CN103222947B - Traditional Chinese medicinal composition for treating periodontitis - Google Patents
Traditional Chinese medicinal composition for treating periodontitis Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicinal composition for treating the periodontitis. The composition comprises the following raw materials, by weight, 200-800 parts of halite, 150-600 parts of a Tortoiseshell extract, 50-300 parts of a Ligusticum wallichii extract, 50-200 parts of a Rhizoma Cyperi extract, 50-200 parts of a Chinese prickly ash extract, 50-200 parts of a Shrubalthea Bark extract, 30-150 parts of a dahurian angelica root extract, 30-150 parts of a Cyrtomium fortune extract, 30-150 parts of a Bletilla striata extract, 10-50 parts of a mint extract, 20-60 parts of a Natural Indigo extract and 3-18 parts of a Syzygium aromaticum extract. The traditional Chinese medicinal composition has substantial medicine medicines, can shorten the treatment period of the periodontitis, and can realize the fast heal of periodontitis patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of periodontitis.
Background technology
Periodontitis is that periodontal support is organized to gingiva, periodontal membrane, alveolar bone and cemental chronically infected disease, often causes the inflammatory destruction of periodontal support tissue.The main clinical manifestation of periodontitis is that gingivitis, hemorrhage, periodontal pocket formation, frontal resorption, phatnoma bone height reduce, odontoseisis displacement, masticatory atonia, and severe patient tooth can self falling or caused pulling out of tooth.
Chinese patent literature CN1170580 discloses a kind of Chinese medicine composition for the treatment of periodontitis, and its prescription comprises Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis, the Radix Angelicae Dahuricae, Pericarpium Zanthoxyli, Cortex Hibisci, halite.Each Chinese medicinal components is made as powder through processing, when use, is applied in gingiva place after tempering.The Chinese medicine composition of above-mentioned treatment periodontitis has certain therapeutical effect to periodontitis, but, have the following disadvantages: the Chinese medicine composition that 1) adopts the disclosed prescription of above-mentioned document and proportioning to obtain, the curative effect for the treatment of periodontitis is comparatively slow, and patient needs the continuous use long period to fully recover; 2) because periodontitis is to be caused by the bacterial plaque microorganism and the product thereof that are deposited in facing and the gingival sulcus of dentogingival junction, the bacterial plaque that is piled up in facing and gingival sulcus is conducive to growing of some Grain-negative Periodontal Pathogens of under anaerobic growing, and then form pathogenic very strong biomembrane, every factor that can increase the weight of bacterial plaque delay, the local promoting factor that all can become periodontal disease, increases the weight of and accelerates the progress of periodontitis.Therefore, above-mentioned using method, in alleviating the periodontitis state of an illness, cannot be cleared up intraoral microorganism, is unfavorable for that patient comparatively fast fully recovers; 3) be applied in gingiva place poor to patient's adaptability, and its using method is comparatively loaded down with trivial details, is prone to patient because improvement drug withdrawal makes Relapse rate, causes curative effect unstable.
Summary of the invention
It is slower that technical problem to be solved by this invention is to treat in prior art the Chinese medicine composition curative effect of periodontitis, and then provide one to treat periodontitis instant effect Chinese medicine composition.
Second technical problem to be solved by this invention is that the very fast recovery from illness of patient be cleared up, be unfavorable for to the Chinese medicine composition for the treatment of periodontitis in prior art cannot and its using method is comparatively loaded down with trivial details, easily make Relapse rate to intraoral microorganism, and then a kind of Chinese medicinal toothpaste and Chinese medicine mouth wash of the treatment periodontitis of clearing up oral hygiene, easy to use, stable curative effect are provided.
The present invention also further provides the preparation method of above-mentioned Chinese medicinal toothpaste and Chinese medicine mouth wash.
For this reason, the invention provides a kind of Chinese medicine composition for the treatment of periodontitis, comprise the raw material of following weight portion: halite 200-800 part, Carapax Et Plastrum Testudinis extract 150-600 part, Rhizoma Chuanxiong extract 50-300 part, Rhizoma Cyperi extract 50-200 part, Fructus Zanthoxyli extract 50-200 part, Cortex Hibisci extract 50-200 part, Radix Angelicae Dahuricae extract 30-150 part, Rhizoma Osmundae extract 30-150 part, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 30-150 part, Folium Menthae extract 10-50 part, Indigo Naturalis extract 20-60 part, Flos Caryophylli extract 3-18 part.
Further preferred, the Chinese medicine composition of described treatment periodontitis, comprises the raw material of following weight portion: halite 250-350 part, Carapax Et Plastrum Testudinis extract 150-250 part, Rhizoma Chuanxiong extract 50-200 part, Rhizoma Cyperi extract 50-100 part, Fructus Zanthoxyli extract 50-100 part, Cortex Hibisci extract 50-100 part, Radix Angelicae Dahuricae extract 30-80 part, Rhizoma Osmundae extract 30-80 part, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 30-80 part, Folium Menthae extract 10-30 part, Indigo Naturalis extract 20-40 part, Flos Caryophylli extract 6-12 part.
Most preferred, the Chinese medicine composition of described treatment periodontitis, comprises the raw material of following weight portion: 300 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 100 parts of Rhizoma Chuanxiong extracts, 80 parts of Rhizoma Cyperi extracts, 80 parts of Fructus Zanthoxyli extracts, 80 parts of Cortex Hibisci extracts, 50 parts of Radix Angelicae Dahuricae extracts, 50 parts of Rhizoma Osmundae extracts, 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 8 parts of Flos Caryophylli extracts.
The Chinese medicine composition of described treatment periodontitis adds in toothpaste, makes Chinese medicinal toothpaste.In described Chinese medicinal toothpaste, the content of described Chinese medicine composition is 0.1-5wt%.Further, in described Chinese medicinal toothpaste, the content of described Chinese medicine composition is 1wt%.
The Chinese medicine composition of described treatment periodontitis adds in collutory, makes Chinese medicine mouth wash.In described Chinese medicine mouth wash, the content of described Chinese medicine composition is 0.1-5wt%.Further, in described Chinese medicine mouth wash, the content of described Chinese medicine composition is 1wt%.
The preparation method that the invention still further relates to a kind of Chinese medicinal toothpaste for the treatment of periodontitis, comprises the following steps:
(1) preparation of Chinese medicine extract: be the ethanol of 70-75% to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep 50-80 DEG C of reflux, extract, of temperature, filter, alcohol extract retains for subsequent use, add again deionized water, keep 50-80 DEG C of reflux, extract, of temperature, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 200-250nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 200-250nm;
(3) prepare toothpaste: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, add in toothpaste matrix, the final vacuum that stirs is degassed, obtains Chinese medicinal toothpaste.
Wherein, described toothpaste matrix comprises following raw material: wetting agent, abrasivus, binding agent, surfactant, deionized water, sweeting agent, antiseptic, essence.
Described wetting agent is one or more in sorbitol, Polyethylene Glycol, glycerol; Described abrasivus is hydration Silicon stone; Described surfactant is lauryl alcohol sulfuric acid ester sodium; Described binding agent is one or more in Chondrus crispus, cellulose gum; Described antiseptic is sodium benzoate.
Further, the preparation method of described Chinese medicinal toothpaste, comprises the following steps:
(1) preparation of Chinese medicine extract: be the ethanol of 70-75% to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep 50-80 DEG C of reflux, extract, of temperature, filter, alcohol extract retains for subsequent use, add again deionized water, keep 50-80 DEG C of reflux, extract, of temperature, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 200-250nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 200-250nm;
(3) prepare toothpaste: take by weight Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, the extract of Indigo Naturalis and halite and described wetting agent, described antiseptic, the described sweeting agent that step (2) obtains that step (1) obtains and be jointly dissolved in deionized water, be uniformly dissolved, obtain mixed liquor; By described abrasivus, described binding agent, described surfactant mix homogeneously, obtain solid mixture; Above-mentioned mixed liquor is mixed homogeneously with solid mixture, then add described essence, described Flos Caryophylli extract, the final vacuum that stirs is degassed, obtains Chinese medicinal toothpaste.
The preparation method that the invention still further relates to a kind of Chinese medicine mouth wash for the treatment of periodontitis, comprises the following steps:
(1) preparation of Chinese medicine extract: be the ethanol of 70-75% to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep 50-80 DEG C of reflux, extract, of temperature, filter, alcohol extract retains for subsequent use, add again deionized water, keep 50-80 DEG C of reflux, extract, of temperature, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 200-250nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 200-250nm;
(3) prepare collutory: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, add in collutory, after stirring, obtain Chinese medicine mouth wash.
The traditional Chinese medical science thinks that periodontitis belongs to " gingival atrophy ", " toothache " category, and its pathogenesis is the flourishing or hyperactivity of deficient fire of pathogenic fire.Treatment by Chinese herbs primary disease is with clearing stomach pathogenic fire reducing, removing toxic substances and promoting subsidence of swelling, and cooling blood for hemostasis, disperse blood stasis and dredge collateral, enriching yin and nourishing kidney are the rule for the treatment of.
