CN102188585B - Preparation technology of Gu Chisan for treating periodontitis - Google Patents
Preparation technology of Gu Chisan for treating periodontitis Download PDFInfo
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Abstract
The invention discloses a preparation technology of Gu Chisan for treating periodontitis. Gu Chisan comprises tortoise shell, halitum, Ligusticum wallichii, Cyperus Rotundus L, lotus leaf, Chinese prickly ash, hibiscus syriacus linn and dahurian angelica root. The process includes: A. pretreating raw medicinal materials; B. pulverizing the medicinal materials, i.e. pulverizing the dried net medicinal materials that are cooled to room temperature respectively in a rough grinding machine into rough powder, and sieving the powder through a sieve of 80 meshes; C. disinfecting the rough powder of all medicinal materials with oxirane; D. due to a high water content of the disinfected medicinal rough powder, drying the rough powder of all medicinal materials in a baking oven to a water content of 5.0-6.0%; E. pulverizing and sieving, i.e. pulverizing the dried rough powder of all medicinal materials respectively into finest powder in a fine grinding machine, and sieving through a sieve of 120 meshes so as to obtain finest powder of each medicinal materials; F. weighing, proportioning and packaging: weighing and charging the finest powder of each medicinal material based on a mass ratio of the components, mixing the finest powder overall; charging separately and packaging hermetically the mixed finest powder, thus obtaining a finished product. The preparation technology is characterized by high degree of mechanical automation, further guaranteed quality, low labor intensity and high production efficiency.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of treating periodontitis, particularly a kind of method for preparing of treating the teeth-strengthening powder of periodontitis.
Background technology
Periodontitis is a chronic inflammatory disease of invading gingiva and periodontal tissue, is a kind of destructive disease, and its principal character is the formation of periodontal pocket and the inflammation of bag wall, and frontal resorption and tooth are loosening gradually, and it is the main cause that causes adult's loss of tooth.Many because the bacterial plaque of primary disease, tartar, food impaction, bad dummy is stung wound etc. and is caused that various focusing depths represented swelling makes bacterial plaque pile up simultaneously and increases the weight of, and is expanded down by gingivally on the gum and to prolong.Because microecological environment under the gum is growing a large amount of bigger periodontal pathogenic bacterium of virulence, like the gingiva bacteroid in the subgingival plaque; Intermediate bacillus, spirillums etc. increase the weight of the inflammation of gingiva and expand and prolong; Cause periodontal pocket to form and frontal resorption, cause periodontitis.Periodontitis can aggravate gingival atrophy again conversely, quickens alveolar bone and is absorbed, and forms a kind of vicious cycle.
Chinese patent publication number CN1170580 discloses a kind of Chinese medicine composition-teeth consolidating of treating periodontitis and has increased bone and loose, and its prescription comprises Carapax Et Plastrum Testudinis, halite, Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae.
This medicine is to the therapeutical effect of periodontal disease, adopts Cavia porcellus periodontal disease model due to the no vitamin C feedstuff, observes the pathological change at positions such as gingiva, periodontal membrane, alveolar bone, dental pulp.The result confirms, the various pathological changes of teeth-strengthening powder group are all in model control group, and the visible new dentification of three animals is arranged, and obvious therapeutic action (P＜0.05) is arranged.The antiinflammatory experiment confirm, teeth-strengthening powder all has obvious therapeutic action (P＜0.05) to the shallow table property inflammation of animal skins, deep tissues inflammation and gingivitis; Teeth-strengthening powder also carries out to periodontal disease that sexually transmitted disease (STD) becomes and scorching card pathological changes has obvious treatment effect (P＜0.05).
Ancillary test teeth-strengthening powder as a result is painful to the visible effect trend of pain threshold, but statistics P＞0.05, teeth-strengthening powder is to hemorrhage visible effect trend, and teeth-strengthening powder does not have obvious inhibitory action.
The acute toxicity test of animal shows that the oral maximum tolerated dose of teeth-strengthening powder mice is 120g crude drug/kg body weight, for facing 7200 times of ordering consumption (people face order consumption be 1g/ days).
