GB1152984A - New Methanobenzazocine Derivatives and Processes for their production - Google Patents
New Methanobenzazocine Derivatives and Processes for their productionInfo
- Publication number
- GB1152984A GB1152984A GB1966166A GB1966166A GB1152984A GB 1152984 A GB1152984 A GB 1152984A GB 1966166 A GB1966166 A GB 1966166A GB 1966166 A GB1966166 A GB 1966166A GB 1152984 A GB1152984 A GB 1152984A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methanobenzazocine
- derivatives
- products
- iii
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Clamps And Clips (AREA)
- Saccharide Compounds (AREA)
- Connections Arranged To Contact A Plurality Of Conductors (AREA)
Abstract
1,152,984. Methanobenzazocine derivatives. J. R. GEIGY A.G. 5 May, 1966 [5 May, 1965], No. 19661/66. Heading C2C. Compounds of the formula (wherein R 1 is H, halogen, CF 3 or OH; R 2 is H, OH, C 1-4 alkoxy or C 1-6 alkanoyloxy; Y is H or cycloalkylmethyl, or C 1-5 alkyl which may be phenyl- or aminophenyl-substituted; and X is H or C 1-3 alkyl) are prepared by reduction of compounds of the Formulµ II and III (wherein one Z is -CO- and the other is -CO- or -CH 2 -) compounds (III) giving products wherein X is H only. 8-Hydroxy products may be alkylated or alkanoylated and 8-alkylatesalkanoates may be hydrolysed. Acid-addition salts of the products may be prepared; and the products may be resolved into their d- and lforms. Starting materials of the Formulµ (II) and (III) are prepared, for example, by methods illustrated in the following reaction sequences The methanobenzazocine derivatives of the invention, which are stated to have analgetic and anti-tussive action, and to be, in some instances, antagonists of morphine, may be made up into pharmaceutical compositions for oral or parenteral administration with suitable carriers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45347265A | 1965-05-05 | 1965-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1152984A true GB1152984A (en) | 1969-05-21 |
Family
ID=23800715
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1966066A Expired GB1154570A (en) | 1965-05-05 | 1966-05-05 | New Methanobenzazocine Derivatives and processes for their production |
| GB1966166A Expired GB1152984A (en) | 1965-05-05 | 1966-05-05 | New Methanobenzazocine Derivatives and Processes for their production |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1966066A Expired GB1154570A (en) | 1965-05-05 | 1966-05-05 | New Methanobenzazocine Derivatives and processes for their production |
Country Status (12)
| Country | Link |
|---|---|
| AT (2) | AT260265B (en) |
| BE (2) | BE680525A (en) |
| BR (2) | BR6679231D0 (en) |
| CH (2) | CH470395A (en) |
| DE (2) | DE1695073A1 (en) |
| DK (2) | DK124200B (en) |
| ES (3) | ES326315A1 (en) |
| GB (2) | GB1154570A (en) |
| IL (2) | IL25699A (en) |
| NL (2) | NL6606056A (en) |
| NO (2) | NO123387B (en) |
| SE (2) | SE341189B (en) |
-
1966
- 1966-05-04 BR BR17923166A patent/BR6679231D0/en unknown
- 1966-05-04 AT AT421866A patent/AT260265B/en active
- 1966-05-04 NO NO16286966A patent/NO123387B/no unknown
- 1966-05-04 ES ES0326315A patent/ES326315A1/en not_active Expired
- 1966-05-04 IL IL2569966A patent/IL25699A/en unknown
- 1966-05-04 ES ES0326316A patent/ES326316A1/en not_active Expired
- 1966-05-04 DE DE19661695073 patent/DE1695073A1/en active Pending
- 1966-05-04 NO NO16287066A patent/NO123721B/no unknown
- 1966-05-04 DK DK227766A patent/DK124200B/en unknown
- 1966-05-04 SE SE609966A patent/SE341189B/xx unknown
- 1966-05-04 DK DK227666A patent/DK125092B/en unknown
- 1966-05-04 NL NL6606056A patent/NL6606056A/xx unknown
- 1966-05-04 BR BR17923266A patent/BR6679232D0/en unknown
- 1966-05-04 AT AT421966A patent/AT260266B/en active
- 1966-05-04 BE BE680525D patent/BE680525A/xx unknown
- 1966-05-04 IL IL2570066A patent/IL25700A/en unknown
- 1966-05-04 ES ES0326314A patent/ES326314A1/en not_active Expired
- 1966-05-04 BE BE680526D patent/BE680526A/xx unknown
- 1966-05-04 SE SE609866A patent/SE341188B/xx unknown
- 1966-05-04 NL NL6606057A patent/NL6606057A/xx unknown
- 1966-05-04 DE DE19661695072 patent/DE1695072A1/en active Pending
- 1966-05-05 GB GB1966066A patent/GB1154570A/en not_active Expired
- 1966-05-05 CH CH649166A patent/CH470395A/en not_active IP Right Cessation
- 1966-05-05 GB GB1966166A patent/GB1152984A/en not_active Expired
- 1966-05-05 CH CH649266A patent/CH469712A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE341188B (en) | 1971-12-20 |
| GB1154570A (en) | 1969-06-11 |
| NO123387B (en) | 1971-11-08 |
| BR6679231D0 (en) | 1973-09-18 |
| DE1695073A1 (en) | 1970-12-10 |
| BE680526A (en) | 1966-11-04 |
| AT260266B (en) | 1968-02-26 |
| AT260265B (en) | 1968-02-26 |
| DE1695072A1 (en) | 1970-12-10 |
| BE680525A (en) | 1966-11-04 |
| NO123721B (en) | 1972-01-03 |
| SE341189B (en) | 1971-12-20 |
| NL6606057A (en) | 1966-11-07 |
| CH469712A (en) | 1969-03-15 |
| DK125092B (en) | 1972-12-27 |
| ES326316A1 (en) | 1967-03-01 |
| IL25699A (en) | 1971-05-26 |
| NL6606056A (en) | 1966-11-07 |
| DK124200B (en) | 1972-09-25 |
| CH470395A (en) | 1969-03-31 |
| ES326314A1 (en) | 1967-03-01 |
| IL25700A (en) | 1971-02-25 |
| ES326315A1 (en) | 1967-07-01 |
| BR6679232D0 (en) | 1973-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 49R | Reference inserted (sect. 9/1949) | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |