FR3053253B1 - Nouvel extrait d'akenes de silybum marianum et ses utilisations en dermatologie et dermo-cosmetique - Google Patents

Nouvel extrait d'akenes de silybum marianum et ses utilisations en dermatologie et dermo-cosmetique Download PDF

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Publication number
FR3053253B1
FR3053253B1 FR1656328A FR1656328A FR3053253B1 FR 3053253 B1 FR3053253 B1 FR 3053253B1 FR 1656328 A FR1656328 A FR 1656328A FR 1656328 A FR1656328 A FR 1656328A FR 3053253 B1 FR3053253 B1 FR 3053253B1
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FR
France
Prior art keywords
silybum marianum
akenes
dermo
dermatology
cosmetics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1656328A
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English (en)
French (fr)
Other versions
FR3053253A1 (fr
Inventor
Jean Hilaire Saurat
Olivier Sorg
Mathieu LETI
Bernard Fabre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Dermo Cosmetique SA
Original Assignee
Pierre Fabre Dermo Cosmetique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1656328A priority Critical patent/FR3053253B1/fr
Application filed by Pierre Fabre Dermo Cosmetique SA filed Critical Pierre Fabre Dermo Cosmetique SA
Priority to AU2017291242A priority patent/AU2017291242B2/en
Priority to ARP170101827A priority patent/AR108935A1/es
Priority to EP17734335.7A priority patent/EP3478309B1/en
Priority to CN201780039477.2A priority patent/CN109414466B/zh
Priority to TW106122046A priority patent/TWI773676B/zh
Priority to RU2018145789A priority patent/RU2746724C2/ru
Priority to PL17734335T priority patent/PL3478309T3/pl
Priority to JP2018568390A priority patent/JP7233222B2/ja
Priority to US16/313,835 priority patent/US11285185B2/en
Priority to PT177343357T priority patent/PT3478309T/pt
Priority to MX2018016032A priority patent/MX394161B/es
Priority to SG11201811246RA priority patent/SG11201811246RA/en
Priority to CA3028025A priority patent/CA3028025C/en
Priority to BR112018076465-5A priority patent/BR112018076465B1/pt
Priority to ES17734335T priority patent/ES2882493T3/es
Priority to KR1020187037981A priority patent/KR102459649B1/ko
Priority to PCT/EP2017/066349 priority patent/WO2018002338A1/en
Priority to DK17734335.7T priority patent/DK3478309T3/da
Publication of FR3053253A1 publication Critical patent/FR3053253A1/fr
Priority to CL2018003827A priority patent/CL2018003827A1/es
Application granted granted Critical
Publication of FR3053253B1 publication Critical patent/FR3053253B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Birds (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FR1656328A 2016-07-01 2016-07-01 Nouvel extrait d'akenes de silybum marianum et ses utilisations en dermatologie et dermo-cosmetique Active FR3053253B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR1656328A FR3053253B1 (fr) 2016-07-01 2016-07-01 Nouvel extrait d'akenes de silybum marianum et ses utilisations en dermatologie et dermo-cosmetique
MX2018016032A MX394161B (es) 2016-07-01 2017-06-30 Nuevo extracto de aquenio silybum marianum y usos del mismo en la dermatología y dermocosméticos.
EP17734335.7A EP3478309B1 (en) 2016-07-01 2017-06-30 Novel silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics
CN201780039477.2A CN109414466B (zh) 2016-07-01 2017-06-30 新的水飞蓟瘦果提取物及其在皮肤病学和皮肤化妆品中的用途
TW106122046A TWI773676B (zh) 2016-07-01 2017-06-30 新穎之水飛薊(silybum marianum)瘦果萃取物以及其於皮膚科及皮膚化妝品的用途
RU2018145789A RU2746724C2 (ru) 2016-07-01 2017-06-30 Новый экстракт семянок silybum marianum и его применения в дерматологии и лечебно-косметических средствах для кожи
ARP170101827A AR108935A1 (es) 2016-07-01 2017-06-30 Extracto de aquenio de silybum marianum y sus usos en dermatología y dermocosmética
JP2018568390A JP7233222B2 (ja) 2016-07-01 2017-06-30 新規なマリアアザミ痩果抽出物および皮膚科学およびデルモコスメティクスにおけるその使用
US16/313,835 US11285185B2 (en) 2016-07-01 2017-06-30 Methods for treating in dermatology and dermo-cosmetics by administering Silybum marianum achene extract
PT177343357T PT3478309T (pt) 2016-07-01 2017-06-30 Novo extrato de silybum marianum de aquénio e suas utilizações em dermatologia e dermo-cosmética
AU2017291242A AU2017291242B2 (en) 2016-07-01 2017-06-30 Novel Silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics
PL17734335T PL3478309T3 (pl) 2016-07-01 2017-06-30 Nowy ekstrakt z niełupki silybum marianum oraz jego zastosowania w dermatologii i dermokosmetyce
PCT/EP2017/066349 WO2018002338A1 (en) 2016-07-01 2017-06-30 Novel silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics
BR112018076465-5A BR112018076465B1 (pt) 2016-07-01 2017-06-30 Uso de um extrato de aquênio de silybum marianum
ES17734335T ES2882493T3 (es) 2016-07-01 2017-06-30 Nuevo extracto de aquenio Silybum marianum y utilizaciones del mismo en dermatología y dermocosméticos
KR1020187037981A KR102459649B1 (ko) 2016-07-01 2017-06-30 신규한 흰무늬엉겅퀴 수과 추출물 및 피부과 및 피부 화장료에서 이의 용도
CA3028025A CA3028025C (en) 2016-07-01 2017-06-30 Novel silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics
DK17734335.7T DK3478309T3 (da) 2016-07-01 2017-06-30 Nyt silybum-marianum-achene-ekstrakt og anvendelser deraf inden for dermatologi og dermo-kosmetik
SG11201811246RA SG11201811246RA (en) 2016-07-01 2017-06-30 Novel silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics
CL2018003827A CL2018003827A1 (es) 2016-07-01 2018-12-27 Nuevo extracto de aquenio silybum marianum y usos del mismo en la dermatología y dermocosméticos.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1656328A FR3053253B1 (fr) 2016-07-01 2016-07-01 Nouvel extrait d'akenes de silybum marianum et ses utilisations en dermatologie et dermo-cosmetique
FR1656328 2016-07-01

Publications (2)

Publication Number Publication Date
FR3053253A1 FR3053253A1 (fr) 2018-01-05
FR3053253B1 true FR3053253B1 (fr) 2020-01-17

Family

ID=56855709

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1656328A Active FR3053253B1 (fr) 2016-07-01 2016-07-01 Nouvel extrait d'akenes de silybum marianum et ses utilisations en dermatologie et dermo-cosmetique

Country Status (19)

Country Link
US (1) US11285185B2 (enExample)
EP (1) EP3478309B1 (enExample)
JP (1) JP7233222B2 (enExample)
KR (1) KR102459649B1 (enExample)
CN (1) CN109414466B (enExample)
AR (1) AR108935A1 (enExample)
AU (1) AU2017291242B2 (enExample)
BR (1) BR112018076465B1 (enExample)
CL (1) CL2018003827A1 (enExample)
DK (1) DK3478309T3 (enExample)
ES (1) ES2882493T3 (enExample)
FR (1) FR3053253B1 (enExample)
MX (1) MX394161B (enExample)
PL (1) PL3478309T3 (enExample)
PT (1) PT3478309T (enExample)
RU (1) RU2746724C2 (enExample)
SG (1) SG11201811246RA (enExample)
TW (1) TWI773676B (enExample)
WO (1) WO2018002338A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6889732B2 (ja) * 2016-12-07 2021-06-18 キッコーマン株式会社 ヒアルロン酸産生促進剤、及び化粧料
FR3099699B1 (fr) 2019-08-06 2025-09-26 Fabre Pierre Dermo Cosmetique Extrait d’akènes de Silybum marianum (L.) Gaertn. pour promouvoir la croissance capillaire
FR3113585B1 (fr) * 2020-08-31 2025-11-21 Pierre Fabre Dermo Cosmetique Huile de Silybum marianum (L.) Gaertn. dans le renforcement de la fonction barrière de la peau
US20230330003A1 (en) 2020-10-05 2023-10-19 Clariant International Ltd. Compositions Comprising Silybum Marianum Extract As A Senotherapeutic Agent
FR3142088B1 (fr) 2023-03-28 2026-06-26 BASF BEAUTY CARE SOLUTIONS FRANCE SAS / InstSp Utilisations cosmétiques d’un extrait hydrolysé de tourteau de graines de Silybum marianum
FR3148366A1 (fr) * 2023-05-04 2024-11-08 Pierre Fabre Dermo-Cosmetique Extraits enrichis en oxylipines, issus de Silybum marianum (L.) Gaertn.
FR3151199A1 (fr) 2023-07-21 2025-01-24 Pierre Fabre Dermo-Cosmetique Extrait d’akènes de Silybum marianum (L.) Gaertn. pour le traitement ou la prévention de rougeurs cutanées
CN118717834A (zh) * 2024-06-28 2024-10-01 徐增强 一种用于治疗玫瑰痤疮的组合物