The selected halite of Chinese medicine composition raw material of the present invention, salty in the mouth, cold in nature, nontoxic, enter the heart, kidney, liver, lung, urinary bladder channel, have purge heat, removing heat from blood, improving eyesight, the effect of moisturizing; Carapax Et Plastrum Testudinis, salty in the mouth, sweet, cold nature, returns liver, kidney, heart channel, has nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, effect of the reinforcing the heart of nourishing blood; Rhizoma Chuanxiong, acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, there is blood-activating and qi-promoting, the effect of wind-expelling pain-stopping; Rhizoma Cyperi, bitter but sweet flavor, property is flat, enters liver, tri-jiao channel, has the effect of the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving; Pericarpium Zanthoxyli, acrid in the mouth, warm in nature, return spleen, stomach, kidney channel, there is warming middle-JIAO to relieve pain, effect of killing parasites for relieving itching; Cortex Hibisci, sweet in the mouth, hardship, cold nature, has clearing away heat-damp and promoting diuresis, the effect of killing parasites for relieving itching; The Radix Angelicae Dahuricae, acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is expelling wind and cold, understand things pain-stopping, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, the effect of dampness leukorrhagia stopping; Rhizoma Osmundae, acrid in the mouth, hardship, cold in nature, enter lung meridian, there is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of parasite killing; The Pseudobulbus Bletillae (Rhizoma Bletillae), bitter in the mouth, sweet, puckery, cold nature, returns lung, liver, stomach warp, has astringing to arrest bleeding, the effect of detumescence and promoting granulation; Herba Menthae, acrid in the mouth, cold in nature, has dispelling wind and heat pathogens, effect of the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting; Indigo Naturalis, salty in the mouth cold in nature, returns Liver Channel, has heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, the effect of pathogenic fire purging arresting convulsion; Flos Caryophylli, sweet in the mouth, pungent, extremely hot in nature, enters stomach kidney two warps, can control cold syndrome of the stomach pain with distension, singultus, vomiting and diarrhoea, arthralgia pain, colic, halitosis, toothache.After said medicine compatibility, play altogether clearing stomach pathogenic fire reducing, removing toxic substances and promoting subsidence of swelling, cooling blood for hemostasis, disperse blood stasis and dredge collateral, effect of enriching yin and nourishing kidney, has the effect for the treatment of both the principal and secondary aspects of a disease to periodontitis.Test shows that traditional Chinese medicine composition for treating periodontitis of the present invention can be eliminated periodontal tissue's local inflammation effectively, make gums swelling pain and simultaneous phenomenon be alleviated, disappear, reach strengthening vital QI to eliminate pathogenic factors, heat-clearing and toxin-vanquishing, evacuation of pus detumescence, hemostasis teeth consolidating, the object of deodorization analgesic therapy.
The Chinese medicine composition for the treatment of periodontitis of the present invention has the following advantages:
(1) Chinese medicine composition for the treatment of periodontitis of the present invention, comprises halite, Carapax Et Plastrum Testudinis extract, Rhizoma Chuanxiong extract, Rhizoma Cyperi extract, Fructus Zanthoxyli extract, Cortex Hibisci extract, Radix Angelicae Dahuricae extract, Rhizoma Osmundae extract, Pseudobulbus Bletillae (Rhizoma Bletillae) extract, Folium Menthae extract, Indigo Naturalis extract, Flos Caryophylli extract.In above-mentioned Chinese medicine ingredients, halite, Cortex Hibisci, Rhizoma Osmundae, Indigo Naturalis, Herba Menthae all have the effect of purging heat, moisturizing, and Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, the Radix Angelicae Dahuricae, the Pseudobulbus Bletillae (Rhizoma Bletillae) all have the evacuation of pus of invigorating blood circulation, alleviate the effect of toothache.Carapax Et Plastrum Testudinis, in the process for the treatment of periodontitis, can play the effect of enriching yin and nourishing kidney, acts on bone marrow by the approach of the kidney invigorating, and induction bone marrow stem cell enriches alveolar bone place, eliminates periodontal disease, firm tooth.Flos Caryophylli extract wherein, the effect of not only can play promoting blood circulation and stopping pain, removing halitosis, also can play the active effect of anti-bacteria by the permeability of the cell membrane of destruction antibacterial, change bacterial cell membrane.Experiment shows, said components can cooperatively interact in the time for the treatment of periodontitis, produces good drug effect, pain relieving faster, reduces times of bleeding, reduces periodontal pocket, the kidney invigorating teeth consolidating.In the time of application traditional Chinese medicine composition for treating periodontitis of the present invention, because periodontitis causes because of microorganism and product thereof, the interpolation of Flos Caryophylli extract has suppressed to cause the activity of periodontitis microorganism and product thereof, with other removing heat from blood moisturize, invigorate blood circulation evacuation of pus component produce synergism, can promote the quick recovery from illness of periodontitis.And the kidney invigorating bone strengthening effect of Carapax Et Plastrum Testudinis can be to promoting the bone marrow stem cell in patients with periodontitis body to enrich alveolar bone place, play the effect of good teeth consolidating and elimination periodontal disease.Above-mentioned multiple-effect combined effect ensures that the content of each component, in scope disclosed by the invention, can significantly strengthen drug effect simultaneously, shortens the treatment cycle of periodontitis.