Long-term toxicity test for animals shows that teeth-strengthening powder does not have obvious influence to biochemical indicator such as Wistar rat body weight, hemogram, the heart, liver, renal function and electrocardiogram, and each internal organs reaches under the mirror inspection substantially and do not see that all the pathology toxic changes (P＞0.05).
Teeth-strengthening powder is to the no obvious stimulation effect of the complete oral mucosa of animal (gingiva).
Teeth-strengthening powder is to no obvious irritation such as the damaged infections of damaged oral mucosa (gingiva), hemorrhage, edema, and certain therapeutical effect is arranged, and promotes to take a turn for the better, healing.
Its technological process is: by the selected above-mentioned all components of proportioning, Carapax Et Plastrum Testudinis is fried to yellow, vinegar soaks the rinsing oven dry; With Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis, Radix Angelicae Dahuricae drying; The little stir-fry of Pericarpium Zanthoxyli; The Cortex Hibisci steeping in wine is dry; The halite oven dry.The Chinese medicine of then above-mentioned eight flavors being handled is pulverized mix homogeneously, quality inspection packing.
Wherein Carapax Et Plastrum Testudinis is fried to yellow, and vinegar soaks the rinsing oven dry and sieves for sand Carapax Et Plastrum Testudinis being fried to yellow the taking-up, after the clear water rinsing, dries or dry for standby again, and bake out temperature is controlled at 105-120 ℃, and every 100Kg Carapax Et Plastrum Testudinis is used vinegar 30Kg.
Wherein Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis, Radix Angelicae Dahuricae baking temperature are below 60 ℃.
Wherein the little stir-fry of Pericarpium Zanthoxyli be with little little stir-fry jumped ten minutes or burned (can not carbonization) subsequent use.
Wherein Cortex Hibisci steeping in wine drying is to add soaking in Chinese liquor two hours after Cortex Hibisci is dried, the control dry wine, and dry back is subsequent use, and baking temperature is controlled at below 80 ℃, medical material: wine=1:1.
Wherein the halite oven dry is meant that halite is subsequent use with oven for drying after drying, and temperature is controlled at 160-180 ℃.
Chinese medicine sterilization degerming method has multiple: steam sterilization, dry heat sterilization, microwave sterilizating, gaseous sterilization, irradiation sterilization and EK etc.Owing to teeth consolidating increases the diffusing above-mentioned preparation reason of bone; Particularly in the work in-process medicine process, Chinese crude drug will pass through the storing of certain hour, and noxious bacteria (like mycete) is present in the Chinese crude drug like this; Bad when storing medicine in moisture Control; The teeth consolidating of preparation increases bone and looses processing not through process for sterilizing, just pollutes easily, has a strong impact on drug effect; Teeth consolidating increases bone and is dispersed in that longest term is 1 year in the use.In the Chinese medicine crushing process, can cause amounts of dust, can personnel's health be worked the mischief to a certain extent.Temperature surpasses 100 ℃ in the preparation process, forms local carbonization easily, influences herbal medicine efficacy.Handmade teeth consolidating increases the diffusing quality of bone and can not get guaranteeing in different lot number concordance.
Summary of the invention
Spy of the present invention provides a kind of cold sterilization, fast release, medicament contg is high, evident in efficacy, effective time is grown teeth-strengthening powder preparation technology.
