GB0909904D0 - Product - Google Patents

Product

Info

Publication number
GB0909904D0
GB0909904D0 GBGB0909904.5A GB0909904A GB0909904D0 GB 0909904 D0 GB0909904 D0 GB 0909904D0 GB 0909904 A GB0909904 A GB 0909904A GB 0909904 D0 GB0909904 D0 GB 0909904D0
Authority
GB
United Kingdom
Prior art keywords
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0909904.5A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affitech AS
Original Assignee
Affitech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affitech AS filed Critical Affitech AS
Priority to GBGB0909904.5A priority Critical patent/GB0909904D0/en
Publication of GB0909904D0 publication Critical patent/GB0909904D0/en
Priority to JP2012514538A priority patent/JP2012529281A/ja
Priority to PCT/GB2010/050969 priority patent/WO2010142990A1/en
Priority to CN2010800351667A priority patent/CN102549017A/zh
Priority to BRPI1011005A priority patent/BRPI1011005A2/pt
Priority to EA201171463A priority patent/EA201171463A1/ru
Priority to EP10724121A priority patent/EP2440580A1/en
Priority to US12/797,052 priority patent/US8637017B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GBGB0909904.5A 2009-06-09 2009-06-09 Product Ceased GB0909904D0 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GBGB0909904.5A GB0909904D0 (en) 2009-06-09 2009-06-09 Product
JP2012514538A JP2012529281A (ja) 2009-06-09 2010-06-09 抗ＥｐＣＡＭ抗体
PCT/GB2010/050969 WO2010142990A1 (en) 2009-06-09 2010-06-09 ANTI-EpCAM ANTIBODIES
CN2010800351667A CN102549017A (zh) 2009-06-09 2010-06-09 抗-EpCAM抗体
BRPI1011005A BRPI1011005A2 (pt) 2009-06-09 2010-06-09 anticorpos anti-epcam
EA201171463A EA201171463A1 (ru) 2009-06-09 2010-06-09 АНТИТЕЛА ПРОТИВ EpCAM
EP10724121A EP2440580A1 (en) 2009-06-09 2010-06-09 ANTI-EpCAM ANTIBODIES
US12/797,052 US8637017B2 (en) 2009-06-09 2010-06-09 Anti-EpCAM antibodies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0909904.5A GB0909904D0 (en) 2009-06-09 2009-06-09 Product

Publications (1)

Publication Number Publication Date
GB0909904D0 true GB0909904D0 (en) 2009-07-22

Family

ID=40937119

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0909904.5A Ceased GB0909904D0 (en) 2009-06-09 2009-06-09 Product

Country Status (8)

Country Link
US (1) US8637017B2 (enExample)
EP (1) EP2440580A1 (enExample)
JP (1) JP2012529281A (enExample)
CN (1) CN102549017A (enExample)
BR (1) BRPI1011005A2 (enExample)
EA (1) EA201171463A1 (enExample)
GB (1) GB0909904D0 (enExample)
WO (1) WO2010142990A1 (enExample)

Families Citing this family (51)

