FR2018309A1 - Anti-androgenic 11-beta, 17 alpha-dihydroxy-a-nor- - progesterone and its esters - Google Patents

Anti-androgenic 11-beta, 17 alpha-dihydroxy-a-nor- - progesterone and its esters

Info

Publication number
FR2018309A1
FR2018309A1 FR6931314A FR6931314A FR2018309A1 FR 2018309 A1 FR2018309 A1 FR 2018309A1 FR 6931314 A FR6931314 A FR 6931314A FR 6931314 A FR6931314 A FR 6931314A FR 2018309 A1 FR2018309 A1 FR 2018309A1
Authority
FR
France
Prior art keywords
progesterone
alpha
androgenic
dihydroxy
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR6931314A
Other languages
French (fr)
Other versions
FR2018309B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2018309A1 publication Critical patent/FR2018309A1/en
Application granted granted Critical
Publication of FR2018309B1 publication Critical patent/FR2018309B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Anti-androgenic 11-beta, 17 alpha-dihydroxy-A-nor-progesterone and its esters. G3A. Are new cpds. of formula (I) (where R and R' are H or acyl, pref. derived from 12 C hydrocarbon carboxylic acids). Prepared by subjecting 17 alpha-hydroxy-A-nor-progesterone (II) to the action of a microorganism of the genus Curvularia (pref. C. Lumata) and opt. acylating the resulting (I; R=R'=H) with a carboxylic acid anhydride (pref. Ac20) in the presence of a catalytic amount of HCl04 and opt. converting the resulting (I; R=R'=acyl) into (I; R=acyl, R'=H) by treating with aqs. soln. of a weak base (e.g. Na2CO3, K2CO3).
FR6931314A 1968-09-18 1969-09-15 Anti-androgenic 11-beta, 17 alpha-dihydroxy-a-nor- - progesterone and its esters Granted FR2018309A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86072168A 1968-09-18 1968-09-18

Publications (2)

Publication Number Publication Date
FR2018309A1 true FR2018309A1 (en) 1970-05-29
FR2018309B1 FR2018309B1 (en) 1973-03-16

Family

ID=25333872

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6931314A Granted FR2018309A1 (en) 1968-09-18 1969-09-15 Anti-androgenic 11-beta, 17 alpha-dihydroxy-a-nor- - progesterone and its esters

Country Status (1)

Country Link
FR (1) FR2018309A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1164173A (en) * 1953-04-21 1958-10-07 Pfizer & Co C Improvements to the processes for preparing steroid compounds
US3330861A (en) * 1965-06-18 1967-07-11 Squibb & Sons Inc 11, 17-oxygenated a-norprogesterones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1164173A (en) * 1953-04-21 1958-10-07 Pfizer & Co C Improvements to the processes for preparing steroid compounds
US3330861A (en) * 1965-06-18 1967-07-11 Squibb & Sons Inc 11, 17-oxygenated a-norprogesterones

Also Published As

Publication number Publication date
FR2018309B1 (en) 1973-03-16

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