FR2752841B1 - Procede de preparation de l'acide 3-amino-1-hydroxypropane- 1,1-diphosphonique - Google Patents
Procede de preparation de l'acide 3-amino-1-hydroxypropane- 1,1-diphosphoniqueInfo
- Publication number
- FR2752841B1 FR2752841B1 FR9710351A FR9710351A FR2752841B1 FR 2752841 B1 FR2752841 B1 FR 2752841B1 FR 9710351 A FR9710351 A FR 9710351A FR 9710351 A FR9710351 A FR 9710351A FR 2752841 B1 FR2752841 B1 FR 2752841B1
- Authority
- FR
- France
- Prior art keywords
- amino
- diphosphonic acid
- hydroxypropane
- preparation
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 title abstract 3
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 1
- 229940000635 beta-alanine Drugs 0.000 abstract 1
- 239000007810 chemical reaction solvent Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000005191 phase separation Methods 0.000 abstract 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008096 xylene Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention a pour objet un procédé de préparation de l'acide 3-amino-1-hydroxy-propane-1,1-diphosphonique qui comprend les étapes consistant à : mélanger une N-alcoxycarbonyl-bêta-alanine, du chlorure phosphoreux et de l'acide phosphoreux dans le rapport de 1 : 1 : 1 à 1 : 3 : 3 dans le xylène comme solvant de réaction, à 70 - 140 deg.C; hydrolyser; et obtenir par séparation de phases l'acide 3-amino-1-hydroxypropane-1,1-diphosphonique en tant que produit.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019960037983A KR100192215B1 (ko) | 1996-09-03 | 1996-09-03 | 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2752841A1 FR2752841A1 (fr) | 1998-03-06 |
FR2752841B1 true FR2752841B1 (fr) | 1999-12-24 |
Family
ID=19472584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9710351A Expired - Fee Related FR2752841B1 (fr) | 1996-09-03 | 1997-08-13 | Procede de preparation de l'acide 3-amino-1-hydroxypropane- 1,1-diphosphonique |
Country Status (11)
Country | Link |
---|---|
US (1) | US5792885A (fr) |
JP (1) | JP2841295B2 (fr) |
KR (1) | KR100192215B1 (fr) |
CN (1) | CN1064366C (fr) |
BR (1) | BR9704595A (fr) |
CA (1) | CA2212313A1 (fr) |
DE (1) | DE19737923A1 (fr) |
ES (1) | ES2138539B1 (fr) |
FR (1) | FR2752841B1 (fr) |
GB (1) | GB2316945B (fr) |
IT (1) | IT1294370B1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US7008645B2 (en) * | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
IL125336A0 (en) | 1998-07-14 | 1999-03-12 | Yissum Res Dev Co | Compositions for inhibition and treatment of restinosis |
US6984400B2 (en) * | 1998-07-14 | 2006-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating restenosis using bisphosphonate nanoparticles |
PE20011061A1 (es) | 2000-02-01 | 2001-11-20 | Procter & Gamble | Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato |
PE20011065A1 (es) | 2000-02-01 | 2001-11-21 | Procter & Gamble | Proceso para fabricar bisfosfonatos geminales |
ITMI20020908A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
JP3857706B2 (ja) * | 2002-05-17 | 2006-12-13 | テバ ファーマシューティカル インダストリーズ リミティド | ビスホスホン酸作製のための特定の希釈剤の使用 |
US20060051407A1 (en) * | 2003-06-27 | 2006-03-09 | Yoram Richter | Method of treating ischemia-reperfusion injury |
US10517883B2 (en) * | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
WO2006134603A1 (fr) * | 2005-06-13 | 2006-12-21 | Jubilant Organosys Limited | Procédé de production d’acides bisphosphoniques et de formes de ceux-ci |
CA2642321A1 (fr) * | 2006-02-20 | 2007-08-30 | Alembic Limited | Procede ameliore de fabrication de derives biphosphoniques |
US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
CN106179235A (zh) * | 2016-08-29 | 2016-12-07 | 江苏海普功能材料有限公司 | 一种除化学镍吸附剂及其制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2130794C3 (de) * | 1971-06-22 | 1974-07-11 | Joh. A. Benckiser Gmbh, 6700 Ludwigshafen | Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure |
DE2943498C2 (de) * | 1979-10-27 | 1983-01-27 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure |
DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
DE3540150A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
-
1996
- 1996-09-03 KR KR1019960037983A patent/KR100192215B1/ko not_active IP Right Cessation
-
1997
- 1997-08-05 CA CA002212313A patent/CA2212313A1/fr not_active Abandoned
- 1997-08-13 FR FR9710351A patent/FR2752841B1/fr not_active Expired - Fee Related
- 1997-08-13 US US08/910,851 patent/US5792885A/en not_active Expired - Fee Related
- 1997-08-25 ES ES009701836A patent/ES2138539B1/es not_active Expired - Lifetime
- 1997-08-27 DE DE19737923A patent/DE19737923A1/de not_active Withdrawn
- 1997-08-29 IT IT97MI001989A patent/IT1294370B1/it active IP Right Grant
- 1997-09-01 CN CN97116850A patent/CN1064366C/zh not_active Expired - Fee Related
- 1997-09-01 JP JP9235518A patent/JP2841295B2/ja not_active Expired - Lifetime
- 1997-09-03 BR BR9704595A patent/BR9704595A/pt not_active Application Discontinuation
- 1997-09-03 GB GB9718725A patent/GB2316945B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IT1294370B1 (it) | 1999-03-24 |
KR19980019751A (ko) | 1998-06-25 |
DE19737923A1 (de) | 1998-03-05 |
JP2841295B2 (ja) | 1998-12-24 |
KR100192215B1 (ko) | 1999-06-15 |
MX9706430A (es) | 1998-07-31 |
ES2138539B1 (es) | 2000-09-16 |
ITMI971989A1 (it) | 1999-03-01 |
GB9718725D0 (en) | 1997-11-12 |
GB2316945A (en) | 1998-03-11 |
CN1175582A (zh) | 1998-03-11 |
GB2316945A8 (en) | 1998-09-02 |
CA2212313A1 (fr) | 1998-03-03 |
GB2316945B (en) | 2000-07-05 |
JPH10101685A (ja) | 1998-04-21 |
ES2138539A1 (es) | 2000-01-01 |
BR9704595A (pt) | 1998-10-27 |
US5792885A (en) | 1998-08-11 |
CN1064366C (zh) | 2001-04-11 |
FR2752841A1 (fr) | 1998-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |