GB1292785A - Derivatives of dexa- and beta-methasone, their production and use - Google Patents

Derivatives of dexa- and beta-methasone, their production and use

Info

Publication number
GB1292785A
GB1292785A GB22811/71A GB2281171A GB1292785A GB 1292785 A GB1292785 A GB 1292785A GB 22811/71 A GB22811/71 A GB 22811/71A GB 2281171 A GB2281171 A GB 2281171A GB 1292785 A GB1292785 A GB 1292785A
Authority
GB
United Kingdom
Prior art keywords
dexamethasone
betamethasone
beta
prepared
methasone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22811/71A
Inventor
Giorgio Piffer
Mario Pinza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISF SpA
Original Assignee
ISF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISF SpA filed Critical ISF SpA
Publication of GB1292785A publication Critical patent/GB1292785A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1292785 Esters of dexamethasone and betamethasone ISF SpA 19 April 1971 [17 Oct 1970] 22811/71 Heading C2U Novel steroids of the formula (wherein R 1 is a saturated or unsaturated hydrocarbon group of 8-14 carbon atoms and n is 3, 4, 5, 6 or 7) are prepared by reacting beta- W ethasone or dexamethasone, or an ester thereof e.g. a 21-mesylate, with the appropriate acid R 1 CH = CH(CH 2 ) n CO 2 H or a salt thereof. Suitable acids include oleic, linoleic, linolenic and arachidonic acids. Dexamethasone and betamethasone 21-mesylates are prepared from the free 21-ols and mesyl chloride. The novel steroids are stated to possess antiinflammatory activity, and they may be made up into pharmaceutical compositions with suitable carriers.
GB22811/71A 1970-10-17 1971-04-19 Derivatives of dexa- and beta-methasone, their production and use Expired GB1292785A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT31143/70A IT1043956B (en) 1970-10-17 1970-10-17 21 ESTERS OF UNSATURATED FATTY ACIDS OF DESA AND BETA METAZONE

Publications (1)

Publication Number Publication Date
GB1292785A true GB1292785A (en) 1972-10-11

Family

ID=11233166

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22811/71A Expired GB1292785A (en) 1970-10-17 1971-04-19 Derivatives of dexa- and beta-methasone, their production and use

Country Status (6)

Country Link
JP (1) JPS5125023B1 (en)
BE (1) BE764130A (en)
DE (1) DE2113163C3 (en)
FR (1) FR2112302B1 (en)
GB (1) GB1292785A (en)
IT (1) IT1043956B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762175B2 (en) 1997-01-24 2004-07-13 Norsk Hydro Asa Fatty acid derivatives
US7390796B2 (en) 2002-10-08 2008-06-24 Sepracor Inc. Fatty acid modified forms of glucocorticoids
WO2008115069A2 (en) * 2007-03-20 2008-09-25 Clavis Pharma Asa Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5879533U (en) * 1981-11-26 1983-05-30 大熊　英彦 envelope with pocket
JPS62188438U (en) * 1986-05-19 1987-12-01

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762175B2 (en) 1997-01-24 2004-07-13 Norsk Hydro Asa Fatty acid derivatives
US7390796B2 (en) 2002-10-08 2008-06-24 Sepracor Inc. Fatty acid modified forms of glucocorticoids
WO2008115069A2 (en) * 2007-03-20 2008-09-25 Clavis Pharma Asa Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents
WO2008115069A3 (en) * 2007-03-20 2008-11-13 Clavis Pharma As Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents
AU2008227246B2 (en) * 2007-03-20 2012-06-14 Clavis Pharma Asa Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents

Also Published As

Publication number Publication date
DE2113163A1 (en) 1972-04-20
FR2112302B1 (en) 1974-10-18
DE2113163B2 (en) 1974-02-07
IT1043956B (en) 1980-02-29
FR2112302A1 (en) 1972-06-16
DE2113163C3 (en) 1974-09-12
JPS5125023B1 (en) 1976-07-28
BE764130A (en) 1971-08-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee