FR3078886A1 - MEDICAMENT FOR TREATING TOOTHBORNE AND METHOD FOR PREPARING THE SAME - Google Patents

Abstract

The present invention discloses a medicament for treating toothache and its method of preparation. The medicine for treating toothache comprises from 15 to 25 parts by weight of Fructus forsythiae, from 10 to 25 parts by weight of Lonicera japonica, from 13 to 20 parts by weight of Radix Paeoniae Rubra, from 12 to 20 parts by weight of Angelica sinensis and 5 to 15 parts by weight of white Radix Ginseng. The medicine for treating toothache according to the present invention has different ingredients in comparison with the prior art drugs, and can overcome the disadvantages of the prior art drugs.

Description

MEDICINE FOR TREATING TOOTH SICKNESS AND METHOD FOR PREPARING THE SAME

Technical area

The present invention relates to the field of medicaments, in particular a medicament for treating toothache and its method of preparation.

Background

Toothache is mainly caused by infections of the dental pulp (nerves of the teeth) due to gingivitis and periodontitis, decayed teeth (dental caries) or broken teeth. Specifically, the toothache is due to the following reasons: lack of attention to oral hygiene; long-term irritation of teeth by soft tartar and hard tartar formed by food residues around the teeth, bacteria, etc. ;

bad brushing habits;

and vitamin deficiency.

Toothache is a common symptom of many types of dental disease and periodontal disease, and is characterized by toothache as the main clinical manifestation, accompanied by symptoms of swollen gums, dysmasesis or toothache intermittent, pain from cold and hot irritation, swollen cheeks, etc.

The reasons causing toothache are classified according to the following types cold-wind attack

Treatment for this toothache: chasing the wind and eliminating the cold, warming the canals to relieve the pain

2) hot-wind attack

Treatment for this toothache: chase the wind and dissipate the heat to relieve the pain

3) plenty of stomach fire

Treatment for this toothache: clear the stomach and purge intense heat, relieve swelling and pain

4) reviving a weakened fire ("ashtenic fire")

Treatment for this toothache: enrich the Ying and nourish the kidneys, purge intense heat to relieve pain.

However, as with any type of toothache, relying on the treating effect of the above treatment is not ideal, with only one therapeutic effect. In addition, current drugs have different toxicities and different side effects. There is therefore an urgent need for a new medicine to treat toothache in order to overcome the above drawbacks.

Summary of the invention

In view of the above problem, the present invention provides a medicament for treating toothache, capable of solving the above problems or at least some of the above problems, used to overcome the disadvantages of the poor effects dealing with prior art drugs.

According to a first aspect, the present invention provides a medicament for treating toothache, comprising from 15 to 25 parts by weight of Fructus forsythiae, from 10 to 25 parts by weight of Lonicera japonica, from 13 to 20 parts by weight of Radix Paeoniae Rubra, from 12 to 20 parts by weight of Angelica sinensis and from 5 to 15 parts by weight of white Radix Ginseng.

The present invention discloses a medicament for treating toothache and its method of preparation. The medicament for treating toothache according to the present invention has different ingredients in comparison with the medicaments of the prior art, and can overcome the disadvantages of the medicaments of the prior art.

Detailed description of the embodiments

In one embodiment of the present invention there is provided a medicament for treating toothache comprising from 15 to 25 parts by weight of Fructus forsythiae, from 10 to 25 parts by weight of Lonicera japonica, from 13 to 20 parts by weight of Radix Paeoniae Rubra, from 12 to 20 parts by weight of Angelica sinensis and from 5 to 15 parts by weight of Radix Ginseng white.

In addition, the medicament may additionally comprise from 20 to 30 parts by weight of Fructus Amomi.

In addition, the medicament may additionally comprise from 12 to 18 parts by weight of Radix Paeoniae Rubra.

The Fructus Amomi and Radix Paeoniae Rubra above are only some specific examples, which are not intended to be limiting, and other materials such as lycet berry, Gynostemma pentaphyllum, 12 Semen Astragali Complanati, Radix Dipsaci, Herba Eclipta,

Fructus Ligustri Lucidi, etc. are also possible.

Other possible materials will not be described in detail.

Optionally in one embodiment of the present invention, materials to reinvigorate the blood circulation such as Carcuma longua, Ligusticum chuanxiong Hort, Radix

Salviae Miltiorrhizae and / or evening primrose can be added.

In addition, in one embodiment of the present invention, in order to improve the pharmacological effect, the medicament may further comprise materials for removing heat, such as Fructus Gardeniae, Flos Chrysanthemi, Semen Cassiae, Cortex fraxini, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici and / or Lonicera japonica, etc.

In addition, the drug may further include materials for wicking moisture and promoting diuresis, such as Herba Sedi, Abrus herb, etc.

In addition, the drug may further include materials for warming the interior, such as chilli.

In one embodiment of the present invention, the dosage form of the drug is at least one of the forms selected from a film-coated tablet, a coated tablet, an enteric-coated tablet, a dispersible tablet, a capsule, a granule, a decoction, a mixture, a syrup, a wine, an injectable composition, a solution for oral use and a cloudy liquid for oral use.

In one embodiment of the present invention, the medicament optionally has a dosage form for oral administration.

In one embodiment of the present invention, the dosage form for oral administration optionally includes a tablet, capsule, pill, sustained release preparation, and controlled release preparation.

The medicament of the embodiment provided in the present invention or the medicament composition comprising it can be administered in unit dosage form through the intestinal tract, nasal cavity, oral mucosa, eyes, lungs, respiratory tract, skin, rectum, etc., and can be administered by oral administration, intravenous injection, intramuscular injection and subcutaneous injection.

The dosage form of administration may be a liquid dosage form, a solid dosage form or a semi-solid dosage form. The liquid dosage form may be a solution, an emulsion, a suspension, an injectable composition (including an aqueous injectable composition, a powder injectable composition and a composition for infusion), eye drops, nose drops, a lotion and a liniment; the solid dosage form may be a tablet (including an uncoated tablet, an enteric-coated tablet, an oral tablet, a dispersible tablet, a chewable tablet, an effervescent tablet, a disintegrating tablet in the oral cavity) , a capsule (including a hard capsule, a soft capsule, an enteric capsule), a granule, a powder, a lozenge, a swallowing pill, a suppository, a film agent, a plaster, an aerosol, a spray, etc. . ; and the semi-solid dosage form can be an ointment, a gel, a paste, etc. The dosage form of the drug is preferably a tablet, a capsule, a pill, and an injectable composition.

The medicament in accordance with an embodiment of the present invention can be prepared as a conventional preparation, a sustained release preparation, a controlled release preparation, a targeted preparation, and various preparations to be administered in granules.

so under

In one mode of preparing the excipient form such disintegrating agent,

The diluent can be glucose, the drug makes a diluent, a lubricant, be starch, lactose, the present invention, the present invention can use various binder, a humectant, a slip agent.

dextrin, sucrose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like; The humectant can be water, ethanol, isopropanol and their analogs; the binder can be starch pulp, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic pulp, gelatin pulp, sodium carboxymethylcellulose and methylcellulose; the disintegrating agent can be dry starch, microcrystalline cellulose, weakly substituted hydroxypropylcellulose; and the lubricant and the slip agent can be talc, silica, a stearate, liquid paraffin and their analogs.

In addition, the medicament may also be a coated tablet, for example a coated tablet, a film-coated tablet, an enteric-coated tablet, and the like.

When the drug is prepared in the form of a capsule, the active ingredient can be prepared in granules or lozenges with the addition of diluent, binder and disintegrating agent, which are then placed in a hard capsule or capsule. soft.

When the medicament is prepared in the form of an injectable composition, the solvent can be composed of water, ethanol, isopropanol, propylene glycol, or a mixture of these. In addition, an appropriate amount of solubilizing agent, co-solvent, pH adjusting agent, osmotic pressure adjusting agent, can be added.

In addition, the medicament can be added with a colorant, a preservative, a perfume, a corrector or other additives.

In one embodiment of the present invention, there is provided a process for preparing the above medicament, comprising the following steps:

first step: weighing from 15 to 25 parts by weight of Fructus forsythiae, from 10 to 25 parts by weight of Lonicera japonica, from 13 to 20 parts by weight of Radix Paeoniae Rubra, from 12 to 20 parts by weight of Angelica sinensis and 5 to 15 parts by weight of white Radix Ginseng;

second step: mixing the raw materials above so that a mixture is obtained, spraying the mixture, and sieving with, for example, a 100 mesh sieve;

third step: adding water to the sieved raw materials, and soaking for 6-8 hours;

fourth step: heating the quenched raw materials, preferably for 40 minutes; and fifth step: filtration to remove deposits to obtain a leachate which is the targeted drug.

Several specific examples of the process for preparing the medicament for the treatment of toothache are provided below.

Example 1

First stage: weighing from 15 to 25 parts by weight of Fructus forsythiae, from 10 to 25 parts by weight of Lonicera japonica, from 13 to 20 parts by weight of Radix Paeoniae Rubra, from 12 to 20 parts by weight of Angelica sinensis and 5 to 15 parts by weight of white Radix Ginseng;

second step: mixing the raw materials above so that a mixture is obtained, spraying the mixture, and sieving with a 100 mesh sieve;

third stage: addition of water to the sieved raw materials, and soaking for 6 hours;

fourth step: heating the quenched raw materials for 40 minutes with the addition of 10 ml of water every 20 minutes; and fifth step: filtration to remove deposits to obtain a leachate which is the targeted drug.