(2) Chinese medicine composition for the treatment of periodontitis of the present invention, adds in toothpaste, makes Chinese medicinal toothpaste.Toothpaste is with respect to other pharmaceutical dosage form, first, can utilize the abrasivus of toothpaste to remove the bacterial plaque that is piled up in facing and gingival sulcus, oral cavity is cleaned, better reach the effect for the treatment of periodontitis, match with the effective ingredient of Chinese medicine composition, can significantly alleviate the formation of tartar, dental plaque, and can play certain dental prophylaxis effect.The second, while treating periodontitis by mode oral or that smear, be easy to occur that patient is because transferring well the Relapse rate that drug withdrawal causes.And using toothpaste treatment periodontitis stronger to patient's adaptability, the process of brushing teeth in daily life can realize the treatment to periodontitis.
(3) Chinese medicine composition for the treatment of periodontitis of the present invention, adds in collutory, makes Chinese medicine mouth wash.Described Chinese medicine composition is made to collutory, can facilitate the use of patients with periodontitis, convenient use at any time, and be easy to carry.
(4) Chinese medicinal toothpaste for the treatment of periodontitis of the present invention or the preparation method of Chinese medicine mouth wash, adopting the method for micro-nano processing that raw material of Chinese medicine is made as to nano-scale particle adds in toothpaste, collutory, the bioavailability of described Chinese medicine composition can be improved, in the time that patient uses, good absorption can be kept.Meanwhile, also can better ensure that the Chinese medicinal toothpaste, the Chinese medicine mouth wash drug effect that obtain can keep homogeneity for a long time, there will not be along with passage of time the phenomenons such as Chinese medicinal ingredients precipitation.
Detailed description of the invention
Embodiment 1
The Chinese medicine composition of the treatment periodontitis of the present embodiment adopts the raw material of following weight portion to make: 200 parts of halites, 375 parts of Carapax Et Plastrum Testudinis extracts, 300 parts of Rhizoma Chuanxiong extracts, 50 parts of Rhizoma Cyperi extracts, 125 parts of Fructus Zanthoxyli extracts, 200 parts of Cortex Hibisci extracts, 30 parts of Radix Angelicae Dahuricae extracts, 90 parts of Rhizoma Osmundae extracts, 150 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 10 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 18 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 70% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep 80 DEG C of reflux, extract, 1h of temperature, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 50 C reflux, extract, 1h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 200nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 200nm;
(3) take by weight the extract of Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, mix homogeneously, obtains the Chinese medicine composition of the present embodiment.
Embodiment 2
The Chinese medicine composition of the treatment periodontitis of the present embodiment adopts the raw material of following weight portion to make: 800 parts of halites, 150 parts of Carapax Et Plastrum Testudinis extracts, 50 parts of Rhizoma Chuanxiong extracts, 200 parts of Rhizoma Cyperi extracts, 50 parts of Fructus Zanthoxyli extracts, 125 parts of Cortex Hibisci extracts, 90 parts of Radix Angelicae Dahuricae extracts, 30 parts of Rhizoma Osmundae extracts, 90 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 50 parts of Folium Menthae extracts, 20 parts of Indigo Naturalis extracts, 3 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 75% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 50 C reflux, extract, 2h, filter, alcohol extract retains for subsequent use, add again deionized water, keep 80 DEG C of reflux, extract, 2h of temperature, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 250nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 250nm;
(3) take by weight the extract of Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, mix homogeneously, obtains the Chinese medicine composition of the present embodiment.
