FR2656220B1 - Agents bloquants de l'effet ou de la formation du facteur edrf pour le traitement des chocs. - Google Patents

Agents bloquants de l'effet ou de la formation du facteur edrf pour le traitement des chocs.

Info

Publication number
FR2656220B1
FR2656220B1 FR9015904A FR9015904A FR2656220B1 FR 2656220 B1 FR2656220 B1 FR 2656220B1 FR 9015904 A FR9015904 A FR 9015904A FR 9015904 A FR9015904 A FR 9015904A FR 2656220 B1 FR2656220 B1 FR 2656220B1
Authority
FR
France
Prior art keywords
edrf
shock
factor
formation
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9015904A
Other languages
English (en)
Other versions
FR2656220A1 (fr
Inventor
Pierre Braquet
Pierre-Etienne Chabrier De Las
Michel Guillon Jean-Rogeraugue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of FR2656220A1 publication Critical patent/FR2656220A1/fr
Application granted granted Critical
Publication of FR2656220B1 publication Critical patent/FR2656220B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR9015904A 1989-12-22 1990-12-19 Agents bloquants de l'effet ou de la formation du facteur edrf pour le traitement des chocs. Expired - Fee Related FR2656220B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898929076A GB8929076D0 (en) 1989-12-22 1989-12-22 Treatment of shock by blocking agents of edrf effect or formation

Publications (2)

Publication Number Publication Date
FR2656220A1 FR2656220A1 (fr) 1991-06-28
FR2656220B1 true FR2656220B1 (fr) 1995-01-13

Family

ID=10668428

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9015904A Expired - Fee Related FR2656220B1 (fr) 1989-12-22 1990-12-19 Agents bloquants de l'effet ou de la formation du facteur edrf pour le traitement des chocs.

Country Status (21)

Country Link
US (1) US5081148A (fr)
JP (1) JP2706578B2 (fr)
KR (1) KR950005866B1 (fr)
AT (1) AT403122B (fr)
AU (1) AU629777B2 (fr)
BE (1) BE1005531A5 (fr)
CA (1) CA2032904C (fr)
CH (1) CH681692A5 (fr)
DE (1) DE4041283C2 (fr)
DK (1) DK176168B1 (fr)
FR (1) FR2656220B1 (fr)
GB (2) GB8929076D0 (fr)
HK (1) HK134693A (fr)
IE (1) IE64403B1 (fr)
IT (1) IT1246511B (fr)
LU (1) LU87867A1 (fr)
MY (1) MY105328A (fr)
NL (1) NL194717C (fr)
OA (1) OA09337A (fr)
SE (1) SE504922C2 (fr)
ZA (1) ZA9010004B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE468881B (sv) * 1991-01-09 1993-04-05 Kabi Pharmacia Ab Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9200114D0 (en) * 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase
US5385940A (en) * 1992-11-05 1995-01-31 The General Hospital Corporation Treatment of stroke with nitric-oxide releasing compounds
US5585402A (en) * 1992-12-23 1996-12-17 Glaxo Wellcome Inc. Nitric oxide synthase inhibitors
US5436270A (en) * 1993-04-07 1995-07-25 National Science Council Method for protecting against endotoxin-induced shock
GB9312204D0 (en) * 1993-06-14 1993-07-28 Zeneca Ltd Therapeutic composition
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
US6090846A (en) * 1994-06-01 2000-07-18 Glaxo Wellcome Inc. Substituted urea and isothiourea derivatives as no synthase inhibitors
US6225305B1 (en) 1993-10-04 2001-05-01 Glaxo Wellcome Inc. Substituted urea and isothiorea derivatives as no synthase inhibitors
US6297276B1 (en) 1993-10-04 2001-10-02 Glaxosmithkline Substituted urea and isothiourea derivatives as no synthase inhibitors
JPH09504028A (ja) * 1993-10-21 1997-04-22 ジー．ディー．サール アンド カンパニー 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体
US5821267A (en) * 1993-10-21 1998-10-13 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
GB9404400D0 (en) * 1994-03-07 1994-04-20 Wood Pauline J Potentiation of bioreductive agents
ATE195933T1 (de) * 1994-03-10 2000-09-15 Searle & Co L-n6-(1-iminoethyl)lysin - derivate und ihre verwendung als no-synthase - inhibitoren
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
FR2727111B1 (fr) * 1994-11-21 1997-01-17 Hoechst Lab Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments
EP0799051B1 (fr) * 1994-12-12 2005-07-27 Omeros Corporation Solution d'irrigation et utilisation de celle-ci pour inhiber perioperativement la douleur, l'inflammation et les spasmes au niveau d'une plaie
KR100517210B1 (ko) * 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
FR2730930B1 (fr) 1995-02-27 1997-04-04 Oreal Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives
KR100442561B1 (ko) * 1995-04-20 2004-10-14 지.디. 썰 엘엘씨 ５산화２질소신타아제의억제제로유용한환상아미디노제
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
BR9509985A (pt) * 1995-12-12 1998-11-03 Omeros Med Sys Inc Solução para irrigação e método para inibição de dor inflamação e esparmo
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US6620848B2 (en) 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
JP2002517502A (ja) 1998-06-10 2002-06-18 ジー・ディー・サール・アンド・カンパニー 複素二環状及び三環状一酸化窒素シンターゼ阻害剤
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
CA2552195C (fr) 2003-12-30 2012-01-24 Vasopharm Biotech Gmbh 4-amino-7,8-dihydropteridines, compositions pharmaceutiques les contenant, et leur utilisation pour traiter des maladies causees par une augmentation du niveau d'oxyde nitrique

