FR2684672A1 - Derives de pyrimidine, utiles pour le traitement d'etats tels que l'hypertension et l'insuffisance cardiaque, et procede pour leur preparation. - Google Patents

Derives de pyrimidine, utiles pour le traitement d'etats tels que l'hypertension et l'insuffisance cardiaque, et procede pour leur preparation. Download PDF

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Publication number
FR2684672A1
FR2684672A1 FR9214376A FR9214376A FR2684672A1 FR 2684672 A1 FR2684672 A1 FR 2684672A1 FR 9214376 A FR9214376 A FR 9214376A FR 9214376 A FR9214376 A FR 9214376A FR 2684672 A1 FR2684672 A1 FR 2684672A1
Authority
FR
France
Prior art keywords
group
alkyl
formula
alkoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR9214376A
Other languages
English (en)
French (fr)
Inventor
Edwards Martin Paul
Ratcliffe Arnold Harry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of FR2684672A1 publication Critical patent/FR2684672A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR9214376A 1991-12-04 1992-11-30 Derives de pyrimidine, utiles pour le traitement d'etats tels que l'hypertension et l'insuffisance cardiaque, et procede pour leur preparation. Pending FR2684672A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919125842A GB9125842D0 (en) 1991-12-04 1991-12-04 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
FR2684672A1 true FR2684672A1 (fr) 1993-06-11

Family

ID=10705730

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9214376A Pending FR2684672A1 (fr) 1991-12-04 1992-11-30 Derives de pyrimidine, utiles pour le traitement d'etats tels que l'hypertension et l'insuffisance cardiaque, et procede pour leur preparation.

Country Status (10)

Country Link
JP (1) JPH05255327A (enExample)
BE (1) BE1005473A3 (enExample)
CA (1) CA2082668A1 (enExample)
DE (1) DE4239440A1 (enExample)
FR (1) FR2684672A1 (enExample)
GB (2) GB9125842D0 (enExample)
IE (1) IE922785A1 (enExample)
IT (1) IT1256320B (enExample)
NL (1) NL9202091A (enExample)
ZA (1) ZA928742B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439911A (en) * 1992-12-28 1995-08-08 Shionogi & Co., Ltd. Aminopyrimidine derivatives and their production and use
ES2126061T3 (es) * 1993-03-24 1999-03-16 American Home Prod Piridopirimidinas substituidas como antihipertensores.
KR100300566B1 (ko) * 1994-09-17 2001-11-22 조생현 피리미디논유도체와그의제조방법및용도
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
JP5154728B2 (ja) 2000-07-24 2013-02-27 クレニツキー・ファーマシューティカルズ，インコーポレイテッド 神経栄養活性を有する置換５−アルキニルピリミジン
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
ES2257616T3 (es) * 2003-04-25 2006-08-01 Actimis Pharmaceuticals, Inc. Derivados del acido pirimidinilacetico utiles para el tratamiento de enfermedades mediadas por crth2.
WO2005073234A2 (en) 2004-01-31 2005-08-11 Actimis Pharmaceuticals, Inc. Imidazo[1,2-c]pyrimidinylacetic acid derivatives
CL2008002827A1 (es) 2007-09-25 2009-11-27 Actimis Pharmaceuticals Inc Compuestos derivados de 2-s-bencil pirimidina, antagonistas del receptor crth2; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades alergicas mediadas por eosinofilos y basofilos, tales como asma, rinitis alergica, dermatitis atopica, conjuntivitis alergica, sinusitis y psoriasis, entre otras
ES2383249T3 (es) 2007-09-25 2012-06-19 Actimis Pharmaceuticals, Inc. Alquiltiopirimidinas como antagonistas de CRTH2
KR102481705B1 (ko) * 2020-08-04 2022-12-27 연세대학교 산학협력단 트리아졸 유도체를 유효성분으로 포함하는 간 섬유증의 예방 또는 치료용 조성물
TW202304933A (zh) * 2021-04-09 2023-02-01 大陸商海南耀臻生物醫藥科技有限公司 泛素特異性蛋白酶１（ｕｓｐ１）抑制劑、藥物組合物及其治療哺乳動物由ｕｓｐ１介導的疾病的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424317A2 (de) * 1989-10-19 1991-04-24 Ciba-Geigy Ag Pyrimidine
EP0475206A2 (en) * 1990-09-10 1992-03-18 Abbott Laboratories Angiotensin II receptor antagonists
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0424317A2 (de) * 1989-10-19 1991-04-24 Ciba-Geigy Ag Pyrimidine
EP0475206A2 (en) * 1990-09-10 1992-03-18 Abbott Laboratories Angiotensin II receptor antagonists
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
DE4239440A1 (enExample) 1993-06-09
ITMI922661A0 (it) 1992-11-20
BE1005473A3 (fr) 1993-08-03
ITMI922661A1 (it) 1994-05-20
GB2262096A (en) 1993-06-09
GB9225283D0 (en) 1993-01-27
IT1256320B (it) 1995-11-30
JPH05255327A (ja) 1993-10-05
CA2082668A1 (en) 1993-06-05
IE922785A1 (en) 1993-06-16
ZA928742B (en) 1993-06-09
GB9125842D0 (en) 1992-02-05
NL9202091A (nl) 1993-07-01

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