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GB2084569B (en) * 1980-09-29 1984-02-15 Madaus & Co Dr Extraction of silymarin
IT1253431B (it) * 1991-12-02 1995-08-08 Valetudo S R L Preparati farmaceutici per uso topico destinati al trattamento della psoriasi e della dermatite atopica
JP2000169332A (ja) 1998-12-09 2000-06-20 Kanebo Ltd 皮脂分泌抑制剤および皮膚化粧料
US20070059269A1 (en) * 2005-08-17 2007-03-15 L'oreal Administration of 8-hexadecene-1,16-dicarboxylic acid for promoting cohesion of the epidermal horny layer
US7303772B2 (en) * 2005-11-10 2007-12-04 Olalde Rangel Jose Angel Synergistic phytoceutical compositions
US20070196318A1 (en) * 2006-02-22 2007-08-23 Marini Jan L Cosmetic herbal compositions
US8980344B2 (en) * 2007-10-01 2015-03-17 Dennis F. Gross Skin care products containing multiple enhancers
FR2940281B1 (fr) * 2008-12-22 2011-04-01 Fabre Pierre Dermo Cosmetique Ester de diol et d'acide gras polyinsature comme agent anti-acne
JP6039908B2 (ja) * 2012-02-21 2016-12-07 キヤノン株式会社 撮像装置及び撮像装置の制御方法
US20130323228A1 (en) * 2012-05-31 2013-12-05 Mary Kay Inc. Cleansing and anti-acne composition
CN104673486B (zh) * 2015-02-13 2018-07-06 安徽嘉旗粮油工程技术有限公司 一种从水飞蓟饼中同时提取水飞蓟油和水飞蓟素的方法
CN110467348A (zh) 2019-07-26 2019-11-19 江苏恒久玻璃科技发展有限公司 玻璃器皿的制备方法

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RU2018145789A (ru) 2020-08-03
PT3478309T (pt) 2021-08-17
AU2017291242A1 (en) 2019-01-17
CL2018003827A1 (es) 2019-02-22
ES2882493T3 (es) 2021-12-02
DK3478309T3 (da) 2021-07-26
TWI773676B (zh) 2022-08-11
RU2746724C2 (ru) 2021-04-19
BR112018076465B1 (pt) 2022-10-25
KR20190026692A (ko) 2019-03-13
AR108935A1 (es) 2018-10-10
US20190175677A1 (en) 2019-06-13
EP3478309B1 (en) 2021-05-12
TW201805016A (zh) 2018-02-16
BR112018076465A2 (pt) 2019-04-09
CA3028025A1 (en) 2018-01-04
KR102459649B1 (ko) 2022-10-26
MX2018016032A (es) 2019-03-21
FR3053253A1 (fr) 2018-01-05
AU2017291242B2 (en) 2023-07-06
PL3478309T3 (pl) 2021-11-22
CN109414466B (zh) 2021-08-31
CN109414466A (zh) 2019-03-01
JP2019524677A (ja) 2019-09-05
WO2018002338A1 (en) 2018-01-04
RU2018145789A3 (enExample) 2020-10-06
US11285185B2 (en) 2022-03-29
SG11201811246RA (en) 2019-01-30
JP7233222B2 (ja) 2023-03-06
MX394161B (es) 2025-03-24
EP3478309A1 (en) 2019-05-08

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