The technical scheme that the present invention adopts:
A kind of preparation technology who treats the teeth-strengthening powder of periodontitis, its component comprises Carapax Et Plastrum Testudinis, halite, Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, said component is Carapax Et Plastrum Testudinis 27, halite 27 by the quality proportioning; Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis each 18; Pericarpium Zanthoxyli, Cortex Hibisci each 15, the Radix Angelicae Dahuricae 12
Its technological process comprises
The pretreatment of A crude drug
Carapax Et Plastrum Testudinis: with Carapax Et Plastrum Testudinis be dipped to skin and flesh soft after, the residual meat that adheres to above eliminating with hard brush (or wire brush), and clean, drying under 75-80 ℃ of condition with the clear water rinsing;
Halite: after cleaning, with 75-80 ℃ of drying;
Rhizoma Chuanxiong: after cleaning, wash profit, section is 55-60 ℃ of drying;
Rhizoma Cyperi: remove impurity and feeler, run through, shave is 55-60 ℃ of drying;
Folium Nelumbinis: water spray, to moisten slightly, shredding is 55-60 ℃ of drying;
Pericarpium Zanthoxyli: select, remove seed and impurity, 55-60 ℃ of drying;
Cortex Hibisci: clean, run through, cutting is with 75-80 ℃ of drying;
The Radix Angelicae Dahuricae: after cleaning, clean, run through, section is 55-60 ℃ of drying;
Wherein carry out drying at baking oven after all crude drug pretreatment, dry back medicine moisture content is no more than 6.0%;
Section is carried out at reciprocating type medicine cutter;
The B pulverizing medicinal materials
Dry back is also put to the clean medical material of room temperature and is ground into medicinal material coarse powder at the coarse powder machine respectively, and sieves through 80 eye mesh screens; Wherein the Carapax Et Plastrum Testudinis quality is hard, earlier separately with being ground into medicinal material coarse powder after the crusher in crushing again;
The C sterilization
Utilize oxirane to each medicinal material coarse powder sterilization;
D is dry
Medicinal material coarse powder water content after the sterilization is higher, must carry out drying at heated-air circulation oven, places baking oven inner drying to moisture at 5.0-6.0% each medicinal material coarse powder;
E pulverizes, sieves
Each medicinal material coarse powder after the oven dry placed respectively be ground into fine powder in the pulverizing mill, and sieve, the fine powder of each that obtains through 120 eye mesh screens;
F weighing, batching, packing
The fine powder of each medicine is fed intake by the weighing of component quality proportioning, by " equivalent incremental method " mixing of sieving, change in the three-dimensional mixer and always mix when feeding intake;
Medicated powder after will always mixing then packs in the packing of micropowder filling machine, gets product;
Above-mentioned C, D, E, F step are carried out in sterilizing room, and each medicinal material coarse powder article is identical with the baking temperature of A step at the baking temperature of described D step.
Described ethylene oxide sterilizing, its step
C1 will be to be sterilized medicinal material coarse powder place in the steriliser airtightly, be heated to 55 ℃, with vacuum pump aseptic device is evacuated to vacuum;
C2 feeds the oxirane mist in aseptic device, wherein oxirane 10%, carbon dioxide 90%, and keep ethylene oxide concentration 450 ㎎/L, and temperature 53-57 ℃, relative humidity 60%, sterilization is more than 6 hours;
After C3 sterilization finishes, the oxirane of remnants is fed in the water, discharge after being converted into ethylene glycol;
Medicinal material coarse powder after the C4 sterilization places in the constant temperature Ventilation Control district of air cleaning system, and remaining oxirane volatilization is dispersed.
The described temperature of C2 step is 55 ℃, and the temperature in the described constant temperature Ventilation Control of C3 step district is identical at the described baking temperature of A step with each medicine.
Said total mix to pour into for the fine powder of each medicine that will prepare carry out in the described three-dimensional mixer, institute's powder charge powder amount must not surpass 2/3 of mixer capacity, incorporation time is 15～30min.
The teeth-strengthening powder of this prepared meets State Drug Administration's standard (trying) WS-404 (Z-060)-2000, specifically sees table
The teeth-strengthening powder usage and dosage of this prepared: temper, embrocate the gingiva place.Each 0.5g, a twice-daily was embrocated 2～3 minutes at every turn.
Two clinical stages of the teeth-strengthening powder II phase of this prepared carry out simultaneously, observe patient's 130 examples altogether.Test group 100 examples, total effective rate are 92.6%; Wherein obvious effective rate is 40.5%, matched group 30 examples, total effective rate 89.8%; Wherein obvious effective rate is 22%.The obvious effective rate of test group is significantly higher than matched group.Do not find in the clinical trial process that this medicine has obvious toxic and side effects and untoward reaction, safe and reliable, be effective preparation of treatment renal deficiency type gingival atrophy (periodontitis).
