ES421713A1 - Pregnane acid derivatives - Google Patents

Pregnane acid derivatives

Info

Publication number
ES421713A1
ES421713A1 ES421713A ES421713A ES421713A1 ES 421713 A1 ES421713 A1 ES 421713A1 ES 421713 A ES421713 A ES 421713A ES 421713 A ES421713 A ES 421713A ES 421713 A1 ES421713 A1 ES 421713A1
Authority
ES
Spain
Prior art keywords
compounds
acid derivatives
groups
free acid
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421713A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19722264003 external-priority patent/DE2264003C2/en
Priority claimed from DE2360444A external-priority patent/DE2360444A1/en
Application filed by Schering AG filed Critical Schering AG
Publication of ES421713A1 publication Critical patent/ES421713A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pregnanoic acid derivatives of the following formula < IMAGE > in which the substituents are defined in Claim 1, are prepared. These compounds are obtained by oxidising a corresponding pregnane derivative which has an aldehyde group in position 21 to the free acid using heavy metal oxides. These acids can be converted into corresponding 21-esters. The said compounds which have a saturated 1,2-bond can be dehydrogenated to DELTA <1,4>-steroids. 11-Hydroxy groups can be oxidised to 11-keto groups the 11-hydroxy group can also be esterified. It is furthermore possible to hydrolyse ester groups and to convert the free acid into the alkali metal salts. The said compounds are valuable pharmaceutical agents and can also be used as intermediates for the preparation of pharmaceuticals.
ES421713A 1972-12-22 1973-12-21 Pregnane acid derivatives Expired ES421713A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19722264003 DE2264003C2 (en) 1972-12-22 1972-12-22 New pregnanic acid derivatives, processes for their production and pharmaceutical preparations containing them
DE2360444A DE2360444A1 (en) 1973-11-30 1973-11-30 Anti-inflammatory pregnan-21-carboxylic acids - are substd 16-alpa-17-alpa-isopropylidene-dioxy 3,20-dioxo-pregn-4-ene and 1,4-diene-21-acid derivs

Publications (1)

Publication Number Publication Date
ES421713A1 true ES421713A1 (en) 1976-04-16

Family

ID=25764292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES421713A Expired ES421713A1 (en) 1972-12-22 1973-12-21 Pregnane acid derivatives

Country Status (15)

Country Link
JP (1) JPS5912680B2 (en)
AR (1) AR207751A1 (en)
AT (1) AT340072B (en)
CA (1) CA1007221A (en)
CH (2) CH618185A5 (en)
DD (1) DD108290A5 (en)
DK (1) DK135380C (en)
ES (1) ES421713A1 (en)
FI (1) FI52735C (en)
FR (1) FR2211259B1 (en)
GB (1) GB1457264A (en)
IE (1) IE38659B1 (en)
IL (1) IL43881A (en)
SE (1) SE402111B (en)
YU (1) YU35897B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2451971A1 (en) * 1974-10-31 1976-05-13 Schering Ag NEW PREGNAN 21 ACID DERIVATIVES
US4257969A (en) * 1980-01-23 1981-03-24 E. R. Squibb & Sons, Inc. 16,17-Dihydroxypregnene-21-carboxylic acids and derivatives
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives
SE8506015D0 (en) * 1985-12-19 1985-12-19 Draco Ab NOVEL 16,17-ACETALSUBSTITUTED PREGNANE 21-OIC ACID DERIVATIVES
US4897260A (en) * 1987-05-22 1990-01-30 The Rockefeller University Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same
AP157A (en) * 1990-04-25 1991-11-15 Richter Gedeon Vegyeszet Novel steroid derivatives.
CN101863952B (en) * 2010-04-30 2013-04-17 湖北葛店人福药业有限责任公司 Preparation method of budesonide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1387911A (en) * 1971-10-04 1975-03-19 Schering Ag Pregnane acid derivatives

Also Published As

Publication number Publication date
JPS5912680B2 (en) 1984-03-24
FR2211259A1 (en) 1974-07-19
FI52735C (en) 1977-11-10
ATA1073973A (en) 1977-03-15
AT340072B (en) 1977-11-25
DD108290A5 (en) 1974-09-12
JPS4994660A (en) 1974-09-09
YU332373A (en) 1981-02-28
CA1007221A (en) 1977-03-22
FR2211259B1 (en) 1976-09-03
CH618185A5 (en) 1980-07-15
IE38659B1 (en) 1978-05-10
CH618447A5 (en) 1980-07-31
YU35897B (en) 1981-08-31
AR207751A1 (en) 1976-10-29
IL43881A (en) 1976-12-31
FI52735B (en) 1977-08-01
DK135380C (en) 1977-10-03
SE402111B (en) 1978-06-19
IL43881A0 (en) 1974-06-30
GB1457264A (en) 1976-12-01
DK135380B (en) 1977-04-18
IE38659L (en) 1974-06-22

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