FR2018309A1 - Anti-androgenic 11-beta, 17 alpha-dihydroxy-a-nor- - progesterone and its esters - Google Patents
Anti-androgenic 11-beta, 17 alpha-dihydroxy-a-nor- - progesterone and its estersInfo
- Publication number
- FR2018309A1 FR2018309A1 FR6931314A FR6931314A FR2018309A1 FR 2018309 A1 FR2018309 A1 FR 2018309A1 FR 6931314 A FR6931314 A FR 6931314A FR 6931314 A FR6931314 A FR 6931314A FR 2018309 A1 FR2018309 A1 FR 2018309A1
- Authority
- FR
- France
- Prior art keywords
- progesterone
- alpha
- androgenic
- dihydroxy
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Anti-androgenic 11-beta, 17 alpha-dihydroxy-A-nor-progesterone and its esters. G3A. Are new cpds. of formula (I) (where R and R' are H or acyl, pref. derived from 12 C hydrocarbon carboxylic acids). Prepared by subjecting 17 alpha-hydroxy-A-nor-progesterone (II) to the action of a microorganism of the genus Curvularia (pref. C. Lumata) and opt. acylating the resulting (I; R=R'=H) with a carboxylic acid anhydride (pref. Ac20) in the presence of a catalytic amount of HCl04 and opt. converting the resulting (I; R=R'=acyl) into (I; R=acyl, R'=H) by treating with aqs. soln. of a weak base (e.g. Na2CO3, K2CO3).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86072168A | 1968-09-18 | 1968-09-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2018309A1 true FR2018309A1 (en) | 1970-05-29 |
FR2018309B1 FR2018309B1 (en) | 1973-03-16 |
Family
ID=25333872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR6931314A Granted FR2018309A1 (en) | 1968-09-18 | 1969-09-15 | Anti-androgenic 11-beta, 17 alpha-dihydroxy-a-nor- - progesterone and its esters |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2018309A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1164173A (en) * | 1953-04-21 | 1958-10-07 | Pfizer & Co C | Improvements to the processes for preparing steroid compounds |
US3330861A (en) * | 1965-06-18 | 1967-07-11 | Squibb & Sons Inc | 11, 17-oxygenated a-norprogesterones |
-
1969
- 1969-09-15 FR FR6931314A patent/FR2018309A1/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1164173A (en) * | 1953-04-21 | 1958-10-07 | Pfizer & Co C | Improvements to the processes for preparing steroid compounds |
US3330861A (en) * | 1965-06-18 | 1967-07-11 | Squibb & Sons Inc | 11, 17-oxygenated a-norprogesterones |
Also Published As
Publication number | Publication date |
---|---|
FR2018309B1 (en) | 1973-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |