SE7705637L - PROCEDURE FOR THE PREPARATION OF DIBENSOXEPIN DERIVATIVES WITH THERAPEUTIC EFFECT - Google Patents

PROCEDURE FOR THE PREPARATION OF DIBENSOXEPIN DERIVATIVES WITH THERAPEUTIC EFFECT

Info

Publication number
SE7705637L
SE7705637L SE7705637A SE7705637A SE7705637L SE 7705637 L SE7705637 L SE 7705637L SE 7705637 A SE7705637 A SE 7705637A SE 7705637 A SE7705637 A SE 7705637A SE 7705637 L SE7705637 L SE 7705637L
Authority
SE
Sweden
Prior art keywords
july
compounds
derivatives
acid
dibensoxepin
Prior art date
Application number
SE7705637A
Other languages
Swedish (sv)
Inventor
K Ueno
S Kubo
T Yoshioka
H Tagawa
S Shimada
H Kojima
W Tsukada
M Tsubokawa
T Masukawa
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8333673A external-priority patent/JPS5516428B2/ja
Priority claimed from JP8374273A external-priority patent/JPS558979B2/ja
Priority claimed from JP8443473A external-priority patent/JPS5516429B2/ja
Priority claimed from JP1692674A external-priority patent/JPS5724352B2/ja
Priority claimed from JP1692774A external-priority patent/JPS50108281A/ja
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of SE7705637L publication Critical patent/SE7705637L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

1476215 Dibenzoxepin derivatives DAIICHI SEIYAKU CO Ltd 23 July 1974 [24 July 1973 25 July 1973 26 July 1973] 40074/76 Divided out of 1476214 Heading C2C The invention comprises 6,11-dihydro-11- oxodibenz[b,e]oxepin-2-acetic acid and C 1 -C 4 alkyl esters thereof, and method of preparing these compounds. The compounds are prepared by cyclizing a compound of general Formula I where R is hydrogen or a C 1 -C 4 alkyl group, optionally with a cyclizing agent (e.g. an acid), and if desired hydrolysing the product to obtain the acid. I may be obtained by reacting a phenol derivative of general formula with either phthalide (e.g. at 150-250‹ C. in the absence of a solvent) or with a halomethylbenzene derivative of formula where R<SP>1</SP> is an alkyl group, in a solvent (e.g. methanol or dimethylformamide) in the presence of a base (e.g. an alkali metal hydroxide or alkoxide). The compounds may be incorporated in pharmaceutical preparations.
SE7705637A 1973-07-24 1977-05-13 PROCEDURE FOR THE PREPARATION OF DIBENSOXEPIN DERIVATIVES WITH THERAPEUTIC EFFECT SE7705637L (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP8333673A JPS5516428B2 (en) 1973-07-24 1973-07-24
JP8374273A JPS558979B2 (en) 1973-07-25 1973-07-25
JP8443473A JPS5516429B2 (en) 1973-07-26 1973-07-26
JP1692674A JPS5724352B2 (en) 1974-02-12 1974-02-12
JP1692774A JPS50108281A (en) 1974-02-12 1974-02-12

Publications (1)

Publication Number Publication Date
SE7705637L true SE7705637L (en) 1977-05-13

Family

ID=27519864

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7409577A SE7409577L (en) 1973-07-24 1974-07-23
SE7705637A SE7705637L (en) 1973-07-24 1977-05-13 PROCEDURE FOR THE PREPARATION OF DIBENSOXEPIN DERIVATIVES WITH THERAPEUTIC EFFECT

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7409577A SE7409577L (en) 1973-07-24 1974-07-23

Country Status (11)