Example 2

First stage: weighing 15 parts by weight of Fructus forsythiae, 10 parts by weight of Lonicera japonica, 13 parts by weight of Radix Paeoniae Rubra, 18 parts by weight of Angelica sinensis, 20 parts by weight of Fructus amomi and 12 parts by weight of white Radix Ginseng;

second step: spraying the above raw materials into a powder, sieving the powder with a 100 mesh sieve, and uniform mixing so that a fine powder is obtained;

third step: soaking the above fine powder with water for at least 8 hours until completely soaked;

fourth step: decoction of the resulting quenched product twice, each time for 40 minutes at 30 ° C, and filtration so that two filtrates are obtained;

fifth step: mixing of the two filtrates, standing at room temperature for 30 minutes so that a supernatant is obtained, and concentration under vacuum of the supernatant so that a thick paste is obtained; and sixth step: drying the thick paste and spraying it, and uniformly mixing the resulting pulverized product with the above fine powder and an adjuvant material in an appropriate proportion, so that the targeted medicament is obtained.

Example 3

First stage: weighing 25 parts by weight of Fructus forsythiae, 10 parts by weight of Lonicera japonica, 18 parts by weight of Radix Paeoniae Rubra, 18 parts by weight of Angelica sinensis, 30 parts by weight of Fructus amomi , 15 parts by weight of Rhizoma Smilacis Glabrae and 12 parts by weight of Radix

White ginseng;

second step: spraying the above raw materials into a powder, sieving the powder with a 100 mesh sieve, and uniform mixing so that a fine powder is obtained;

third step: soaking the above fine powder with water for at least 8 hours until completely soaked;

fourth step: heating the resulting quenched product at 30 ° C for 40 minutes, filtration to obtain a filtrate;

fifth step: resting the filtrate at room temperature for 30 minutes so that a supernatant is obtained, and concentrating the supernatant under vacuum so that a thick paste is obtained; and sixth step: drying the thick paste and spraying it, and uniformly mixing the resulting pulverized product with the above fine powder and an adjuvant material in an appropriate proportion, so that the intended medicament is obtained.

Example 4

First stage: weighing 25 parts by weight of Fructus forsythiae, 10 parts by weight of Lonicera japonica, 18 parts by weight of Radix Paeoniae Rubra, 18 parts by weight of Angelica sinensis, 30 parts by weight of Fructus amomi , 15 parts by weight of Rhizoma Smilacis Glabrae and 12 parts by weight of Radix Ginseng white;

second step: spraying the above raw materials into a powder, sieving the powder with a 100 mesh sieve, and uniform mixing so that a fine powder is obtained;

third step: soaking the above fine powder with water for at least 8 hours until fully soaking;

fourth step: decoction of the resulting soaked product over low heat and further decoction for 30 minutes after boiling, three times, so that three decoction solutions are obtained, and mixing of the three decoction solutions so that a decoction is obtained.

The medicament for treating toothache according to the present invention has different ingredients in comparison with the medicaments of the prior art, and can overcome the disadvantages of the medicaments of the prior art.

Claims (5)

1. Medicine for treat the evil of teeth comprising of 15 to 25 parties in weight of Fructus Forsythiae, of 10 to 25 parties in weight of Lonicera japonica, from 13 to 20 parts by weight of Radix Paeoniae Rubra, from 12 to 20 parts by weight of Angelica sinensis and from 5 to 15 parts by weight of White Radix Ginseng. 2. A medicine for treating toothache according to claim 1, further comprising 20 to 30 parts by weight of Fructus amomi. 3. Medicine for treating toothache according to claim 1, further comprising from 12 to 18 parts in weight by Radix Paeoniae Rubra. 4. Medicine to treat the wrong teeth according 1 'a any of claims 1 at 3 , in which the form dosage of drug is at less One of forms chosen from a film-coated tablet, a coated tablet, an enteric-coated tablet, a dispersible tablet, a capsule, a granule, a decoction, a mixture, a syrup, a wine, an injectable composition, a solution for oral use and a cloudy liquid for oral use. 5. Method for preparing the medicament according to any one of claims 1 to 4, comprising the following steps: first step: weighing from 15 to 25 parts by weight of Fructus forsythiae, from 10 to 25 parts by weight of Lonicera japonica, from 13 to 20 parts by weight of Radix Paeoniae Rubra, from 12 to 20 parts by weight of Angelica sinensis and 5 to 15 parts by weight of white Radix Ginseng; second step: mixing the above raw materials so that a mixture is obtained, spraying the mixture, and sieving with, for example, a 100 mesh sieve; third step: adding water to the sieved raw materials, and soaking for 6 to 8 hours; Fourth step: heating the quenched raw materials, preferably for 40 minutes; and fifth step: filtration to remove deposits to obtain a leachate which is the targeted drug.