Effect cures mainly: has the function of nourishing YIN for benefiting the kidney, promoting blood circulation and detumescence, relieving pain and strengthening teeth, cures mainly gingival atrophy, be used for deficiency of kidney-YIN, and stagnation of QI-blood, swelling of the gum suppurates, and chews pain, the patients with periodontitis that odontoseisis, alveolar bone are shunk back.Have strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease, evident in efficacy.
The invention has the beneficial effects as follows:
1 through the oxirane cold sterilization, has both kept the biological nature of medicine, makes sterilization more thorough again.The sterilizing methods listed with respect to background technology, teeth-strengthening powder adopt the sterilization of oxirane mist, and through the checking of sterilization effect, the sterilization of this kind method meets the product technological requirement fully.Because ethylene oxide sterilizing is taked mist, wherein oxirane 10%, carbon dioxide 90%, and ethylene oxide concentration is low, and safety coefficient is high, and noresidue can not work the mischief to human body.Non-specific alkylating can take place with the protein dna and the RNA of microorganism in oxirane; Can with free carboxy, amino, sulfydryl and the hydroxyl generation alkylating on the proteinogen in the protein of microorganism, replace labile hydrogen atom and form the chemical compound that has ethoxy.Thereby make the somatic cells metabolism that irreversible infringement take place, thereby reach sterilization effect.Through experiment showed, oxirane at concentration 450mg/L, 55 ℃ of temperature, relative humidity 40 ~ 60%, sterilization time were kept 6 hours, and the effect of sterilization is best.Avoided the employing steam sterilization, the volatile ingredient destructible, the irradiation sterilization cost is higher, and the time is long, is unfavorable for suitability for industrialized production.
2 because through twice drying; Moisture below 5.0% in the biological nature that has kept medicine simultaneously; Messenger drug has long effective shelf-life (effect duration of this teeth-strengthening powder is 18 months); And, adapt to the industrialization quality management more in the course of processing every kind of component moisture content being required unanimity and qualitative 6.0% and 5.0% standard is arranged respectively.
Be machining at low temperature in 3 whole process of production, temperature does not surpass 80 ℃, has avoided causing carbonization process, has helped to keep the biological nature of medicine yet.
Medicinal material coarse powder after will drying in 4 production processes places respectively in the pulverizing mill and pulverizes, and no dust pollution helps work and protects and environmental protection.
The medicine teeth-strengthening powder fine powder of 5 technologies is 120 orders, and the gross area of medicine increases, and has increased the medicine contact area, thereby has made medicine improve availability, brings into play efficient, quick-acting effects.
6 preparation technology's mechanical automation degree are high, and quality is guaranteed that further labor intensity is low, and production efficiency is high.
The specific embodiment
Embodiment 1
To fill a prescription is Carapax Et Plastrum Testudinis 27Kg, halite 27Kg, Rhizoma Chuanxiong, Rhizoma Cyperi, each 18Kg of Folium Nelumbinis, and Pericarpium Zanthoxyli, each 15Kg of Cortex Hibisci, Radix Angelicae Dahuricae 12Kg, total dose 150Kg is one group; Every group is prepared into 30000 boxes.
The crude drug pretreatment
Carapax Et Plastrum Testudinis: with Carapax Et Plastrum Testudinis be dipped to skin and flesh soft after, the residual meat that adheres to above eliminating with hard brush (or wire brush), and clean with the clear water rinsing is dried to moisture content and is no more than 6.0% under 75 ℃ of conditions.
Halite: after cleaning, be dried to moisture content below 6.0% with 75.
Rhizoma Chuanxiong: after cleaning, wash profit, section is dried to moisture content at 55 ℃ and is no more than 6.0%.
