GB1131443A - A process for the manufacture of steroids - Google Patents
A process for the manufacture of steroidsInfo
- Publication number
- GB1131443A GB1131443A GB839167A GB839167A GB1131443A GB 1131443 A GB1131443 A GB 1131443A GB 839167 A GB839167 A GB 839167A GB 839167 A GB839167 A GB 839167A GB 1131443 A GB1131443 A GB 1131443A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- methylene
- hydroxy
- hydrogen atom
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Details Of Garments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,131,443. Steroids. F. HOFFMANN-LA ROCHE & CO. A.G. 22 Feb., 1967 [23 Dec., 1966], No. 8391/67. Heading C2U. The invention comprises a 4-chloro-steroid of the general formula wherein R<SP>1</SP> represents a fluorine, chlorine or bromine atom or a lower alkyl group, Q represents an oxo group or a 1,2-alkylenedioxy group and M represents a structure of the formula wherein R<SP>2</SP> represent a hydrogen or fluorine atom, R<SP>3</SP> represents a hydrogen atom or a hydroxy, lower alkanoyloxy or lower alkyl group, R<SP>4</SP> represents a hydrogen atom or a lower alkyl group, R<SP>5</SP> and R<SP>9</SP> each represent a hydrogen atom or a lower alkanoyl group, R<SP>6</SP> represents a hydrogen atom or a lower alkyl or ethynyl group, R<SP>7</SP> represents a hydrogen atom or a methyl group, R<SP>8</SP> represents a hydrogen, fluorine, chlorine or bromine atom, R<SP>10</SP> represents a hydrogen atom or an α-hydroxy or lower alkyl group and R<SP>11</SP> represents a hydroxy group or R<SP>10</SP> and R<SP>11</SP> together represent a grouping of the formula Y represents a methylene, #-hydroxy-methylene, α-hydroxy-methylene or carbonyl group and Z represents a methylene, #-hydroxymethylene, α-hydroxymethylene or carbonyl group or, where R<SP>8</SP> represents a chlorine atom, a #-chloro-methylene group (Z being an α- hydroxy-methylene or methylene group only when R<SP>8</SP> represents a hydrogen atom) and wherein a double bond may be present in 1,2- position and a process for the preparation of 4-chloro-steroids of the general formula wherein R<SP>1</SP> and Q are as defined above and M represents the remainder of the A and B rings as well as the C and D rings of the steroid molecule by treating a steroid of the general formula with chlorine either in the presence of a proton acceptor or followed by the addition of a proton acceptor, and if desired converting the 3-oxo group in the product into a 1,2-alkylenedioxy group. Subsequently any free hydroxy groups in the 4-chloro steroid product may be esterified, and dehydrogenation may be effected in 1,2- position. Pharmaceutical and veterinary compositions containing the above novel compounds and having progestational, anti-inflammatory or thymolytic activity are administered orally, parenterally or topically.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52920066A | 1966-02-23 | 1966-02-23 | |
US60414366A | 1966-12-23 | 1966-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1131443A true GB1131443A (en) | 1968-10-23 |
Family
ID=27062956
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1851068A Expired GB1131445A (en) | 1966-02-23 | 1967-02-22 | Novel steroids |
GB1850968A Expired GB1131444A (en) | 1966-02-23 | 1967-02-22 | Novel steroids |
GB839167A Expired GB1131443A (en) | 1966-02-23 | 1967-02-22 | A process for the manufacture of steroids |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1851068A Expired GB1131445A (en) | 1966-02-23 | 1967-02-22 | Novel steroids |
GB1850968A Expired GB1131444A (en) | 1966-02-23 | 1967-02-22 | Novel steroids |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS493984B1 (en) |
AT (1) | AT280492B (en) |
BE (1) | BE694288A (en) |
CH (2) | CH492688A (en) |
DE (1) | DE1618493A1 (en) |
DK (1) | DK118461B (en) |
ES (1) | ES337169A1 (en) |
FI (1) | FI45319C (en) |
FR (2) | FR8004M (en) |
GB (3) | GB1131445A (en) |
GR (1) | GR36816B (en) |
IL (1) | IL27472A (en) |
NL (1) | NL6702793A (en) |
NO (1) | NO128764B (en) |
SE (2) | SE337370B (en) |
YU (1) | YU32529B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH536294A (en) * | 1968-09-13 | 1973-04-30 | Schering Ag | Process for the preparation of racemic and optically active 4,6-dichloro-4,6-estradienes |
-
1967
- 1967-02-16 CH CH231667A patent/CH492688A/en not_active IP Right Cessation
- 1967-02-16 CH CH1777069A patent/CH499505A/en not_active IP Right Cessation
- 1967-02-18 DE DE19671618493 patent/DE1618493A1/en active Pending
- 1967-02-20 FR FR95555A patent/FR8004M/fr not_active Expired
- 1967-02-20 BE BE694288D patent/BE694288A/xx unknown
- 1967-02-20 AT AT166067A patent/AT280492B/en not_active IP Right Cessation
- 1967-02-21 FR FR95707A patent/FR1513740A/en not_active Expired
- 1967-02-22 GB GB1851068A patent/GB1131445A/en not_active Expired
- 1967-02-22 FI FI53567A patent/FI45319C/en active
- 1967-02-22 YU YU33067A patent/YU32529B/en unknown
- 1967-02-22 NO NO16697267A patent/NO128764B/no unknown
- 1967-02-22 ES ES337169A patent/ES337169A1/en not_active Expired
- 1967-02-22 IL IL2747267A patent/IL27472A/en unknown
- 1967-02-22 GR GR670136816A patent/GR36816B/en unknown
- 1967-02-22 GB GB1850968A patent/GB1131444A/en not_active Expired
- 1967-02-22 GB GB839167A patent/GB1131443A/en not_active Expired
- 1967-02-23 DK DK98467A patent/DK118461B/en unknown
- 1967-02-23 SE SE251267A patent/SE337370B/xx unknown
- 1967-02-23 JP JP1125067A patent/JPS493984B1/ja active Pending
- 1967-02-23 SE SE1693270A patent/SE354861B/xx unknown
- 1967-02-23 NL NL6702793A patent/NL6702793A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ES337169A1 (en) | 1968-02-16 |
NO128764B (en) | 1974-01-07 |
FR8004M (en) | 1970-07-27 |
IL27472A (en) | 1972-03-28 |
FI45319B (en) | 1972-01-31 |
DE1618493A1 (en) | 1970-10-29 |
YU33067A (en) | 1974-08-31 |
NL6702793A (en) | 1967-08-24 |
BE694288A (en) | 1967-08-21 |
YU32529B (en) | 1975-02-28 |
AT280492B (en) | 1970-04-10 |
GB1131445A (en) | 1968-10-23 |
FR1513740A (en) | 1968-02-16 |
FI45319C (en) | 1972-05-10 |
CH499505A (en) | 1970-11-30 |
SE337370B (en) | 1971-08-09 |
GB1131444A (en) | 1968-10-23 |
JPS493984B1 (en) | 1974-01-29 |
DK118461B (en) | 1970-08-24 |
SE354861B (en) | 1973-03-26 |
CH492688A (en) | 1970-06-30 |
GR36816B (en) | 1969-03-11 |
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