Embodiment 3
The Chinese medicine composition of the treatment periodontitis of the present embodiment adopts the raw material of following weight portion to make: 500 parts of halites, 600 parts of Carapax Et Plastrum Testudinis extracts, 175 parts of Rhizoma Chuanxiong extracts, 125 parts of Rhizoma Cyperi extracts, 200 parts of Fructus Zanthoxyli extracts, 50 parts of Cortex Hibisci extracts, 150 parts of Radix Angelicae Dahuricae extracts, 150 parts of Rhizoma Osmundae extracts, 30 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 30 parts of Folium Menthae extracts, 60 parts of Indigo Naturalis extracts, 10.5 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 72% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep 65 DEG C of reflux, extract, 3h of temperature, filter, alcohol extract retains for subsequent use, add again deionized water, keep 65 DEG C of reflux, extract, 3h of temperature, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 225nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 225nm;
(3) take by weight the extract of Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, mix homogeneously, obtains the Chinese medicine composition of the present embodiment.
Embodiment 4
The Chinese medicine composition of the treatment periodontitis of the present embodiment adopts the raw material of following weight portion to make: 250 parts of halites, 250 parts of Carapax Et Plastrum Testudinis extracts, 125 parts of Rhizoma Chuanxiong extracts, 100 parts of Rhizoma Cyperi extracts, 75 parts of Fructus Zanthoxyli extracts, 100 parts of Cortex Hibisci extracts, 80 parts of Radix Angelicae Dahuricae extracts, 55 parts of Rhizoma Osmundae extracts, 80 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 30 parts of Indigo Naturalis extracts, 6 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 3h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 1h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) take by weight the extract of Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, mix homogeneously, obtains the Chinese medicine composition of the present embodiment.
Embodiment 5
The Chinese medicine composition of the treatment periodontitis of the present embodiment adopts the raw material of following weight portion to make: 350 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 200 parts of Rhizoma Chuanxiong extracts, 75 parts of Rhizoma Cyperi extracts, 50 parts of Fructus Zanthoxyli extracts, 50 parts of Cortex Hibisci extracts, 30 parts of Radix Angelicae Dahuricae extracts, 80 parts of Rhizoma Osmundae extracts, 55 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 10 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 12 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 4h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 2h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) take by weight the extract of Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, mix homogeneously, obtains the Chinese medicine composition of the present embodiment.
Embodiment 6
The Chinese medicine composition of the treatment periodontitis of the present embodiment adopts the raw material of following weight portion to make: 300 parts of halites, 150 parts of Carapax Et Plastrum Testudinis extracts, 50 parts of Rhizoma Chuanxiong extracts, 50 parts of Rhizoma Cyperi extracts, 100 parts of Fructus Zanthoxyli extracts, 75 parts of Cortex Hibisci extracts, 55 parts of Radix Angelicae Dahuricae extracts, 30 parts of Rhizoma Osmundae extracts, 30 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 30 parts of Folium Menthae extracts, 20 parts of Indigo Naturalis extracts, 9 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 2h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 3h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) take by weight the extract of Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, mix homogeneously, obtains the Chinese medicine composition of the present embodiment.
Embodiment 7
The Chinese medicine composition of the treatment periodontitis of the present embodiment adopts the raw material of following weight portion to make: 300 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 100 parts of Rhizoma Chuanxiong extracts, 80 parts of Rhizoma Cyperi extracts, 80 parts of Fructus Zanthoxyli extracts, 80 parts of Cortex Hibisci extracts, 50 parts of Radix Angelicae Dahuricae extracts, 50 parts of Rhizoma Osmundae extracts, 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 8 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 4h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 1h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) take by weight the extract of Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, mix homogeneously, obtains the Chinese medicine composition of the present embodiment.
Embodiment 8
The Chinese medicinal toothpaste of the treatment periodontitis of the present embodiment, wherein, Chinese medicine composition adopts the raw material of following weight portion to make: 300 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 100 parts of Rhizoma Chuanxiong extracts, 80 parts of Rhizoma Cyperi extracts, 80 parts of Fructus Zanthoxyli extracts, 80 parts of Cortex Hibisci extracts, 50 parts of Radix Angelicae Dahuricae extracts, 50 parts of Rhizoma Osmundae extracts, 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 8 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 5h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 3h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) prepare toothpaste: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, content according to described Chinese medicine composition in described Chinese medicinal toothpaste is the addition of 0.1wt%, adds in toothpaste matrix.The final vacuum that stirs is degassed, obtains Chinese medicinal toothpaste.
