AU2017291242B2 - Novel Silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics - Google Patents

Novel Silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics Download PDF

Info

Publication number
AU2017291242B2
AU2017291242B2 AU2017291242A AU2017291242A AU2017291242B2 AU 2017291242 B2 AU2017291242 B2 AU 2017291242B2 AU 2017291242 A AU2017291242 A AU 2017291242A AU 2017291242 A AU2017291242 A AU 2017291242A AU 2017291242 B2 AU2017291242 B2 AU 2017291242B2
Authority
AU
Australia
Prior art keywords
extract
weight
silybum marianum
silymarin
gaertn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2017291242A
Other languages
English (en)
Other versions
AU2017291242A1 (en
Inventor
Bernard Fabre
Mathieu LETI
Jean-Hilaire Saurat
Olivier Sorg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Dermo Cosmetique SA
Original Assignee
Pierre Fabre Dermo Cosmetique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Dermo Cosmetique SA filed Critical Pierre Fabre Dermo Cosmetique SA
Publication of AU2017291242A1 publication Critical patent/AU2017291242A1/en
Application granted granted Critical
Publication of AU2017291242B2 publication Critical patent/AU2017291242B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Birds (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2017291242A 2016-07-01 2017-06-30 Novel Silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics Active AU2017291242B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1656328A FR3053253B1 (fr) 2016-07-01 2016-07-01 Nouvel extrait d'akenes de silybum marianum et ses utilisations en dermatologie et dermo-cosmetique
FR1656328 2016-07-01
PCT/EP2017/066349 WO2018002338A1 (en) 2016-07-01 2017-06-30 Novel silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics

Publications (2)

Publication Number Publication Date
AU2017291242A1 AU2017291242A1 (en) 2019-01-17
AU2017291242B2 true AU2017291242B2 (en) 2023-07-06

Family

ID=56855709

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017291242A Active AU2017291242B2 (en) 2016-07-01 2017-06-30 Novel Silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics

Country Status (20)

Country Link
US (1) US11285185B2 (enExample)
EP (1) EP3478309B1 (enExample)
JP (1) JP7233222B2 (enExample)
KR (1) KR102459649B1 (enExample)
CN (1) CN109414466B (enExample)
AR (1) AR108935A1 (enExample)
AU (1) AU2017291242B2 (enExample)
BR (1) BR112018076465B1 (enExample)
CA (1) CA3028025A1 (enExample)
CL (1) CL2018003827A1 (enExample)
DK (1) DK3478309T3 (enExample)
ES (1) ES2882493T3 (enExample)
FR (1) FR3053253B1 (enExample)
MX (1) MX394161B (enExample)
PL (1) PL3478309T3 (enExample)
PT (1) PT3478309T (enExample)
RU (1) RU2746724C2 (enExample)
SG (1) SG11201811246RA (enExample)
TW (1) TWI773676B (enExample)
WO (1) WO2018002338A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6889732B2 (ja) * 2016-12-07 2021-06-18 キッコーマン株式会社 ヒアルロン酸産生促進剤、及び化粧料
FR3099699B1 (fr) 2019-08-06 2025-09-26 Fabre Pierre Dermo Cosmetique Extrait d’akènes de Silybum marianum (L.) Gaertn. pour promouvoir la croissance capillaire
FR3113585B1 (fr) * 2020-08-31 2025-11-21 Pierre Fabre Dermo Cosmetique Huile de Silybum marianum (L.) Gaertn. dans le renforcement de la fonction barrière de la peau
EP4225266A1 (en) 2020-10-05 2023-08-16 Clariant International Ltd Compositions comprising silybum marianum extract as a senotherapeutic agent
FR3142088A1 (fr) 2023-03-28 2024-05-24 BASF BEAUTY CARE SOLUTIONS FRANCE SAS / InstSp Utilisations cosmétiques d’un extrait hydrolysé de tourteau de graines de Silybum marianum
FR3148366A1 (fr) * 2023-05-04 2024-11-08 Pierre Fabre Dermo-Cosmetique Extraits enrichis en oxylipines, issus de Silybum marianum (L.) Gaertn.
FR3151199A1 (fr) 2023-07-21 2025-01-24 Pierre Fabre Dermo-Cosmetique Extrait d’akènes de Silybum marianum (L.) Gaertn. pour le traitement ou la prévention de rougeurs cutanées

