ES2105961A1 - Procedimiento para la preparacion y purificacion de agentes de contraste yodados. - Google Patents
Procedimiento para la preparacion y purificacion de agentes de contraste yodados.Info
- Publication number
- ES2105961A1 ES2105961A1 ES09500394A ES9500394A ES2105961A1 ES 2105961 A1 ES2105961 A1 ES 2105961A1 ES 09500394 A ES09500394 A ES 09500394A ES 9500394 A ES9500394 A ES 9500394A ES 2105961 A1 ES2105961 A1 ES 2105961A1
- Authority
- ES
- Spain
- Prior art keywords
- purification
- preparation
- contrast agents
- iodinated contrast
- iodinated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION Y PURIFICACION DE AGENTES DE CONTRASTE YODADOS, QUE CONSISTE EN CARGAR UNA SOLUCION DE BIS- (1,2-DIHIDROXIPROPILAMIDA) DEL ACIDO L-5- (2-ACOTOXIPROPIONILAMINO) -2,4, O-TRIYODOISOFTALICO EN UNA COLUMNA QUE CONTIENE UNA RESINA ANIONICA FUERTE, DILUIR CON AGUA, ELUIR POSTERIORMENTE CON UNA SOLUCION ACUOSA DILUIDA DE UN ACIDO DEBIL, DE MODO QUE SE LIBERE DE LA COLUMNA BIS- (1,3-DIHIDROXIPROPILAMIDA) DEL ACIDO L-5- (2-HIDROXIPROPIONILAMINO)-2,4, OTRIYODOISOFTALICO, Y PURIFICACION FINAL DEL PRODUCTO CRUDO RESULTANTE MEDIANTE CROMATOGRAFIA SOBRE UNA RESINA ANIONICA DEBIL. EL PROCEDIMIENTO SE UTILIZA PARA LA PREPARACION Y PURIFICACION DE AGENTES DE CONTRASTE YODADOS PARA RAYOS X.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI940378A IT1274027B (it) | 1994-03-03 | 1994-03-03 | Processo per la preparazione e purificazione di mezzi di contrasto iodurati |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2105961A1 true ES2105961A1 (es) | 1997-10-16 |
ES2105961B1 ES2105961B1 (es) | 1998-07-01 |
Family
ID=11368040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09500394A Expired - Fee Related ES2105961B1 (es) | 1994-03-03 | 1995-03-01 | Procedimiento para la preparacion y purificacion de agentes de contraste yodados. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5550287A (es) |
JP (1) | JP4143136B2 (es) |
AT (1) | AT405052B (es) |
BE (1) | BE1007938A3 (es) |
CA (1) | CA2143805C (es) |
CH (1) | CH689296A5 (es) |
CZ (1) | CZ287640B6 (es) |
DE (1) | DE19507294B4 (es) |
DK (1) | DK171530B1 (es) |
ES (1) | ES2105961B1 (es) |
FI (1) | FI950977A (es) |
FR (1) | FR2716881B1 (es) |
GB (1) | GB2287024B (es) |
HU (1) | HU216330B (es) |
IE (1) | IE950154A1 (es) |
IL (1) | IL112718A (es) |
IT (1) | IT1274027B (es) |
NL (1) | NL194332C (es) |
NO (1) | NO304112B1 (es) |
PT (1) | PT101665B (es) |
SE (1) | SE510124C2 (es) |
ZA (1) | ZA951748B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2929236A (en) * | 1955-03-29 | 1960-03-22 | Steward Construction Company | Building wall construction |
CN1068582C (zh) * | 1995-05-23 | 2001-07-18 | 弗鲁克泰明公司 | 制备二酰氯的方法 |
PT101720A (pt) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | Processo para a purificacao e cristalizacao de iopamidol |
WO1997020609A1 (en) * | 1995-12-01 | 1997-06-12 | Mallinckrodt Medical Imaging-Ireland | Reversed phase chromatographic process |
IT1283319B1 (it) * | 1996-03-29 | 1998-04-16 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
IT1289519B1 (it) * | 1996-12-24 | 1998-10-15 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
IT1292127B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la dissalazione di sostanze instabili a ph acidi |
DE19736472C1 (de) * | 1997-08-21 | 1999-04-22 | Bernhard Dr Sixt | Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln |
US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
US6803485B2 (en) * | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
TWI288654B (en) * | 2001-05-17 | 2007-10-21 | Ind Tech Res Inst | Process for the purification of water-soluble non-ionic contrast agents |
