GB1268241A - Linear anthrasteroids - Google Patents

Linear anthrasteroids

Info

Publication number
GB1268241A
GB1268241A GB1130569A GB1130569A GB1268241A GB 1268241 A GB1268241 A GB 1268241A GB 1130569 A GB1130569 A GB 1130569A GB 1130569 A GB1130569 A GB 1130569A GB 1268241 A GB1268241 A GB 1268241A
Authority
GB
United Kingdom
Prior art keywords
oxo
diol
androstane
acetyloxy
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1130569A
Inventor
Sadao Aoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB1268241A publication Critical patent/GB1268241A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G7/00—Flower holders or the like
    • A47G7/02—Devices for supporting flower-pots or cut flowers
    • A47G7/08—Covers for flower-pots, e.g. ornamental pots
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/44—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed ring system having more than three rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

1,268,241. Linear anthrasteroids. SHIONOGI & CO. Ltd. 3 March, 1969 [1 March, 1968], No. 11305/69. Headings C2C and C2U. Novel compounds I (in which X is where the alkyl group has 1-4C, 1-4C alkylenedioxy or oxo; Y<SP>11</SP> is or 1-4C alkylenedithio or benzylthio when the conjugated diene structure is present in the C ring; D is H or halo; a wavy line represents a or # configuration; and a broken line represents an optional further bond) and when the compounds are acylable, their esters including cyclic esters are prepared by general methods as illustrated in the following sequences in which Ac is an acyl group. Steroid intermediates isolated are 3α, 20#- diacetyloxy - 8α,9α - dihydroxy - 5α - pregnan - 11- 11 - one; 8α,9α - dihydroxy - 5α - androstanone; 3# - acetyloxy - 11 - oxo - 5α - androstane- 8α,9α - diol; 17# - acetyloxy - 11 - oxo - 5α - androstane - 8α,9α - diol, 3#,17# - diacetyloxy- 11 - oxo - 5α - androstane - 8α,9α - diol and 20# - acetyloxy - 11 - oxo - pregnane - 8α,9α - diol all prepared by reaction of the appropriate 8(9)- ene with ruthenium or osmium tetroxide. Other intermediates isolated are the 8,9,11- trioxo - 8,9 - seco - steroids corresponding to the above steroid intermediates prepared by reaction of said steroid intermediates with lead tetraacetate or a periodate. Pharmaceutical compositions comprise a compound I together with a suitable pharmaceutical diluent or carrier and are administered orally or parenterally as anti-androgenic agents; diuretics; and anti-fertility, anti-inflammatory, anti-pituitary and anti-lipemic agents.
GB1130569A 1968-03-01 1969-03-03 Linear anthrasteroids Expired GB1268241A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1337568 1968-03-01

Publications (1)

Publication Number Publication Date
GB1268241A true GB1268241A (en) 1972-03-22

Family

ID=11831335

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1130569A Expired GB1268241A (en) 1968-03-01 1969-03-03 Linear anthrasteroids

Country Status (3)

Country Link
DE (1) DE1910768A1 (en)
FR (1) FR2003044B1 (en)
GB (1) GB1268241A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874898A (en) * 1987-07-31 1989-10-17 Shionogi And Co., Ltd. Patent Department Novel substituted anthrasteroid derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874898A (en) * 1987-07-31 1989-10-17 Shionogi And Co., Ltd. Patent Department Novel substituted anthrasteroid derivatives

Also Published As

Publication number Publication date
DE1910768A1 (en) 1969-10-02
FR2003044A1 (en) 1969-11-07
FR2003044B1 (en) 1973-01-12

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