CN102549017A - 抗-EpCAM抗体 - Google Patents
抗-EpCAM抗体 Download PDFInfo
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- CN102549017A CN102549017A CN2010800351667A CN201080035166A CN102549017A CN 102549017 A CN102549017 A CN 102549017A CN 2010800351667 A CN2010800351667 A CN 2010800351667A CN 201080035166 A CN201080035166 A CN 201080035166A CN 102549017 A CN102549017 A CN 102549017A
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| GBGB0909904.5A GB0909904D0 (en) | 2009-06-09 | 2009-06-09 | Product |
| PCT/GB2010/050969 WO2010142990A1 (en) | 2009-06-09 | 2010-06-09 | ANTI-EpCAM ANTIBODIES |
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| Country | Link |
|---|---|
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| EP (1) | EP2440580A1 (enExample) |
| JP (1) | JP2012529281A (enExample) |
| CN (1) | CN102549017A (enExample) |
| BR (1) | BRPI1011005A2 (enExample) |
| EA (1) | EA201171463A1 (enExample) |
| GB (1) | GB0909904D0 (enExample) |
| WO (1) | WO2010142990A1 (enExample) |
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| CN107814846A (zh) * | 2016-11-14 | 2018-03-20 | 杭州华得森生物技术有限公司 | 针对EpCAM和Cytokeratin5的特异性抗体及其制备方法 |
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- 2010-06-09 CN CN2010800351667A patent/CN102549017A/zh active Pending
- 2010-06-09 BR BRPI1011005A patent/BRPI1011005A2/pt not_active IP Right Cessation
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- 2010-06-09 EA EA201171463A patent/EA201171463A1/ru unknown
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| CN103409427B (zh) * | 2012-09-24 | 2016-05-18 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM C及其制备方法 |
| CN102827845A (zh) * | 2012-09-24 | 2012-12-19 | 厦门大学 | 上皮细胞粘附分子的核酸适体及其制备方法 |
| CN103387988A (zh) * | 2012-09-24 | 2013-11-13 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM Ccut及其制备方法 |
| CN103387989A (zh) * | 2012-09-24 | 2013-11-13 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM D及其制备方法 |
| CN103387990A (zh) * | 2012-09-24 | 2013-11-13 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM B及其制备方法 |
| CN103409427A (zh) * | 2012-09-24 | 2013-11-27 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM C及其制备方法 |
| CN102827845B (zh) * | 2012-09-24 | 2014-05-07 | 厦门大学 | 上皮细胞粘附分子的核酸适体及其制备方法 |
| CN103387990B (zh) * | 2012-09-24 | 2016-01-06 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM B及其制备方法 |
| CN103387989B (zh) * | 2012-09-24 | 2016-05-18 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM D及其制备方法 |
| CN103387988B (zh) * | 2012-09-24 | 2016-01-06 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM Ccut及其制备方法 |
| CN103275226A (zh) * | 2013-06-09 | 2013-09-04 | 中国科学技术大学 | 特异性抗人上皮细胞粘附分子（EpCAM）的单克隆抗体的制备、鉴定及应用 |
| CN107814846A (zh) * | 2016-11-14 | 2018-03-20 | 杭州华得森生物技术有限公司 | 针对EpCAM和Cytokeratin5的特异性抗体及其制备方法 |
| CN108484771A (zh) * | 2018-04-24 | 2018-09-04 | 南京市妇幼保健院 | EpCAM单域抗体G7 |
| WO2020216210A1 (zh) * | 2019-04-22 | 2020-10-29 | 江苏恒瑞医药股份有限公司 | 抗EpCAM抗体及其应用 |
| CN113597432A (zh) * | 2019-04-22 | 2021-11-02 | 江苏恒瑞医药股份有限公司 | 抗EpCAM抗体及其应用 |
| CN112359052A (zh) * | 2020-08-20 | 2021-02-12 | 山东兴瑞生物科技有限公司 | 抗EpCAM嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用 |
| CN112359052B (zh) * | 2020-08-20 | 2023-01-03 | 山东兴瑞生物科技有限公司 | 抗EpCAM嵌合抗原受体的编码基因、制备方法、具有该基因的质粒、免疫细胞及其应用 |
| CN113563474A (zh) * | 2021-06-11 | 2021-10-29 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | EpCAM-CD16-NKG2D三特异性抗体及其应用 |
| CN113563474B (zh) * | 2021-06-11 | 2023-05-02 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | EpCAM-CD16-NKG2D三特异性抗体及其应用 |
| WO2024082269A1 (zh) * | 2022-10-21 | 2024-04-25 | 武汉友芝友生物制药股份有限公司 | 双特异性抗体在免疫细胞治疗方面的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2440580A1 (en) | 2012-04-18 |
| WO2010142990A1 (en) | 2010-12-16 |
| BRPI1011005A2 (pt) | 2018-03-06 |
| US8637017B2 (en) | 2014-01-28 |
| EA201171463A1 (ru) | 2012-07-30 |
| JP2012529281A (ja) | 2012-11-22 |
| GB0909904D0 (en) | 2009-07-22 |
| US20100310463A1 (en) | 2010-12-09 |
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