Rhizoma Cyperi: remove impurity and feeler, run through, shave is dried to moisture content at 55-60 ℃ and is no more than 6.0%.
Folium Nelumbinis: water spray, to moisten slightly, shredding is dried to moisture content at 55 ℃ and is no more than 6.0%.
Pericarpium Zanthoxyli: select, remove seed and impurity, be dried to moisture content at 55 ℃ and be no more than 6.0%.
Cortex Hibisci: clean, run through, cutting is being dried to moisture content 6.0% with 75 ℃.
The Radix Angelicae Dahuricae: after cleaning, clean, run through, section is dried to moisture content at 55 ℃ and is no more than 6.0%.
Pulverizing medicinal materials (group powder):
With after the drying and put to the clean medical material pulverize separately of room temperature and become coarse powder, the Carapax Et Plastrum Testudinis quality is hard, need be earlier separately with being ground into coarse powder after the crusher in crushing again by the S.O.P. (SOP) of CSJ type boulder crusher.
The article storehouse is temporary in the middle of going into:
Medicinal material coarse powder after crushed is respectively charged in the clean container, weighing, and fill on request and place the material Status Flag, article are deposited between keeping in the middle of sending into.
Sterilization (ethylene oxide sterilizing)
Medicinal material coarse powder to be sterilized led out between temporary from the centre article be placed in the steriliser airtightly, be heated to 53 ℃, aseptic device is evacuated to vacuum with vacuum pump.
In aseptic device, feed oxirane mist (oxirane 10%, carbon dioxide 90%), and keep ethylene oxide concentration 450 ㎎/L, 53 ℃ of temperature, relative humidity 60%, sterilization is more than 6 hours.
After sterilization finishes, the oxirane of remnants is fed in the water, discharge after being converted into ethylene glycol.
Medicine after the sterilization places in the constant temperature Ventilation Control district of air cleaning system, and remaining oxirane branch is dispersed.
Dry
Medicinal material coarse powder water content after the sterilization is higher, must carry out drying, and the S.O.P. of pressing heated-air circulation oven places baking oven inner drying to moisture below 5.0% medicinal material coarse powder; The exsiccant temperature of various medical material institutes is identical with the various medical materials of a steps A exsiccant temperature.
Pulverize, (fine powder) sieves:
Medicinal material coarse powder after the oven dry placed respectively be ground into fine powder in the pulverizing mill, and sieve through 120 eye mesh screens.With the fine powder weighing of having crossed sieve, stick the material Status Flag, change material over to and deposit between temporary.
Weighing, batching
The fine powder of medicine feeds intake by the prescription weighing through after the assay was approved, by " equivalent incremental method " mixings of sieving, changes in the three-dimensional mixer always mixed then when feeding intake.
Total mixing
The fine powder of the above-mentioned material for preparing poured into mix in the three-dimensional mixer, institute's powder charge powder amount must not surpass 2/3 of mixer capacity; Incorporation time is 15～30min, and every mixing is once as a product batch number, and the medicated powder with mix homogeneously is sub-packed in weighing in the clean container at last, and fills in the material Status Flag by regulation, is attached on the container, and it is temporary to send into intermediate station.
Fill (packing):
Semi-finished product after total the mixing through inspect by random samples by regulation qualified after, get the micropowder filling machine from intermediate station and carry out packing, and spot-check content uniformity at any time by the specification of 5g/ bottle, carry out quality monitoring.
Spiral cover:
The semi-finished product that branch installed by the regulation requirement bottle cap (preventing that medicated powder from spilling) of screwing.
Packing
Beat sign indicating number: code operations is beaten in the requirement by HP-241B coder S.O.P..
Labeling: labelled to every medicine bottle by the regulation requirement.Note rejecting obvious loading amount deficiency or the not tight medicine of spiral cover during labeling.
Dress box: by box in per 10 bottle of one box.
Vanning, packing: case for one case by box in per 20.
Finished product warehouse-in to be tested
Through the qualified article to be checked of final inspection, handle the warehouse-in formality with the product inspection statement of quality monitoring portion stamped signature and finished product Rleasing Notice list and send into the warehouse.