Embodiment 9
The Chinese medicine mouth wash of the treatment periodontitis of the present embodiment, wherein, Chinese medicine composition adopts the raw material of following weight portion to make: 300 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 100 parts of Rhizoma Chuanxiong extracts, 80 parts of Rhizoma Cyperi extracts, 80 parts of Fructus Zanthoxyli extracts, 80 parts of Cortex Hibisci extracts, 50 parts of Radix Angelicae Dahuricae extracts, 50 parts of Rhizoma Osmundae extracts, 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 8 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 2h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 5h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) prepare collutory: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, content according to described Chinese medicine composition in Chinese medicine mouth wash is the addition of 5wt%, adds in collutory.After stirring, obtain Chinese medicine mouth wash.
Embodiment 10
The Chinese medicinal toothpaste of the treatment periodontitis of the present embodiment, wherein, Chinese medicine composition adopts the raw material of following weight portion to make: 300 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 100 parts of Rhizoma Chuanxiong extracts, 80 parts of Rhizoma Cyperi extracts, 80 parts of Fructus Zanthoxyli extracts, 80 parts of Cortex Hibisci extracts, 50 parts of Radix Angelicae Dahuricae extracts, 50 parts of Rhizoma Osmundae extracts, 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 8 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 3h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 4h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) prepare toothpaste: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, the halite that step (2) obtains, content according to described Chinese medicine composition in Chinese medicinal toothpaste is the addition of 2.55wt%, adds in toothpaste matrix.The final vacuum that stirs is degassed, obtains Chinese medicinal toothpaste.
Embodiment 11
The Chinese medicinal toothpaste of the treatment periodontitis of the present embodiment, wherein, Chinese medicine composition adopts the raw material of following weight portion to make: 300 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 100 parts of Rhizoma Chuanxiong extracts, 80 parts of Rhizoma Cyperi extracts, 80 parts of Fructus Zanthoxyli extracts, 80 parts of Cortex Hibisci extracts, 50 parts of Radix Angelicae Dahuricae extracts, 50 parts of Rhizoma Osmundae extracts, 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 8 parts of Flos Caryophylli extracts.
Its preparation method is:
(1) preparation of Chinese medicine extract: be 73% ethanol to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep temperature 70 C reflux, extract, 4h, filter, alcohol extract retains for subsequent use, add again deionized water, keep temperature 70 C reflux, extract, 1h, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 230nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 230nm;
(3) prepare toothpaste: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, the halite that step (2) obtains, content according to described Chinese medicine composition in Chinese medicinal toothpaste is the addition of 1wt%, adds in toothpaste matrix.The final vacuum that stirs is degassed, obtains Chinese medicinal toothpaste.
In above embodiment, Flos Caryophylli extract used is Ji'an City state light perfumery, Jiangxi Province, produces the natural quality Oleum Caryophylli (containing eugenol more than 85%) that is numbered 4191540016.In addition, the Flos Caryophylli extract described in the application can adopt any commercially available Flos Caryophylli extract product.
Contrast on effect example
(1) observation index
It is observation index that this Contrast on effect example adopts periodontal disease index:
0 degree: without periodontal pocket, tooth is loosening, tooth X sheet shows that the alveolar bone of tooth absorbs that to be less than or equal to 1/5 root long.
1 degree: 3 millimeters of periodontal pockets, tooth is loosening, and tooth X sheet shows that the alveolar bone of tooth absorbs that to be less than or equal to 1/4 root long.
2 degree: periodontal pocket 3-5 millimeter, tooth has almost can not identify slight loosening, and tooth X sheet shows that the alveolar bone of tooth absorbs that to be less than or equal to 1/3 root long.
3 degree: periodontal pocket 5-7 millimeter, the loosening degree of tooth level is in 1mm, and tooth X sheet shows that the alveolar bone of tooth absorbs that to be less than or equal to 1/3 root long.
4 degree: periodontal pocket 7-10 millimeter, tooth mobility 1mm and more than, and with vertical loosening, tooth X sheet shows that the alveolar bone of tooth absorbs that to be greater than 1/2 root long.
5 degree: periodontal pocket is greater than 10 millimeters, odontoseisis more than 1mm or for floating, drifting tooth. tooth X sheet shows that the alveolar bone of tooth absorbs to the tip of a root.
Choose 6 representative tooth positions 16,11,26,36,31,46 in oral cavity and, as index tooth, substitute with phase adjacent teeth if any disappearance, measure the periodontal disease index of every tooth, and be added summation again divided by 6, obtain average periodontal disease index.
