ES326316A1 - Procedure for the synthesis of new metanobenzazocines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the synthesis of new methanobenzazocins, of the general formula I ** (See formula) ** in which R1 means hydrogen, halogen, the trifluoromethyl group or the hydroxyl group, R 2 means hydrogen, the hydroxyl group or a lower alkoxy or lower alkanoyloxy radical, Y means hydrogen or an alkyl, alkenyl or lower alkynyl radical, the alkyl or alkenyl radical being capable of being substituted by a halogen atom, a hydroxyl group or a phenyl radical , nitrophenyl or aminophenyl, or else it means a cycloalkylenyl radical and X means hydrogen or a lower alkyl radical, and of its acid addition salts with inorganic or organic acids, characterized by being treated, a compound of the general formula II ** (See formula) ** in which a) Z means a carbonyl group and Y 'has the meaning of Y as defined in formula I, O well b) Z means a methylene or carbonylic group e Y 'has the meaning of Y, with the exception of hydrogen, even though it has such a radical instead of a methylenic or carbonyl group linked to the cyclic nitrogen atom, with an appropriate hydride, until the conversion of the amidocarbonyl group, or the amidocarconilic groups, into the methylene group, or into the methylene groups; converting, if desired, a compound of the formula I in which it means a lower alkoxy or alkanoyloxy radical, by ether cleavage or by hydrolysis, in a compound also encompassed in the formula I, in which R2 means the hydroxylic group ; or, if desired, converting such a compound, by treatment with an alkylating agent or alkanoylation corresponding to the meaning of R2, into a compound of the formula I in which R2 means a lower alkoxy or alkanoyloxy radical; and, finally, if desired, a compound of the formula I is converted to an acid addition salt with an inorganic or organic acid. (Machine-translation by Google Translate, not legally binding)