Embodiment 2
Carapax Et Plastrum Testudinis: with Carapax Et Plastrum Testudinis be dipped to skin and flesh soft after, the residual meat that adheres to above eliminating with hard brush (or wire brush), and clean, drying under 78 ℃ of conditions with the clear water rinsing;
Halite: after cleaning, with 78 ℃ of dryings;
Rhizoma Chuanxiong: after cleaning, wash profit, section is 57 ℃ of dryings;
Rhizoma Cyperi: remove impurity and feeler, run through, shave is 57 ℃ of dryings;
Folium Nelumbinis: water spray, to moisten slightly, shredding is 57 ℃ of dryings;
Pericarpium Zanthoxyli: select, remove seed and impurity, 57 ℃ of dryings;
Cortex Hibisci: clean, run through, cutting is with 57 ℃ of dryings;
The Radix Angelicae Dahuricae: after cleaning, clean, run through, section is 57 ℃ of dryings;
Other step with
Embodiment 1It is identical.
Embodiment 3
Carapax Et Plastrum Testudinis: with Carapax Et Plastrum Testudinis be dipped to skin and flesh soft after, the residual meat that adheres to above eliminating with hard brush (or wire brush), and clean, drying under 80 ℃ of conditions with the clear water rinsing;
Halite: after cleaning, with 80 ℃ of dryings;
Rhizoma Chuanxiong: after cleaning, wash profit, section is 60 ℃ of dryings;
Rhizoma Cyperi: remove impurity and feeler, run through, shave is 60 ℃ of dryings;
Folium Nelumbinis: water spray, to moisten slightly, shredding is 60 ℃ of dryings;
Pericarpium Zanthoxyli: select, remove seed and impurity, 60 ℃ of dryings;
Cortex Hibisci: clean, run through, cutting is 80 ℃ of dryings;
The Radix Angelicae Dahuricae: after cleaning, clean, run through, section is 60 ℃ of dryings;
Other step with
Embodiment 1Identical.
Each step just gets into the sterilizing room operation from the C step in more than implementing, and the baking temperature of the temperature in the described constant temperature Ventilation Control of each medicine district and the drying of steps A and step D is identical.
The equivalent incremental method: refer to earlier the few component of the amount of getting, add the big component of amount of equivalent, get the big component mix homogeneously of amount with mixture equivalent again, so doubly amount increases, until whole mix homogeneously, and the mixed method that color and luster is consistent.
Through the optimization of above production technology, constant product quality, the production cycle shortens, product cost obviously descends, the market share significantly improves, when annual turnover by having gone up 5 times, the raising of economic benefit is conspicuous.
Claims (1)
1. preparation technology who treats the teeth-strengthening powder of periodontitis, its component comprises Carapax Et Plastrum Testudinis, halite, Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis, Pericarpium Zanthoxyli, Cortex Hibisci, the Radix Angelicae Dahuricae, said component is Carapax Et Plastrum Testudinis 27, halite 27 by the quality proportioning; Rhizoma Chuanxiong, Rhizoma Cyperi, Folium Nelumbinis each 18; Pericarpium Zanthoxyli, Cortex Hibisci each 15, the Radix Angelicae Dahuricae 12
Its technological process comprises
The pretreatment of A crude drug
Carapax Et Plastrum Testudinis: with Carapax Et Plastrum Testudinis be dipped to skin and flesh soft after, the residual meat that adheres to above eliminating with hard brush or wire brush, and clean, drying under 75-80 ℃ of condition with the clear water rinsing;
Halite: after cleaning, with 75-80 ℃ of drying;
Rhizoma Chuanxiong: after cleaning, wash profit, section is 55-60 ℃ of drying;
Rhizoma Cyperi: remove impurity and feeler, run through, shave is 55-60 ℃ of drying;
Folium Nelumbinis: water spray, to moisten slightly, shredding is 55-60 ℃ of drying;
Pericarpium Zanthoxyli: select, remove seed and impurity, 55-60 ℃ of drying;
Cortex Hibisci: clean, run through, cutting is with 75-80 ℃ of drying;
The Radix Angelicae Dahuricae: after cleaning, clean, run through, section is 55-60 ℃ of drying;
Wherein carry out drying at baking oven after all crude drug pretreatment, dry back medicine moisture is no more than 6.0%;
