadiene-1,4-dione-3,20 in presence of acid catalyst and esterifying with acid anhydride. Cpds. used as antiinflammatory, thymolytic and glycogenic agents.
FR6938912A 1969-03-07 1969-11-13 Preparation of prenane derivs Withdrawn FR2068427A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR6938912A FR2068427A1 (en) 1969-11-13 1969-11-13 Preparation of prenane derivs
NL7001308A NL7001308A (en) 1969-03-07 1970-01-29
ES376421A ES376421A1 (en) 1969-03-07 1970-02-10 Pregnane derivatives and process for preparation thereof
DE19702006635 DE2006635C (en) 1969-03-07 1970-02-13 löalpha, 17alpha (propen 2 yhden dioxy) 9 fluorine 1 lbeta, 21 dihydroxy delta high 1.4 pregnadienes or their 21 esters, process for their production and pharmaceutical agents containing them as the sole active ingredient
GB986870A GB1292269A (en) 1969-03-07 1970-03-02 Pregnane derivatives and process for preparation thereof
FI58970A FI47573C (en) 1969-03-07 1970-03-04 Process for the preparation of -fluoro-11,21-dihydroxy-16,17 (2-propenylidenedioxy) -p Regna-1,4-diene-3,20-dione and its 21-esters.
SE293170A SE360652B (en) 1969-03-07 1970-03-05
BE746965D BE746965A (en) 1969-03-07 1970-03-06 PREGNANE DERIVATIVES, METHOD OF PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS
NO80170A NO134746C (en) 1969-03-07 1970-03-06
JP1967870A JPS4843910B1 (en) 1969-03-07 1970-03-07
DK114170A DK122812B (en) 1969-03-07 1970-03-09 Analogous process for the preparation of 9α-fluoro-11β, 21-dihydroxy-16α-17α- (2-propenylidenedioxy) -pregna-1,4-diene-3,20-dione or 21-esters thereof.
US00251513A US3798216A (en) 1969-03-07 1972-05-08 9-fluoro-11beta,21-dihydroxy-16alpha,17-(2-propenylidenedioxy)-pregna-1,4-diene-3,20-dione and derivatives thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6938912A FR2068427A1 (en) 1969-11-13 1969-11-13 Preparation of prenane derivs

Publications (1)

Publication Number Publication Date
FR2068427A1 true FR2068427A1 (en) 1971-08-27

Family

ID=9042961

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6938912A Withdrawn FR2068427A1 (en) 1969-03-07 1969-11-13 Preparation of prenane derivs

Country Status (1)

Country Link
FR (1) FR2068427A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids

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Legal Events

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ST Notification of lapse