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EP2829283B1 (en) 2003-04-30 2017-06-07 Universität Zürich Methods for treating cancer using an immunotoxin
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
MY162056A (en) 2006-10-12 2017-05-31 Univ Tokyo Diagnosis and treatment of cancer using anti -ereg antibody
EP2436397B1 (en) 2009-05-29 2017-05-10 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition containing antagonist of egf family ligand as component
AU2012228100B2 (en) 2011-03-17 2016-09-08 The University Of Birmingham Re-directed immunotherapy
WO2012158818A2 (en) 2011-05-16 2012-11-22 Fabion Pharmaceuticals, Inc. Multi-specific fab fusion proteins and methods of use
TWI593705B (zh) * 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
TWI485161B (zh) * 2012-03-02 2015-05-21 Academia Sinica 抗上皮細胞黏著分子（ＥｐＣＡＭ）抗體及其使用方法
HUE032569T2 (en) * 2012-09-19 2017-09-28 Abbvie Biotherapeutics Inc Methods for identifying antibodies with reduced immunogenicity
CN103387990B (zh) * 2012-09-24 2016-01-06 厦门大学 上皮细胞粘附分子的核酸适体EpCAM B及其制备方法
US20140248292A1 (en) * 2013-03-04 2014-09-04 Oslo Universitetssykehus Hf Compositions and methods for treating cancer
WO2014138449A1 (en) * 2013-03-06 2014-09-12 Merrimack Pharmaceuticals, Inc. Anti-c-met tandem fc bispecific antibodies
CN105188762A (zh) * 2013-04-12 2015-12-23 维文蒂阿生物公司 用于肝细胞癌检测和治疗的组合物和方法
CN103275226B (zh) * 2013-06-09 2017-08-29 中国科学技术大学 特异性抗人上皮细胞粘附分子（EpCAM）的单克隆抗体的制备、鉴定及应用
TW201542591A (zh) * 2013-06-24 2015-11-16 Chugai Pharmaceutical Co Ltd 含有以人源化抗Ｅｐｉｒｅｇｕｌｉｎ抗體爲有效成分的腺癌以外的非小細胞肺癌之治療劑
MX2016004239A (es) 2013-10-02 2016-11-14 Viventia Bio Inc Anticuerpos anti-epcam y métodos de uso.
WO2016145354A1 (en) 2015-03-12 2016-09-15 Viventia Bio Inc. Dosing strategies for targeting epcam positive bladder cancer
WO2016145349A1 (en) 2015-03-12 2016-09-15 Viventia Bio Inc. Methods of treatment for epcam positive bladder cancer
EP3277716B1 (en) * 2015-04-03 2020-06-24 XOMA Technology Ltd. Treatment of cancer using inhibitors of tgf-beta and pd-1
EP3328897A1 (en) * 2015-07-31 2018-06-06 Sutro Biopharma, Inc. ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EPCAM ANTIBODIES
CN109476756B (zh) 2016-03-15 2022-05-31 埃泰美德(香港)有限公司 一种多特异性Fab融合蛋白及其用途
SG11201900634VA (en) 2016-07-26 2019-02-27 Tessa Therapeutics Pte Ltd Chimeric antigen receptor
CN107814846A (zh) * 2016-11-14 2018-03-20 杭州华得森生物技术有限公司 针对EpCAM和Cytokeratin5的特异性抗体及其制备方法
WO2018178055A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
KR20240167101A (ko) * 2017-09-07 2024-11-26 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 넥틴4에 결합하는 단백질
PE20210375A1 (es) 2018-02-08 2021-03-02 Dragonfly Therapeutics Inc Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales
FI3749346T3 (fi) 2018-02-08 2024-09-04 Dragonfly Therapeutics Inc Nkg2d-reseptoriin kohdistuvat vasta-aineen vaihtelevan domeenin yhdistelmät
MX2020008684A (es) 2018-02-20 2020-12-07 Dragonfly Therapeutics Inc Proteinas de union multiespecificas que se unen a cd33, nkg2d y cd16 y metodos de uso.
CN108484771A (zh) * 2018-04-24 2018-09-04 南京市妇幼保健院 EpCAM单域抗体G7
JPWO2019244973A1 (ja) 2018-06-20 2021-07-08 中外製薬株式会社 標的細胞に対する免疫反応を活性化する方法およびその組成物
GB201811410D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd OX40 Binding molecules
WO2020018964A1 (en) 2018-07-20 2020-01-23 Fred Hutchinson Cancer Research Center Compositions and methods for controlled expression of antigen-specific receptors
US12384851B2 (en) 2018-08-08 2025-08-12 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
JP7482363B2 (ja) 2018-08-08 2024-05-14 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及び腫瘍関連抗原に結合するタンパク質
US12460000B2 (en) 2018-09-07 2025-11-04 Itabmed (Hk) Limited Anti-CD19 and anti-CD3 bispecific antigen binding proteins and uses thereof
TWI897855B (zh) * 2018-10-26 2025-09-21 美商免疫遺傳股份有限公司 Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途
WO2020131697A2 (en) 2018-12-17 2020-06-25 Revitope Limited Twin immune cell engager
CN113597432B (zh) * 2019-04-22 2023-05-02 江苏恒瑞医药股份有限公司 抗EpCAM抗体及其应用
CN110950959B (zh) * 2020-02-25 2020-07-03 和铂医药(上海)有限责任公司 靶向EpCAM的抗体及其制备和应用
CN118063614A (zh) * 2020-03-11 2024-05-24 南京融捷康生物科技有限公司 可特异性结合EpCAM的单域抗体及其应用
TW202208428A (zh) 2020-05-06 2022-03-01 美商蜻蜓醫療公司 結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質
US11919944B2 (en) 2020-05-11 2024-03-05 Augmenta Biosciences, Inc. Antibodies for SARS-CoV-2 and uses thereof
CN112359052B (zh) * 2020-08-20 2023-01-03 山东兴瑞生物科技有限公司 抗EpCAM嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用
TW202241967A (zh) * 2021-01-11 2022-11-01 美商索特里亞生物治療藥物公司 基於茚地那韋的化學二聚化ｔ細胞銜接器組成物
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
AR126009A1 (es) 2021-06-02 2023-08-30 Hoffmann La Roche Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam
CN113563474B (zh) * 2021-06-11 2023-05-02 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） EpCAM-CD16-NKG2D三特异性抗体及其应用
WO2024082269A1 (zh) * 2022-10-21 2024-04-25 武汉友芝友生物制药股份有限公司 双特异性抗体在免疫细胞治疗方面的应用
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CN119409829B (zh) * 2024-11-15 2025-08-22 康元医疗科技(大连)有限公司 抗EpCAM纳米抗体及其应用

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Also Published As

Publication number Publication date
WO2010142990A1 (en) 2010-12-16
EA201171463A1 (ru) 2012-07-30
CN102549017A (zh) 2012-07-04
US20100310463A1 (en) 2010-12-09
BRPI1011005A2 (pt) 2018-03-06
US8637017B2 (en) 2014-01-28
JP2012529281A (ja) 2012-11-22
EP2440580A1 (en) 2012-04-18

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)