GB1021001A - Improvements in or relating to 1,2,4-oxadiazole derivatives - Google Patents

Improvements in or relating to 1,2,4-oxadiazole derivatives

Info

Publication number
GB1021001A
GB1021001A GB487564A GB487564A GB1021001A GB 1021001 A GB1021001 A GB 1021001A GB 487564 A GB487564 A GB 487564A GB 487564 A GB487564 A GB 487564A GB 1021001 A GB1021001 A GB 1021001A
Authority
GB
United Kingdom
Prior art keywords
group
amino
carbethoxyamino
hydroxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB487564A
Inventor
Giuseppe Palazzo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB487564A priority Critical patent/GB1021001A/en
Publication of GB1021001A publication Critical patent/GB1021001A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The invention comprises compounds of formula <FORM:1021001/C2/1> wherein X is a hydrogen or halogen atom or a hydroxy, alkoxy, amino or carbethoxyamino group, and their preparation by reaction of a compound of formula <FORM:1021001/C2/2> wherein X1 is the same as X, other than an amino or carbethoxyamino group, or is a nitro group, with an anhydrous alkali metal acetate in the presence of glacial acetic acid and hydrolysing the acetoxymethyl derivative obtained with water or with an alcoholic alkali, or, where X1 is a nitro group, reducing this to an amino group, with simultaneous hydrolysis of the acetoxy group, and, if desired, converting the amino group to a carbethoxyamino group. 3 - p - Hydroxyphenyl - 5 - chloromethyl-1,2,4 - oxadiazole is prepared by reacting p-hydroxy - benzaldoxime with chloroacetyl chloride to give O - chloroacetyl - p - hydroxybenzaldoxime, followed by heating under reduced pressure. The compounds of the invention have analgesic, anti-inflammatory and antipyretic activity and may be used in pharmaceutical compositions in combination with a carrier.
GB487564A 1964-02-05 1964-02-05 Improvements in or relating to 1,2,4-oxadiazole derivatives Expired GB1021001A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB487564A GB1021001A (en) 1964-02-05 1964-02-05 Improvements in or relating to 1,2,4-oxadiazole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB487564A GB1021001A (en) 1964-02-05 1964-02-05 Improvements in or relating to 1,2,4-oxadiazole derivatives

Publications (1)

Publication Number Publication Date
GB1021001A true GB1021001A (en) 1966-02-23

Family

ID=9785469

Family Applications (1)

Application Number Title Priority Date Filing Date
GB487564A Expired GB1021001A (en) 1964-02-05 1964-02-05 Improvements in or relating to 1,2,4-oxadiazole derivatives

Country Status (1)

Country Link
GB (1) GB1021001A (en)

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