GB1358722A - Tetrahydronaphthyloxyaminopropanols and related compounds - Google Patents

Tetrahydronaphthyloxyaminopropanols and related compounds

Info

Publication number
GB1358722A
GB1358722A GB5491372A GB5491372A GB1358722A GB 1358722 A GB1358722 A GB 1358722A GB 5491372 A GB5491372 A GB 5491372A GB 5491372 A GB5491372 A GB 5491372A GB 1358722 A GB1358722 A GB 1358722A
Authority
GB
United Kingdom
Prior art keywords
tetrahydro
cis
naphthalenetriol
naphthalenediol
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5491372A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/203,865 external-priority patent/US3935267A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1358722A publication Critical patent/GB1358722A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C07D303/26—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds having one or more free hydroxyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1358722 Tetrahydronaphthyloxy aminopropanol derivatives E R SQUIBB & SONS Inc 28 Nov 1972 [1 Dec 1971] 54913/72 Addition to 1358721 Heading C2C The novel compound of Formula I namely 2,3-cis-1,2,3,4-tetrahydro-5-[2-hydroxy- 3 - (tert - butylamino) - propoxyl] - 2,3 - naphthalenediol is prepared by dissolving dihydronaphthalene acetate of the formula in acetic acid and water containing from 92 to 98% acetic acid, treating the solution with a silver acetate and iodine, heating the solution to a temperature within a range from 80 to 120‹ C., subjecting the resulting mixture to basic hydrolysis to form cis-5,6,7,8-tetrahydro-1,-6,7-naphthalenetriol, reacting the naphthalenetriol with an alkali metal akoxide in an alcohol solvent boiling below about 100‹ C., stirring the residue in a dipolar aprotic solvent with epichlorohydrin and reacting the resulting 2,3-cis-1,2,3,4-tetrahydro - 5 - [2,3 - epoxy propoxyl] - 2,3 -naphthalenediol with tertiary-butyl amine.
GB5491372A 1971-12-01 1972-11-28 Tetrahydronaphthyloxyaminopropanols and related compounds Expired GB1358722A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/203,865 US3935267A (en) 1970-06-22 1971-12-01 Tetrahydronaphthyloxy-aminopropanols and salts thereof

Publications (1)

Publication Number Publication Date
GB1358722A true GB1358722A (en) 1974-07-03

Family

ID=22755637

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5491372A Expired GB1358722A (en) 1971-12-01 1972-11-28 Tetrahydronaphthyloxyaminopropanols and related compounds

Country Status (3)

Country Link
CA (1) CA979926A (en)
GB (1) GB1358722A (en)
HK (1) HK34479A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338717C (en) * 1989-09-25 1996-11-12 Khashayar Karimian Nadolol

Also Published As

Publication number Publication date
HK34479A (en) 1979-06-01
CA979926A (en) 1975-12-16

Similar Documents

Publication Publication Date Title
Jackman et al. 582. Studies in nuclear magnetic resonance. Part III. Assignment of configurations of αβ-unsaturated esters and the isolation of pure trans-β-methylglutaconic acid
GB1017439A (en) New amino-acids and process for preparing same
GB1114277A (en) Sensitive photographic materials and silver halide emulsions for their preparation
GB1412130A (en) 3-substituted-morphinan derivatives
GB1476215A (en) Dibenzoxepin derivatives process for the preparation thereof and pharmaceutical compositions containing them
ES393188A1 (en) Cyclopropylmethylphenylacetic acids and derivatives
GB1358722A (en) Tetrahydronaphthyloxyaminopropanols and related compounds
GB1016356A (en) Preparation of organic peroxycarboxylic acids
GB1347433A (en) Acetophenone oxime derivatives and pharmaceutical preparations which contain the same
GB1428341A (en) Process for preparing 4,5-diphenyl-oxazol-2-one
Uehara et al. Bis-Type Cobalt (III) and Chromium (III) Complexes with Related Compounds of Iminodiacetic Acid
GB1063572A (en) A process for preparing new triamcinolone esters
ES394885A1 (en) ' -methylfluorene-2-acetic acid
ES478165A3 (en) A procedure for preparing 2,3-cis-1,2,3,4-tetrahydro-52-hydroxy-3- (terc-butil-amino) -propoxy-2,3-naftalendiol. (Machine-translation by Google Translate, not legally binding)
JPS5640643A (en) Preparation of ethyl trans-2-decen-4-ynoate
JPS5673081A (en) Preparation of tocopherol acetate
ES478867A3 (en) A procedure for preparing a substituted 2,3-cis-1,2,3,4-tetrahydro-5-2-hydroxy-3-amino-propoxy-2-3-naftalendiol. (Machine-translation by Google Translate, not legally binding)
US2242236A (en) Di-amino-alkyl-disulphoxides and process for making them
GB1319650A (en) Low temperature chlorination of acetoacetamides
GB1278475A (en) PROCESS FOR THE PREPARATION OF METHYL p-AMINOBENZENESULPHONYLCARBAMATE
Seto et al. Photo-reaction product of 5-aminotropolone in aqueous acid solution
Sherwood The basic nitrite of lanthanum
GB1479351A (en) Process for the preparation of naphthalene derivatives
GB933141A (en) Dextromethorphan n-cyclohexylsulphamate
ES286459A1 (en) Procedure for the obtaining of new antitusive compounds (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
PS Patent sealed
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977