(2) experimental procedure
Patients with periodontitis taking 100 routine periodontal disease indexs as 4 degree is test group 1, test group 2 respectively, and the patients with periodontitis taking 100 routine periodontal disease indexs as 4 degree is as matched group in addition.
Test group 1: the powder that adopts the Chinese medicine composition for the treatment of periodontitis of the present invention to make, every day 2 times, sprays affected part at every turn and keep medicated powder in mouth 15 minutes.
Test group 2: the Chinese medicinal toothpaste that adopts the Chinese medicine composition for the treatment of periodontitis of the present invention to make, according to normal tooth-brushing habit, every day 2-3 time, each rinsing the mouth foam 3 minutes.
Matched group: the powder that adopts Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis, the Radix Angelicae Dahuricae, Pericarpium Zanthoxyli, Cortex Hibisci, halite to make, every day 2 times, sprays affected part at every turn and keep medicated powder in mouth 15 minutes.
The average use of test group 1,2 gets final product pain relieving for 1-2 days, within 4-7 days, significantly reduces times of bleeding, and within 30-40 days, periodontal pocket significantly reduces, and firm tooth, realization in 80-90 days are fully recovered.Matched group on average uses pain relieving in 3-5 days, and within 10-15 days, times of bleeding significantly reduces, and within 60-70 days, periodontal pocket significantly reduces, and the firm tooth in left and right, realization in 150 days are fully recovered.
Patient reaches the required treatment time that periodontal disease index is 0 degree: test group 1 average out to 90 days, test group 2 average out to 80 days, matched group average out to 150 days.
In therapeutic process, matched group has two people can not tolerate medicine taste to exit, have three people because of troublesome poeration finally lost to follow-up; Test group 1 have two people because of troublesome poeration finally lost to follow-up; Test group 2 no ones exit, and represent can continue to use.
(3) conclusion
The Chinese medicine composition for the treatment of periodontitis of the present invention, curative effect is better compared to the medicine of existing treatment periodontitis, has accelerated treatment process, can realize patients with periodontitis and comparatively fast fully recover, and medication is convenient, is easy to be accepted by patient.
Obviously, above-described embodiment is only for example is clearly described, and the not restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here without also giving exhaustive to all embodiments.And the apparent variation of being extended out thus or variation are still within protection scope of the present invention.
Claims (9)
1. a Chinese medicine composition for the treatment of periodontitis, is characterized in that, comprises the raw material of following weight portion:
Halite 200-800 part, Carapax Et Plastrum Testudinis extract 150-600 part, Rhizoma Chuanxiong extract 50-300 part, Rhizoma Cyperi extract 50-200 part, Fructus Zanthoxyli extract 50-200 part, Cortex Hibisci extract 50-200 part, Radix Angelicae Dahuricae extract 30-150 part, Rhizoma Osmundae extract 30-150 part, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 30-150 part, Folium Menthae extract 10-50 part, Indigo Naturalis extract 20-60 part, Flos Caryophylli extract 3-18 part.
2. the Chinese medicine composition for the treatment of periodontitis according to claim 1, is characterized in that, comprises the raw material of following weight portion:
Halite 250-350 part, Carapax Et Plastrum Testudinis extract 150-250 part, Rhizoma Chuanxiong extract 50-200 part, Rhizoma Cyperi extract 50-100 part, Fructus Zanthoxyli extract 50-100 part, Cortex Hibisci extract 50-100 part, Radix Angelicae Dahuricae extract 30-80 part, Rhizoma Osmundae extract 30-80 part, Pseudobulbus Bletillae (Rhizoma Bletillae) extract 30-80 part, Folium Menthae extract 10-30 part, Indigo Naturalis extract 20-40 part, Flos Caryophylli extract 6-12 part.
3. the Chinese medicine composition for the treatment of periodontitis according to claim 2, is characterized in that, comprises the raw material of following weight portion:
300 parts of halites, 200 parts of Carapax Et Plastrum Testudinis extracts, 100 parts of Rhizoma Chuanxiong extracts, 80 parts of Rhizoma Cyperi extracts, 80 parts of Fructus Zanthoxyli extracts, 80 parts of Cortex Hibisci extracts, 50 parts of Radix Angelicae Dahuricae extracts, 50 parts of Rhizoma Osmundae extracts, 50 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) extracts, 20 parts of Folium Menthae extracts, 40 parts of Indigo Naturalis extracts, 8 parts of Flos Caryophylli extracts.