US20110017673A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Endotoxin removal in contrast media |
IT1403988B1 (it) * | 2010-07-15 | 2013-11-08 | Bracco Imaging Spa | Processo per la preparazione di agenti di contrasto. |
MX2016005829A (es) | 2013-11-05 | 2017-03-10 | Bracco Imaging Spa | Procedimiento para la preparacion de iopamidol. |
CN115403481A (zh) * | 2022-04-13 | 2022-11-29 | 江苏宇田医药有限公司 | 一种通过离子交换树脂纯化碘海醇的方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4956989A (es) * | 1972-10-09 | 1974-06-03 | ||
GB1472050A (en) * | 1974-12-13 | 1977-04-27 | Savac Ag | Non-ionic x-ray contrast agents |
US4348377A (en) * | 1979-08-09 | 1982-09-07 | Bracco Industria Chimica S.P.A. | New derivatives of 2,4,6-triiodo-isophthalic acid, proceses for their synthesis and X-ray contrasting materials containing these |
US5066823A (en) * | 1987-05-22 | 1991-11-19 | Bracco Industria Chemica S.P.A. | Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives |
WO1992009562A1 (en) * | 1990-11-21 | 1992-06-11 | Mallinckrodt Medical, Inc. | Novel x-ray contrast agents, compositions and methods |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
JPH03244380A (ja) * | 1990-02-23 | 1991-10-31 | Asahi Chem Ind Co Ltd | 精製酵素およびその製造方法 |
IT1248741B (it) * | 1991-02-26 | 1995-01-26 | Bracco Spa | Processo di concentrazione e di purificazione di composti organici |
IT1254991B (it) * | 1992-06-24 | 1995-10-11 | Chemi Spa | Procedimento per la preparazione di glicerofosfolipidi |
DE10204861B4 (de) * | 2002-02-06 | 2004-01-29 | Wacker Construction Equipment Ag | Luftfederschlagwerk mit elektrodynamisch bewegtem Antriebskolben |
-
1994
- 1994-03-03 IT ITMI940378A patent/IT1274027B/it active IP Right Grant
-
1995
- 1995-02-21 IL IL11271895A patent/IL112718A/xx not_active IP Right Cessation
- 1995-02-24 IE IE950154A patent/IE950154A1/en not_active IP Right Cessation
- 1995-02-27 FR FR9502242A patent/FR2716881B1/fr not_active Expired - Lifetime
- 1995-02-27 GB GB9503893A patent/GB2287024B/en not_active Expired - Lifetime
- 1995-03-01 ES ES09500394A patent/ES2105961B1/es not_active Expired - Fee Related
- 1995-03-01 AT AT0036995A patent/AT405052B/de not_active IP Right Cessation
- 1995-03-01 PT PT101665A patent/PT101665B/pt not_active IP Right Cessation
- 1995-03-02 ZA ZA951748A patent/ZA951748B/xx unknown
- 1995-03-02 BE BE9500182A patent/BE1007938A3/fr not_active IP Right Cessation
- 1995-03-02 NO NO950814A patent/NO304112B1/no not_active IP Right Cessation
- 1995-03-02 DE DE19507294A patent/DE19507294B4/de not_active Expired - Lifetime
- 1995-03-02 CA CA002143805A patent/CA2143805C/en not_active Expired - Lifetime
- 1995-03-02 FI FI950977A patent/FI950977A/fi not_active Application Discontinuation
- 1995-03-02 NL NL9500415A patent/NL194332C/nl not_active IP Right Cessation
- 1995-03-02 HU HU9500645A patent/HU216330B/hu unknown
- 1995-03-02 DK DK021795A patent/DK171530B1/da not_active IP Right Cessation
- 1995-03-02 SE SE9500752A patent/SE510124C2/sv not_active IP Right Cessation
- 1995-03-02 CH CH00594/95A patent/CH689296A5/it not_active IP Right Cessation
- 1995-03-03 US US08/397,955 patent/US5550287A/en not_active Expired - Lifetime
- 1995-03-03 JP JP04386495A patent/JP4143136B2/ja not_active Expired - Lifetime
- 1995-03-03 CZ CZ1995562A patent/CZ287640B6/cs not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4956989A (es) * | 1972-10-09 | 1974-06-03 | ||
GB1472050A (en) * | 1974-12-13 | 1977-04-27 | Savac Ag | Non-ionic x-ray contrast agents |
US4348377A (en) * | 1979-08-09 | 1982-09-07 | Bracco Industria Chimica S.P.A. | New derivatives of 2,4,6-triiodo-isophthalic acid, proceses for their synthesis and X-ray contrasting materials containing these |
