ES376421A1 - Pregnane derivatives and process for preparation thereof - Google Patents

Pregnane derivatives and process for preparation thereof

Info

Publication number
ES376421A1
ES376421A1 ES376421A ES376421A ES376421A1 ES 376421 A1 ES376421 A1 ES 376421A1 ES 376421 A ES376421 A ES 376421A ES 376421 A ES376421 A ES 376421A ES 376421 A1 ES376421 A1 ES 376421A1
Authority
ES
Spain
Prior art keywords
carboxyl group
carbon atoms
acyl radical
group
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES376421A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Original Assignee
Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR6906348A external-priority patent/FR2035766A1/en
Priority claimed from FR6938912A external-priority patent/FR2068427A1/en
Application filed by Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA filed Critical Societe Industrielle pour la Fabrication des Antibiotiques SA SIFA
Publication of ES376421A1 publication Critical patent/ES376421A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Procedure for the preparation of new derivatives of pregnane that correspond to the general formula **(See formula)** in which R represents a hydrogen atom or the acyl radical of a saturated, linear or branched aliphatic carboxylic acid, comprising from 2 to 6 carbon atoms and possibly substituted by a free (-COOH) or salified (-COOA) carboxyl group (A being an alkali metal or ammonium), said carboxyl group being separated from the -CO- group of the acyl radical by at least two carbon atoms, a process characterized in that fluoro-9-tetrahydroxy is reacted in an acetalization reaction -11beta, 16alpha, 17.21, pregnadien-1,4 dione-3.20 with acrolein in the presence of an acid catalyst and why fluoro-9 dihydroxy-11beta-21 (propenylidene-2 dioxy) -16alpha is well isolated, 17 pregnadien-1,4 dione-3,20, said product is well reacted, in an esterification reaction, with the anhydride of an acid of formula R'-OH in which R'represents the acyl radical of a carboxylic acid linear or branched, saturated aliphatic comprising 2 to 6 carbon atoms and optionally substituted by a free carboxyl group (-COOH), said carboxyl group being separated from the -CO- group of the acyl radical by at least 2 carbon atoms and, eventually, when the R'radical comprises a free carboxyl group, it is salified with help of an alkaline agent the product obtained. (Machine-translation by Google Translate, not legally binding)
ES376421A 1969-03-07 1970-02-10 Pregnane derivatives and process for preparation thereof Expired ES376421A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR6906348A FR2035766A1 (en) 1969-03-07 1969-03-07 Preparation of prenane derivs
FR6938912A FR2068427A1 (en) 1969-11-13 1969-11-13 Preparation of prenane derivs

Publications (1)

Publication Number Publication Date
ES376421A1 true ES376421A1 (en) 1972-04-16

Family

ID=26214890

Family Applications (1)

Application Number Title Priority Date Filing Date
ES376421A Expired ES376421A1 (en) 1969-03-07 1970-02-10 Pregnane derivatives and process for preparation thereof

Country Status (9)

Country Link
JP (1) JPS4843910B1 (en)
BE (1) BE746965A (en)
DK (1) DK122812B (en)
ES (1) ES376421A1 (en)
FI (1) FI47573C (en)
GB (1) GB1292269A (en)
NL (1) NL7001308A (en)
NO (1) NO134746C (en)
SE (1) SE360652B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112004557A (en) * 2018-01-08 2020-11-27 里珍纳龙药品有限公司 Steroid compounds and antibody conjugates thereof

Also Published As

Publication number Publication date
JPS4843910B1 (en) 1973-12-21
FI47573C (en) 1974-01-10
BE746965A (en) 1970-09-07
NO134746C (en) 1976-12-08
DK122812B (en) 1972-04-17
GB1292269A (en) 1972-10-11
NO134746B (en) 1976-08-30
FI47573B (en) 1973-10-01
SE360652B (en) 1973-10-01
NL7001308A (en) 1970-09-09
DE2006635A1 (en) 1970-09-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19870204