4. a Chinese medicinal toothpaste that adds the treatment periodontitis of the arbitrary described Chinese medicine composition of claim 1-3, is characterized in that: in described Chinese medicinal toothpaste, the content of described Chinese medicine composition is 0.1-5wt%.
5. Chinese medicinal toothpaste according to claim 4, is characterized in that: in described Chinese medicinal toothpaste, the content of described Chinese medicine composition is 1wt%.
6. a Chinese medicine mouth wash that adds the treatment periodontitis of the arbitrary described Chinese medicine composition of claim 1-3, is characterized in that: in described Chinese medicine mouth wash, the content of described Chinese medicine composition is 0.1-5wt%.
7. Chinese medicine mouth wash according to claim 6, is characterized in that: in described Chinese medicine mouth wash, the content of described Chinese medicine composition is 1wt%.
8. according to the preparation method of the Chinese medicinal toothpaste of the treatment periodontitis described in claim 4 or 5, it is characterized in that, comprise the following steps:
(1) preparation of Chinese medicine extract: be the ethanol of 70-75% to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep 50-80 DEG C of reflux, extract, of temperature, filter, alcohol extract retains for subsequent use, add again deionized water, keep 50-80 DEG C of reflux, extract, of temperature, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 200-250nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 200-250nm;
(3) prepare toothpaste: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, add in toothpaste matrix, the final vacuum that stirs is degassed, obtains Chinese medicinal toothpaste.
9. according to the preparation method of the Chinese medicine mouth wash of the treatment periodontitis described in claim 6 or 7, it is characterized in that, comprise the following steps:
(1) preparation of Chinese medicine extract: be the ethanol of 70-75% to adding volume fraction in Carapax Et Plastrum Testudinis, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis respectively, keep 50-80 DEG C of reflux, extract, of temperature, filter, alcohol extract retains for subsequent use, add again deionized water, keep 50-80 DEG C of reflux, extract, of temperature, filter, merge alcohol extract and water extraction liquid, concentrated, the concentrated solution of the each raw material of Chinese medicine obtaining is added in nano-spray drying instrument, obtain the extract powder that diameter of particle is each Chinese medicine of 200-250nm;
(2) processing of halite: halite is dissolved in deionized water, then adds in nano-spray drying instrument, obtaining diameter of particle is the halite powder of 200-250nm;
(3) prepare collutory: the extract that takes by weight Carapax Et Plastrum Testudinis that step (1) obtains, Rhizoma Chuanxiong, Rhizoma Cyperi, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, Rhizoma Osmundae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Menthae, Indigo Naturalis, halite and Flos Caryophylli extract that step (2) obtains, add in collutory, after stirring, obtain Chinese medicine mouth wash.
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| CN104434715A (en) * | 2013-09-24 | 2015-03-25 | 青岛锦涟鑫商贸有限公司 | Traditional Chinese medicine dentifrice capable of caring teeth |
| CN103550123A (en) * | 2013-11-07 | 2014-02-05 | 广西奥奇丽股份有限公司 | Chinese medicinal toothpaste containing pseudo-ginseng total saponins and saponin extracts and tortoise shell extracts |
| CN104547856B (en) * | 2014-12-18 | 2018-02-23 | 苏敏华 | A kind of Chinese medicine composition for treating periodontitis, gel preparation and preparation method thereof |
| CN106880720A (en) * | 2015-12-15 | 2017-06-23 | 夏杰 | A kind of Chinese medicine composition for treating periodontitis |
| CN105616324A (en) * | 2016-01-27 | 2016-06-01 | 珠海迈润实业有限公司 | Mouthwash containing plant formula and preparation method thereof |
| CN105596784A (en) * | 2016-02-17 | 2016-05-25 | 孙茂志 | Traditional Chinese medicine composition for treating periodontitis |
| CN107320389A (en) * | 2017-08-09 | 2017-11-07 | 何家平 | A kind of feverfew children's toothpaste |
| CN109481343A (en) * | 2018-12-22 | 2019-03-19 | 阮朝君 | A kind of edibility rose of Sharon jelly toothpaste and preparation method thereof |
| CN110496165A (en) * | 2019-08-28 | 2019-11-26 | 李艳冰 | A kind of Chinese medicine composition for treating periodontitis |
| CN114983898A (en) * | 2022-07-05 | 2022-09-02 | 贵州苗老藤化妆品生产制造有限公司 | Chinese herbal medicine toothpaste and preparation method thereof |
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