US5066823A (en) * | 1987-05-22 | 1991-11-19 | Bracco Industria Chemica S.P.A. | Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives |
WO1992009562A1 (en) * | 1990-11-21 | 1992-06-11 | Mallinckrodt Medical, Inc. | Novel x-ray contrast agents, compositions and methods |
Non-Patent Citations (2)
Title |
---|
DERWENT ABSTRACT N 65409V, Semana V37 & JP 49056989 A (KYOWA HAKKO KOGYO Co. Ltd) 1974 * |
REED, L.A. y col. Catalytic Diacylation of Sugars with Strong Base Ion-exchange Resins; an Alternative to the ZemplÚn Procedure. J.C.S. CHEM. COMM., 1981, pßginas 760-761 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2105961A1 (es) | Procedimiento para la preparacion y purificacion de agentes de contraste yodados. | |
HK1023566A1 (en) | Process to prepare tolterodine | |
MY121543A (en) | Preparation of 3,4,4-trisubstituted-piperidinyl-n- alkylcarboxylates and intermediates | |
HU9303030D0 (en) | Process for preparation of l-5-(2-acetoxi-propionyl-amino)-2,4,6-trijodo-dichloro-isophtalic acid | |
HUP9700189A3 (en) | Process for producing 5-amino-2,4,6-triiode-1,3-benzenedicarboxylic acid | |
FR2721598B1 (fr) | Procédé de préparation de catalyseurs d'ammoxydation. | |
BG101894A (en) | 4-aminoteirahydrobenzisoxazole or -isothiazole compounds | |
EP0692476A3 (de) | Verbessertes Verfahren zur Herstellung von N,N'-Carbonyldiazolen, insbesondere N,N'-Carbonyldiimidazol | |
FR2714666B1 (fr) | Procédé d'élimination d'effluents aqueux comprenant notamment des composés hydroxynitroaromatiques. | |
IL120483A (en) | Process for the preparation of (S)-N-N'-bis¬2-hydroxy-1-hydroxymethyl)ethyl¾-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalamide | |
GB9710726D0 (en) | Compound | |
FR2697249B1 (fr) | Procédé de préparation du bis(1,3-dihydroxypropylamide) d'acide L-5-(2-acétoxypropionylamino)-2,4,6-triiodo-isophtalique. | |
HUT49846A (en) | Process for producing n-(3',4'-dimethoxycinnamoyl)-anthranilic acid (tranilast) | |
EG16124A (en) | (2-(nitropyridinyl)amino)phenyl)arylemethanones in a process for preparing pyrido(1,4)benzodiazepina | |
MD970146A (en) | Process for R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-il)methil]pyridine, a central nervous system agent A process for R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-il)methil]pyridine by a novel synthesis is described where 5-oxo-3-phenil-3-cyclohexene-carboxylic acid is converted | |
MX9605668A (es) | Sal de estilbazolio, su preparacion y uso. | |
HU9500321D0 (en) | Process for the preparation of 2,2'-dimorpholino-diethylether by reducing, catalytic amination of diethyleneglycol by morpholine | |
IT1265456B1 (it) | Processo per la purificazione di composti organici | |
FR2668141B1 (fr) | Procede de purification d'eaux residuaires produites lors de la preparation de tio2, et procede de preparation de tio2 mettant en óoeuvre un tel procede de purification. | |
TW257817B (en) | Process of producing wetstrength agent | |
IL108963A0 (en) | Process for the preparation of 3,4' - diaminodiphenyl ether | |
HU9403141D0 (en) | New process for producing 2-phenyl-3,3,3-trifluoro-propionic acid | |
FR2721020B1 (fr) | Procédé de préparation d'alpha-amino-aldéhydes N-protégés. | |
FR11C0012I2 (fr) | Procede de preparation d'un concentre d'inhibiteur de la c1-esterase (c1-inh), et concentre obtenu, a usage therapeutique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19971016 Kind code of ref document: A1 Effective date: 19971016 |
|
PC2A | Transfer of patent | ||
FD2A | Announcement of lapse in spain |
Effective date: 20150826 |