FR2716881B1 - Procédé de préparation et de purification d'Iopamidol. - Google Patents

Procédé de préparation et de purification d'Iopamidol.

Info

Publication number
FR2716881B1
FR2716881B1 FR9502242A FR9502242A FR2716881B1 FR 2716881 B1 FR2716881 B1 FR 2716881B1 FR 9502242 A FR9502242 A FR 9502242A FR 9502242 A FR9502242 A FR 9502242A FR 2716881 B1 FR2716881 B1 FR 2716881B1
Authority
FR
France
Prior art keywords
iopamidol
purification
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9502242A
Other languages
English (en)
Other versions
FR2716881A1 (fr
Inventor
Vincenzo Cannata
Valeriano Merli
Santo Claudio Dal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Publication of FR2716881A1 publication Critical patent/FR2716881A1/fr
Application granted granted Critical
Publication of FR2716881B1 publication Critical patent/FR2716881B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
FR9502242A 1994-03-03 1995-02-27 Procédé de préparation et de purification d'Iopamidol. Expired - Lifetime FR2716881B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940378A IT1274027B (it) 1994-03-03 1994-03-03 Processo per la preparazione e purificazione di mezzi di contrasto iodurati

Publications (2)

Publication Number Publication Date
FR2716881A1 FR2716881A1 (fr) 1995-09-08
FR2716881B1 true FR2716881B1 (fr) 1996-08-02

Family

ID=11368040

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9502242A Expired - Lifetime FR2716881B1 (fr) 1994-03-03 1995-02-27 Procédé de préparation et de purification d'Iopamidol.

Country Status (22)

Country Link
US (1) US5550287A (fr)
JP (1) JP4143136B2 (fr)
AT (1) AT405052B (fr)
BE (1) BE1007938A3 (fr)
CA (1) CA2143805C (fr)
CH (1) CH689296A5 (fr)
CZ (1) CZ287640B6 (fr)
DE (1) DE19507294B4 (fr)
DK (1) DK171530B1 (fr)
ES (1) ES2105961B1 (fr)
FI (1) FI950977A (fr)
FR (1) FR2716881B1 (fr)
GB (1) GB2287024B (fr)
HU (1) HU216330B (fr)
IE (1) IE950154A1 (fr)
IL (1) IL112718A (fr)
IT (1) IT1274027B (fr)
NL (1) NL194332C (fr)
NO (1) NO304112B1 (fr)
PT (1) PT101665B (fr)
SE (1) SE510124C2 (fr)
ZA (1) ZA951748B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2929236A (en) * 1955-03-29 1960-03-22 Steward Construction Company Building wall construction
DE69606601T2 (de) * 1995-05-23 2000-07-06 Fructamine Spa Verfahren zur herstellung von dicarbonsäure-dichlorid
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
ES2162117T3 (es) * 1995-12-01 2001-12-16 Mallinckrodt Med Imaging Ie Procedimiento cromatografico en fase inversa.
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1292127B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la dissalazione di sostanze instabili a ph acidi
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
US20110017673A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Endotoxin removal in contrast media
IT1403988B1 (it) * 2010-07-15 2013-11-08 Bracco Imaging Spa Processo per la preparazione di agenti di contrasto.
EP3066071B1 (fr) 2013-11-05 2018-04-18 Bracco Imaging S.p.A Procédé de préparation d'iopamidol
CN115403481A (zh) * 2022-04-13 2022-11-29 江苏宇田医药有限公司 一种通过离子交换树脂纯化碘海醇的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4956989A (fr) * 1972-10-09 1974-06-03
CH608189A5 (fr) * 1974-12-13 1978-12-29 Savac Ag
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
ATE79368T1 (de) * 1987-05-22 1992-08-15 Bracco Spa Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.
JPH03244380A (ja) * 1990-02-23 1991-10-31 Asahi Chem Ind Co Ltd 精製酵素およびその製造方法
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IT1254991B (it) * 1992-06-24 1995-10-11 Chemi Spa Procedimento per la preparazione di glicerofosfolipidi
DE10204861B4 (de) * 2002-02-06 2004-01-29 Wacker Construction Equipment Ag Luftfederschlagwerk mit elektrodynamisch bewegtem Antriebskolben

Also Published As

Publication number Publication date
DK171530B1 (da) 1996-12-23
SE9500752L (sv) 1995-09-04
NL194332B (nl) 2001-09-03
CZ287640B6 (en) 2001-01-17
DE19507294A1 (de) 1995-09-07
IE950154A1 (en) 1995-09-06
HU9500645D0 (en) 1995-04-28
DK21795A (da) 1995-09-04
NL194332C (nl) 2002-01-04
FR2716881A1 (fr) 1995-09-08
NO950814D0 (no) 1995-03-02
FI950977A (fi) 1995-09-04
IL112718A0 (en) 1995-05-26
DE19507294B4 (de) 2005-12-15
NO950814L (no) 1995-09-04
GB9503893D0 (en) 1995-04-19
HU216330B (hu) 1999-06-28
CA2143805C (fr) 2004-12-28
GB2287024B (en) 1998-07-08
IT1274027B (it) 1997-07-14
GB2287024A (en) 1995-09-06
CZ56295A3 (en) 1995-11-15
US5550287A (en) 1996-08-27
SE510124C2 (sv) 1999-04-19
ITMI940378A1 (it) 1995-09-04
FI950977A0 (fi) 1995-03-02
JP4143136B2 (ja) 2008-09-03
PT101665B (pt) 1999-01-29
PT101665A (pt) 1995-09-12
BE1007938A3 (fr) 1995-11-21
ES2105961B1 (es) 1998-07-01
NL9500415A (nl) 1995-10-02
ITMI940378A0 (it) 1994-03-03
ES2105961A1 (es) 1997-10-16
CH689296A5 (it) 1999-02-15
SE9500752D0 (sv) 1995-03-02
ATA36995A (de) 1998-09-15
HUT70401A (en) 1995-10-30
JPH07278081A (ja) 1995-10-24
ZA951748B (en) 1995-12-08
AT405052B (de) 1999-05-25
IL112718A (en) 1999-05-09
CA2143805A1 (fr) 1995-09-04
NO304112B1 (no) 1998-10-26

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