CN104547490B - A kind of medicine for treating periodontal disease and preparation method thereof - Google Patents

A kind of medicine for treating periodontal disease and preparation method thereof Download PDF

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Publication number
CN104547490B
CN104547490B CN201510000906.8A CN201510000906A CN104547490B CN 104547490 B CN104547490 B CN 104547490B CN 201510000906 A CN201510000906 A CN 201510000906A CN 104547490 B CN104547490 B CN 104547490B
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parts
medicine
multitude
spider
periodontal disease
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CN104547490A (en
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梁鹤耀
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HAINAN ZHUWANG PHARMACEUTICAL Co Ltd
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HAINAN ZHUWANG PHARMACEUTICAL Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • Microbiology (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
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Abstract

The present invention provides a kind of medicine for treating periodontal disease and preparation method thereof, the medicine is the alcohol extract of following compositions：8~25 parts of 20~50 parts of spider freeze-drying powder, 15~40 parts of pseudo-ginseng, 10~35 parts of the radix paeoniae rubrathe, 10~35 parts of Fructus Forsythiae, 10~35 parts of asarum, 10~35 parts of honeysuckle, 8~25 parts of safflower, 8~25 parts of chrysanthemum and fritillaria thunbergii.Its preparation method is：Composition is added in alcohol, soaks 5~10 days, then boils at least 20min, is cooled down, filtering, both.The present invention is suitable for treating a variety of periodontal diseases, there is good effect to dental caries and toothache, anemopyretic toothache, gingivitis, periodontal band inflammation, pericoronitis, periapicalitis etc., the rapid alleviating pain and detumescence of energy, anti-inflammatory is antibacterial, securely and reliably, and low with production cost, technique is simple, can carry with, it is easy to use the advantages that.

Description

A kind of medicine for treating periodontal disease and preparation method thereof
Technical field
The invention belongs to drug field, more particularly to a kind of medicine for treating periodontal disease and preparation method thereof.
Background technology
For toothache caused by dental caries and toothache, anemopyretic toothache, gingivitis, periodontal band inflammation, pericoronitis, periapicalitis etc. Disease is that one kind makes one agonizing common disease, due to there is presently no suitable family it is standing treatment toothache medicine, so It can only go to treat to hospital, but often patient is added pain because that cannot get timely medical treatment.
The content of the invention
It is an object of the present invention to provide a kind of multitude's drug composition for treating periodontal disease, another purpose is to provide one Kind treats the medicine of periodontal disease, and further object is to provide a kind of preparation method for the medicine for treating periodontal disease.
The first aspect of the invention there is provided a kind of multitude's drug composition for treating periodontal disease, according to mass fraction Meter, multitude's drug composition include 20~50 parts of spider freeze-drying powder, 15~40 parts of pseudo-ginseng, 10~35 parts of the radix paeoniae rubrathe, Fructus Forsythiae 10~35 8~25 parts of part, 10~35 parts of asarum, 10~35 parts of honeysuckle, 8~25 parts of safflower, 8~25 parts of chrysanthemum and fritillaria thunbergii.
Preferably, 30~40 parts of spider freeze-drying powder, pseudo-ginseng 22~32 are included according to mass fraction meter, multitude's drug composition Part, 18~28 parts of the radix paeoniae rubrathe, 20~30 parts of Fructus Forsythiae, 20~30 parts of asarum, 20~30 parts of honeysuckle, 12~20 parts of safflower, chrysanthemum 12 ~20 parts and 12~20 parts of fritillaria thunbergii.
Preferably, according to mass fraction meter, according to mass fraction meter, multitude's drug composition includes spider freeze-drying powder 38 Part, 26 parts of pseudo-ginseng, 22 parts of the radix paeoniae rubrathe, 28 parts of Fructus Forsythiae, 24 parts of asarum, 26 parts of honeysuckle, 15 parts of safflower, 18 parts of chrysanthemum and fritillaria thunbergii 15 Part.
Preferably, the spider freeze-drying powder uses Hainan Jingzhao chilobrachys spider.
The second aspect of the invention is to provide a kind of medicine for treating periodontal disease, and the active ingredient of the medicine is power Profit requires the alcohol extract of multitude's drug composition described in any one in 1~5.
The medicine can be prepared into various external used medicines, such as tincture, pulvis etc..
The third aspect of the invention is to provide the system of the medicine of the treatment periodontal disease described in second aspect of the present invention Preparation Method：The multitude's drug composition of any one described in the first aspect of the present invention is taken, is added in alcohol, immersion 5~10 days, so After boil at least 20min, cool down, filtering, both.
Preferably, obtained product is diluted with water, tincture is made.
Preferably, obtained product is concentrated and dried, pulvis is made.
The present invention is suitable for treating a variety of periodontal diseases, to dental caries and toothache, anemopyretic toothache, gingivitis, periodontal band inflammation, corona Zhou Yan, periapicalitis etc. have good effect, and the rapid alleviating pain and detumescence of energy, anti-inflammatory is antibacterial, securely and reliably, and have and are produced into This is low, and technique is simple, can carry with, it is easy to use the advantages that.
Embodiment
With reference to specific embodiment, the present invention is described further, to more fully understand the present invention.
Embodiment 1
By the fresh cadaver of Hainan Jingzhao chilobrachys spider or the cleaned processing of part of limb, after being rinsed with clear water, liquid nitrogen is put into Or the method for low temperature refrigerator is freezed, after freezing reality, the common freeze dryer after precooling is put into, after to be dried, with common mortar, is ground Grinding machine or other methods grinding are made powdery and are sealed；Alternatively, after the full worm of spider or limbs freeze reality, first ground with conventional method Powdery is worn into, places into freeze drying equipment, freeze-dried powder is made.
Weigh raw material：It is spider freeze-drying powder 20g, pseudo-ginseng 140g, radix paeoniae rubrathe 10g, Fructus Forsythiae 35g, asarum 10g, honeysuckle 35g, red Flower 8g, chrysanthemum 25g and fritillaria thunbergii 8g.Add the raw material into 700ml alcohol, immersion 5~10 days, then boiling reflux 30min, Cooling, filtering, then adds the dilution of 1200ml water, must both treat the tincture of periodontal disease.
Embodiment 2
By the fresh cadaver of Hainan Jingzhao chilobrachys spider or the cleaned processing of part of limb, after being rinsed with clear water, liquid nitrogen is put into Or the method for low temperature refrigerator is freezed, after freezing reality, the common freeze dryer after precooling is put into, after to be dried, with common mortar, is ground Grinding machine or other methods grinding are made powdery and are sealed；Alternatively, after the full worm of spider or limbs freeze reality, first ground with conventional method Powdery is worn into, places into freeze drying equipment, freeze-dried powder is made.
Weigh raw material：Spider freeze-drying powder 50g, pseudo-ginseng 15g, radix paeoniae rubrathe 35g, Fructus Forsythiae 10g, asarum 35g, honeysuckle 10g, safflower 25g, chrysanthemum 8g and fritillaria thunbergii 25g.Add the raw material into 900ml alcohol, immersion 5~10 days, then boiling reflux 30min, Cooling, is filtered, and is concentrated and dried, and the pulvis for the treatment of periodontal disease is made.
Embodiment 3
By the fresh cadaver of Hainan Jingzhao chilobrachys spider or the cleaned processing of part of limb, after being rinsed with clear water, liquid nitrogen is put into Or the method for low temperature refrigerator is freezed, after freezing reality, the common freeze dryer after precooling is put into, after to be dried, with common mortar, is ground Grinding machine or other methods grinding are made powdery and are sealed；Alternatively, after the full worm of spider or limbs freeze reality, first ground with conventional method Powdery is worn into, places into freeze drying equipment, freeze-dried powder is made.
Weigh raw material：Spider freeze-drying powder 30g, pseudo-ginseng 32g, radix paeoniae rubrathe 18g, Fructus Forsythiae 30g, asarum 20g, honeysuckle 30g, safflower 12g, chrysanthemum 20g and fritillaria thunbergii 12g.Add the raw material into 1200ml alcohol, immersion 5~10 days, then boiling reflux 30min, cools down, filtering, then adds the dilution of 1000ml water, must both treat the tincture of periodontal disease.
Embodiment 4
By the fresh cadaver of Hainan Jingzhao chilobrachys spider or the cleaned processing of part of limb, after being rinsed with clear water, liquid nitrogen is put into Or the method for low temperature refrigerator is freezed, after freezing reality, the common freeze dryer after precooling is put into, after to be dried, with common mortar, is ground Grinding machine or other methods grinding are made powdery and are sealed；Alternatively, after the full worm of spider or limbs freeze reality, first ground with conventional method Powdery is worn into, places into freeze drying equipment, freeze-dried powder is made.
Weigh raw material：Spider freeze-drying powder 40g, pseudo-ginseng 22g, radix paeoniae rubrathe 28g, Fructus Forsythiae 20g, asarum 30g, honeysuckle 20g, safflower 20g, chrysanthemum 12g and fritillaria thunbergii 20g.Add the raw material into 1200ml alcohol, immersion 5~10 days, then boiling reflux 30min, cools down, and filters, and is concentrated and dried, and the pulvis for the treatment of periodontal disease is made.
Embodiment 5
By the fresh cadaver of Hainan Jingzhao chilobrachys spider or the cleaned processing of part of limb, after being rinsed with clear water, liquid nitrogen is put into Or the method for low temperature refrigerator is freezed, after freezing reality, the common freeze dryer after precooling is put into, after to be dried, with common mortar, is ground Grinding machine or other methods grinding are made powdery and are sealed；Alternatively, after the full worm of spider or limbs freeze reality, first ground with conventional method Powdery is worn into, places into freeze drying equipment, freeze-dried powder is made.
Weigh raw material：Spider freeze-drying powder 38g, pseudo-ginseng 26g, radix paeoniae rubrathe 22g, Fructus Forsythiae 28g, asarum 24g, honeysuckle 26g, safflower 15g, chrysanthemum 18g and fritillaria thunbergii 15g.Add the raw material into 1200ml alcohol, immersion 5~10 days, then boiling reflux 30min, cools down, and filters, and is concentrated and dried, and the pulvis for the treatment of periodontal disease is made.
Scorching dental caries and toothache, anemopyretic toothache, gingivitis, periodontal band, pericoronitis and periapicalitis patient are collected, using this Invention provides the medicine that embodiment 1~5 provides and carries out clinical test.Tincture application method：It is painted on affected part or uses cotton Ball dips after tincture solution plug in affected part, one day 3~5 times；The application method of pulvis：Powder of getting it filled is embrocated in affected part, one day 3~5 It is secondary.The treatment after medication 2 days is counted, testing result is shown in Table 1, and each embodiment is 30 for the patient numbers of every kind of disease People.
As shown in Table 1, when treating 2 days, at least more than 2/3 patient's present invention is fully recovered, and effective percentage reaches 100%, in addition, the patient's continual cure do not fully recovered after treating 2 days, after 7 days, patient, which is substantially all, to be fully recovered.And 30 days Interior no relapse.Illustrate that the drug therapy periodontal disease of the present invention is evident in efficacy.
The specific embodiment of the present invention is described in detail above, but it is intended only as example, it is of the invention and unlimited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and Substitute also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and Modification, all should be contained within the scope of the invention.