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2084569A (en) * 1980-09-29 1982-04-15 Madaus & Co Dr Extraction of Silymarin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253431B (it) * 1991-12-02 1995-08-08 Valetudo S R L Preparati farmaceutici per uso topico destinati al trattamento della psoriasi e della dermatite atopica
JP2000169332A (ja) 1998-12-09 2000-06-20 Kanebo Ltd 皮脂分泌抑制剤および皮膚化粧料
US20070059269A1 (en) * 2005-08-17 2007-03-15 L'oreal Administration of 8-hexadecene-1,16-dicarboxylic acid for promoting cohesion of the epidermal horny layer
US7303772B2 (en) * 2005-11-10 2007-12-04 Olalde Rangel Jose Angel Synergistic phytoceutical compositions
US20070196318A1 (en) * 2006-02-22 2007-08-23 Marini Jan L Cosmetic herbal compositions
WO2009046116A1 (en) * 2007-10-01 2009-04-09 Dennis Gross Skin care products containing multiple enhancers
FR2940281B1 (fr) * 2008-12-22 2011-04-01 Fabre Pierre Dermo Cosmetique Ester de diol et d'acide gras polyinsature comme agent anti-acne
JP6039908B2 (ja) * 2012-02-21 2016-12-07 キヤノン株式会社 撮像装置及び撮像装置の制御方法
US20130323228A1 (en) 2012-05-31 2013-12-05 Mary Kay Inc. Cleansing and anti-acne composition
CN104673486B (zh) * 2015-02-13 2018-07-06 安徽嘉旗粮油工程技术有限公司 一种从水飞蓟饼中同时提取水飞蓟油和水飞蓟素的方法
CN110467348A (zh) * 2019-07-26 2019-11-19 江苏恒久玻璃科技发展有限公司 玻璃器皿的制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2084569A (en) * 1980-09-29 1982-04-15 Madaus & Co Dr Extraction of Silymarin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALVAREZ BARRETO: "EXTRACTION OF SIL YMARIN COMPOUNDS FROM MILK THISTLE (SILYBUM MAR/ANUM) SEED USING HOT LIQUID WATER AS THE SOL VENT '", 1 June 2002 (2002-06-01), XP055348243, Retrieved from the Internet [retrieved on 20170221] *

Also Published As

Publication number Publication date
JP2019524677A (ja) 2019-09-05
CN109414466A (zh) 2019-03-01
RU2018145789A (ru) 2020-08-03
BR112018076465A2 (pt) 2019-04-09
US11285185B2 (en) 2022-03-29
MX2018016032A (es) 2019-03-21
RU2746724C2 (ru) 2021-04-19
FR3053253B1 (fr) 2020-01-17
EP3478309A1 (en) 2019-05-08
CN109414466B (zh) 2021-08-31
CA3028025A1 (en) 2018-01-04
JP7233222B2 (ja) 2023-03-06
KR20190026692A (ko) 2019-03-13
AU2017291242A1 (en) 2019-01-17
KR102459649B1 (ko) 2022-10-26
EP3478309B1 (en) 2021-05-12
PT3478309T (pt) 2021-08-17
PL3478309T3 (pl) 2021-11-22
US20190175677A1 (en) 2019-06-13
FR3053253A1 (fr) 2018-01-05
SG11201811246RA (en) 2019-01-30
TWI773676B (zh) 2022-08-11
ES2882493T3 (es) 2021-12-02
WO2018002338A1 (en) 2018-01-04
TW201805016A (zh) 2018-02-16
DK3478309T3 (da) 2021-07-26
RU2018145789A3 (enExample) 2020-10-06
MX394161B (es) 2025-03-24
CL2018003827A1 (es) 2019-02-22
AR108935A1 (es) 2018-10-10
BR112018076465B1 (pt) 2022-10-25

Similar Documents

Publication Publication Date Title
AU2017291242B2 (en) Novel Silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics
EP2030626B1 (en) Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds
ES2975069T3 (es) Combinación de un retinoide y un extracto de Silybum marianum (L.) Gaertn
US20210236574A1 (en) Passion flower seed extract, and cosmetic, pharmaceutical or dermatological compositions containing same
JP2013035795A (ja) 新規フェニルエタノイド配糖体及び皮膚化粧料
KR20100107856A (ko) 안정화된 옥수수겨 추출물의 나노리포좀을 함유하는 화장료조성물
HK40004167B (zh) 新的水飞蓟瘦果提取物及其在皮肤病学和皮肤化妆品中的用途
HK40004167A (en) Novel silybum marianum achene extract and uses thereof in dermatology and dermo-cosmetics
KR102882993B1 (ko) 생달나무 추출물을 유효성분으로 포함하는 주름개선용 화장료 조성물
De Carli et al. Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in mice
KR20180098000A (ko) 피부 미용액을 이용한 화장료 조성물의 제조방법
JP2024019760A (ja) 皮脂中ビタミンｅ増加剤
JPH11158031A (ja) 皮膚外用剤
WO2022149144A1 (en) Stable efficient cosmetic preparations
KR102472093B1 (ko) 피부 개선용 조성물
RS20230775A1 (sr) Liposomski preparati za topikalnu primenu kod osoba sa hiperglikemijom
BR112020011661B1 (pt) Combinação de um retinoide e um extrato de silybum marianum (l.) gaertn., composição dermatológica ou dermocosmética compreendendo a dita combinação e seus usos
JPH1160479A (ja) 痩身剤
HK40030418B (en) Combination of a retinoid and an extract of silybum marianum (l.) gaertn

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)