Country Link
AR (1) AR210725A1 (en)
BE (1) BE818055A (en)
CA (1) CA1153383A (en)
CH (6) CH605896A5 (en)
DE (1) DE2435613B2 (en)
DK (1) DK396874A (en)
FR (1) FR2245356B1 (en)
GB (2) GB1476215A (en)
NL (1) NL159381B (en)
SE (2) SE7409577L (en)
YU (5) YU204274A (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES444144A1 (en) * 1975-01-14 1977-08-16 Hoechst Ag Preparation of 6,11-dihydro-11-oxodibenz(b,e)-oxepin-alkanoic acids
DE2600768C2 (en) * 1975-02-04 1983-10-27 Hoechst Ag, 6230 Frankfurt Process for the preparation of 6,11-dihydro-11-oxodibenz [b, e] -oxepin-alkanoic acids
DE2629569A1 (en) * 1975-07-30 1977-03-31 Hoechst Ag 6,11-DIHYDRO-11-OXODIBENZY SQUARE CLAMP ON B, SQUARE BRACKET FOR OXEPIN ALKANIC ACIDS AND THEIR ESTERS AND THE PROCESS FOR THEIR PRODUCTION
US4082850A (en) 1976-04-16 1978-04-04 American Hoechst Corporation Method of treating dermal inflammations
JPS54122284A (en) * 1978-02-17 1979-09-21 Dainippon Pharmaceut Co Ltd Dibenzb,foxepin derivative
JPS56156273A (en) 1980-03-31 1981-12-02 Dainippon Pharmaceut Co Ltd Acetic derivative
DE3125374A1 (en) * 1981-06-27 1983-01-13 Hoechst Ag, 6000 Frankfurt METHOD FOR PRODUCING HETEROARYL AND DIBENZOXEPINALKAN ACIDS
US4515946A (en) * 1981-12-23 1985-05-07 Hoechst-Roussel Pharmaceuticals Inc. 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives
US4576960A (en) * 1981-12-23 1986-03-18 Hoechst Roussel Pharmaceuticals Incorporated 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin derivatives
US4526891A (en) * 1983-03-10 1985-07-02 Hoechst Roussel Pharmaceuticals Inc. Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins
US5008285A (en) * 1984-04-27 1991-04-16 Hoechst-Roussel Pharmaceuticals, Inc. (6,11-dihydro-11-oxodibenz[b,e]oxepin-yl)pentanoic acids and derivatives thereof
ATE46693T1 (en) * 1984-04-27 1989-10-15 Hoechst Roussel Pharma (6,11-DIHYDRO-11-OXODIBENZ(B,E>OXEPINYL)PENTANOLS, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR MANUFACTURE AND THEIR USE AS MEDICINES.
US4861887A (en) * 1988-01-27 1989-08-29 American Cyanamid Company Herbicidal o-(substituted, aminomethylbenzoic, nicotinic and quinoline-3-carboxylic acids, esters, and salts
US7687646B2 (en) 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
CN106518833A (en) * 2015-09-15 2017-03-22 江苏吉贝尔药业股份有限公司 New method for preparation of 6,11-dihydro-11-oxo dibenzo [b, e] oxepin-2-acetic acid

Also Published As

Publication number Publication date
CH605897A5 (en) 1978-10-13
GB1476215A (en) 1977-06-10
AR210725A1 (en) 1977-09-15
CH605899A5 (en) 1978-10-13
FR2245356B1 (en) 1978-10-13
CH605898A5 (en) 1978-10-13
DE2435613A1 (en) 1975-02-27
YU309481A (en) 1983-06-30
YU204274A (en) 1982-06-30
NL7409919A (en) 1975-01-28
FR2245356A1 (en) 1975-04-25
NL159381B (en) 1979-02-15
YU309081A (en) 1983-06-30
CA1153383A (en) 1983-09-06
BE818055A (en) 1974-11-18
SE7409577L (en) 1975-01-27
GB1476214A (en) 1977-06-10
DE2435613B2 (en) 1979-07-05
AU7143174A (en) 1976-01-22
DK396874A (en) 1975-03-17
CH605896A5 (en) 1978-10-13
YU309281A (en) 1983-06-30
YU309381A (en) 1983-06-30
CH605900A5 (en) 1978-10-13
CH594658A5 (en) 1978-01-13

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