Claims (5)

  1. A kind of 1. multitude's drug composition for treating periodontal disease, it is characterised in that according to mass fraction meter, multitude's drug composition by Following components forms：30~40 parts of spider freeze-drying powder, 22~32 parts of pseudo-ginseng, 18~28 parts of the radix paeoniae rubrathe, 20~30 parts of Fructus Forsythiae, asarum 20 12~20 parts of~30 parts, 20~30 parts of honeysuckle, 12~20 parts of safflower, 12~20 parts of chrysanthemum and fritillaria thunbergii；The spider freezes Powder uses Hainan Jingzhao chilobrachys spider.
  2. 2. multitude's drug composition according to claim 1, it is characterised in that according to mass fraction meter, multitude's drug composition It is composed of the following components：38 parts of spider freeze-drying powder, 26 parts of pseudo-ginseng, 22 parts of the radix paeoniae rubrathe, 28 parts of Fructus Forsythiae, 24 parts of asarum, 26 parts of honeysuckle, 15 parts of 15 parts of safflower, 18 parts of chrysanthemum and fritillaria thunbergii.
  3. 3. a kind of external used medicine for treating periodontal disease, it is characterised in that the active ingredient of the medicine is claim 1~2 The alcohol extract of multitude's drug composition described in middle any one.
  4. 4. external used medicine according to claim 3, it is characterised in that the medicine is tincture or pulvis.
  5. 5. a kind of preparation method for the treatment of periodontal disease external used medicine as claimed in claim 4, it is characterised in that weighting profit will Multitude's drug composition described in any one in 1~2 is sought, is added in alcohol, soaks 5~10 days, then boils at least 20min, Cooling, filtering, both.
CN201510000906.8A 2015-01-04 2015-01-04 A kind of medicine for treating periodontal disease and preparation method thereof Active CN104547490B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3078886A1 (en) * 2018-03-15 2019-09-20 Liu Zhengyu MEDICAMENT FOR TREATING TOOTHBORNE AND METHOD FOR PREPARING THE SAME

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110917059A (en) * 2020-01-02 2020-03-27 浙江寿仙谷健康科技有限公司 Efficacy agent of toothpaste with anti-inflammation and hemostasis effects, toothpaste containing efficacy agent and preparation method of toothpaste

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CN1108946A (en) * 1994-03-25 1995-09-27 伍传道 Tincture for toothache and its preparation
CN1839887A (en) * 2005-12-22 2006-10-04 清华大学深圳研究生院 Spider freeze-drying powder preparation method and its uses in medicine and health product

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Publication number Priority date Publication date Assignee Title
KR100605116B1 (en) * 2004-07-05 2006-07-31 주식회사 오스코텍 Composition comprising Notoginseng Radix extract for preventing and treating of periodentitis as an effective component

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1108946A (en) * 1994-03-25 1995-09-27 伍传道 Tincture for toothache and its preparation
CN1839887A (en) * 2005-12-22 2006-10-04 清华大学深圳研究生院 Spider freeze-drying powder preparation method and its uses in medicine and health product

Non-Patent Citations (1)

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Title
名中医牙痛医案63例中药配伍及方证对应规律分析;欧阳志强等;《江西中医学院学报》;20071031;第19卷(第5期);第88-90页，尤其是第90页右栏讨论 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3078886A1 (en) * 2018-03-15 2019-09-20 Liu Zhengyu MEDICAMENT FOR TREATING TOOTHBORNE AND METHOD FOR PREPARING THE SAME

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