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB931921A (en) * 1960-12-22 1963-07-24 Lab Roques Therapeutic compositions intended for the treatment of any hepatic malfunctionings
GB1195612A (en) * 1967-04-13 1970-06-17 Sumitomo Chemical Co An Injection
FR2115060A1 (en) * 1970-11-26 1972-07-07 Metabio Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin
CA1029660A (fr) * 1973-06-01 1978-04-18 Kyowa Hakko Kogyo Co. Prevention des lesions gastriques
FR2320759A1 (fr) * 1975-08-11 1977-03-11 Union Pharma Scient Appl Solution d'acide acetylsalicylique extemporanee injectable
IT1127321B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizione farmaceutiche aventi specifiche proprieta' terapeutiche nei confronti dell'edema polmonare acuto,di alcuni stati di shock e dell'iperfibrinolisi
IT1127322B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
JPS5781409A (en) * 1980-11-10 1982-05-21 Toko Yakuhin Kogyo Kk External plaster
JPS57197211A (en) * 1981-05-28 1982-12-03 Sumitomo Chem Co Ltd Useful eye drop composition
JPS57200361A (en) * 1981-06-03 1982-12-08 Sumitomo Chem Co Ltd "indomethacin(r)" pharmaceutical with low irritant action
JPH0236570B2 (ja) * 1985-05-30 1990-08-17 Toko Yakuhin Kogyo Kk Shoenchintsunankozai
JPS6239524A (ja) * 1985-08-13 1987-02-20 Toko Yakuhin Kogyo Kk 消炎鎮痛軟膏剤
IT1201511B (it) * 1985-12-23 1989-02-02 Italfarmaco Spa Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono
AU1489688A (en) * 1987-02-20 1988-09-14 Shriners Hospitals For Crippled Children Omega-3 fatty acids in traumatic injury treatment

Also Published As

Publication number Publication date
AU629777B2 (en) 1992-10-08
IT9022413A0 (it) 1990-12-18
HK134693A (en) 1993-12-17
NL194717C (nl) 2003-01-07
CH681692A5 (fr) 1993-05-14
AU6837690A (en) 1991-06-27
JP2706578B2 (ja) 1998-01-28
KR910011253A (ko) 1991-08-07
LU87867A1 (fr) 1991-05-07
JPH04364124A (ja) 1992-12-16
AT403122B (de) 1997-11-25
DK304190D0 (da) 1990-12-21
DK304190A (da) 1991-06-23
GB2240041B (en) 1993-09-01
NL194717B (nl) 2002-09-02
CA2032904A1 (fr) 1991-06-23
FR2656220A1 (fr) 1991-06-28
CA2032904C (fr) 1996-01-02
US5081148A (en) 1992-01-14
ATA260690A (de) 1997-04-15
GB2240041A (en) 1991-07-24
BE1005531A5 (fr) 1993-09-28
IE64403B1 (en) 1995-08-09
SE504922C2 (sv) 1997-05-26
ZA9010004B (en) 1991-10-30
MY105328A (en) 1994-09-30
KR950005866B1 (ko) 1995-06-02
DE4041283A1 (de) 1991-06-27
NL9002720A (nl) 1991-07-16
IT1246511B (it) 1994-11-19
IT9022413A1 (it) 1991-06-23
SE9003974L (sv) 1991-06-23
GB8929076D0 (en) 1990-02-28
DE4041283C2 (de) 2000-07-13
OA09337A (fr) 1992-09-15
SE9003974D0 (sv) 1990-12-12
DK176168B1 (da) 2006-11-13
IE904592A1 (en) 1991-07-03
GB9028013D0 (en) 1991-02-13

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20100831