Section is carried out at reciprocating type medicine cutter;
The B pulverizing medicinal materials
Dry back is also put to the clean medical material of room temperature and is ground into medicinal material coarse powder at the coarse powder machine respectively, and sieves through 80 eye mesh screens; Wherein the Carapax Et Plastrum Testudinis quality is hard, earlier separately with being ground into medicinal material coarse powder after the crusher in crushing again;
The C sterilization
Utilize oxirane to each medicinal material coarse powder sterilization;
D is dry
Medicinal material coarse powder water content after the sterilization is higher, must carry out drying at heated-air circulation oven, places baking oven inner drying to moisture at 5.0-6.0% each medicinal material coarse powder;
E pulverizes, sieves
Each medicinal material coarse powder after the oven dry placed respectively be ground into fine powder in the pulverizing mill, and sieve, the fine powder of each that obtains through 120 eye mesh screens;
F weighing, batching, packing
The fine powder of each medicine is fed intake by the weighing of constituent mass proportioning, by the mixing of sieving of equivalent incremental method, change in the three-dimensional mixer and always mix when feeding intake;
Medicated powder after will always mixing then packs in the packing of micropowder filling machine, gets product;
Above-mentioned C, D, E, F step are carried out in sterilizing room, and each medicinal material coarse powder article is identical with the baking temperature of A step at the baking temperature of described D step;
Described ethylene oxide sterilizing, its step comprises:
C1 will be to be sterilized medicinal material coarse powder place in the steriliser airtightly, be heated to 55 ℃, with vacuum pump aseptic device is evacuated to vacuum;
C2 feeds the oxirane mist in aseptic device, wherein oxirane 10%, carbon dioxide 90%, and keep ethylene oxide concentration 450 ㎎/L, and temperature 53-57 ℃, relative humidity 60%, sterilization is more than 6 hours;
After C3 sterilization finishes, the oxirane of remnants is fed in the water, discharge after being converted into ethylene glycol;
Medicinal material coarse powder after the C4 sterilization places in the constant temperature Ventilation Control district of air cleaning system, and remaining oxirane volatilization is dispersed; The described temperature of C2 step is 55 ℃, and the temperature in the described constant temperature Ventilation Control of C4 step district is identical at the described baking temperature of A step with each medicine; Said total mix to pour into for the fine powder of each medicine that will prepare carry out in the described three-dimensional mixer, institute's powder charge powder amount must not surpass 2/3 of mixer capacity; Incorporation time is 15～30min.
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| CN2011101172868A CN102188585B (en) | 2011-05-09 | 2011-05-09 | Preparation technology of Gu Chisan for treating periodontitis |
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| CN2011101172868A CN102188585B (en) | 2011-05-09 | 2011-05-09 | Preparation technology of Gu Chisan for treating periodontitis |
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| CN102188585B true CN102188585B (en) | 2012-12-19 |
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| CN102727810B (en) * | 2012-07-20 | 2013-07-24 | 王芳 | Medicinal composition for treating gingivitis |
| CN103222947B (en) * | 2013-05-08 | 2014-12-03 | 苏敏华 | Traditional Chinese medicinal composition for treating periodontitis |
| CN104547856B (en) * | 2014-12-18 | 2018-02-23 | 苏敏华 | A kind of Chinese medicine composition for treating periodontitis, gel preparation and preparation method thereof |
| CN106880720A (en) * | 2015-12-15 | 2017-06-23 | 夏杰 | A kind of Chinese medicine composition for treating periodontitis |
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| CN1170580A (en) * | 1996-07-17 | 1998-01-21 | 董广安 | Chinese drug composition for curing periodontitis |
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