FR2639637A1 - Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments - Google Patents

Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments Download PDF

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Publication number
FR2639637A1
FR2639637A1 FR8915766A FR8915766A FR2639637A1 FR 2639637 A1 FR2639637 A1 FR 2639637A1 FR 8915766 A FR8915766 A FR 8915766A FR 8915766 A FR8915766 A FR 8915766A FR 2639637 A1 FR2639637 A1 FR 2639637A1
Authority
FR
France
Prior art keywords
formula
compound
compounds
och
metabolite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8915766A
Other languages
English (en)
French (fr)
Other versions
FR2639637B1 (enrdf_load_stackoverflow
Inventor
Maximilian Grassberger
Gerhard Schulz
Theodor Fehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2639637A1 publication Critical patent/FR2639637A1/fr
Application granted granted Critical
Publication of FR2639637B1 publication Critical patent/FR2639637B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR8915766A 1988-11-29 1989-11-27 Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments Granted FR2639637A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3840185 1988-11-29
DE3917779 1989-05-31

Publications (2)

Publication Number Publication Date
FR2639637A1 true FR2639637A1 (fr) 1990-06-01
FR2639637B1 FR2639637B1 (enrdf_load_stackoverflow) 1994-08-19

Family

ID=25874647

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8915766A Granted FR2639637A1 (fr) 1988-11-29 1989-11-27 Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments

Country Status (6)

Country Link
JP (1) JPH02275884A (enrdf_load_stackoverflow)
BE (1) BE1003436A3 (enrdf_load_stackoverflow)
CH (1) CH678855A5 (enrdf_load_stackoverflow)
FR (1) FR2639637A1 (enrdf_load_stackoverflow)
GB (1) GB2225576B (enrdf_load_stackoverflow)
IT (1) IT1237429B (enrdf_load_stackoverflow)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2245891A (en) * 1990-07-09 1992-01-15 Fujisawa Pharmaceutical Co Tricyclo compounds
GB2246350A (en) * 1990-07-23 1992-01-29 Fujisawa Pharmaceutical Co Tricyclo compounds
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
CA2051872A1 (en) * 1990-09-24 1992-03-25 Kevin M. Byrne Directed biosynthesis process for prolyl-immunomycin
EP0647625A1 (en) * 1992-06-23 1995-04-12 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Novel antibiotics with immunosuppressive activity, delaminomycins, and production thereof
CA2138129A1 (en) * 1992-06-24 1994-01-06 Masato Satoh Novel benzodiazepine derivative
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
AU2003213024A1 (en) 2002-02-13 2003-09-04 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method for extracting a macrolide from biomatter

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184162A2 (en) * 1984-12-03 1986-06-11 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
EP0323042A1 (en) * 1987-12-09 1989-07-05 FISONS plc Process to macrocyclic compounds
EP0349061A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant agent
EP0349049A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant compound
EP0353678A2 (en) * 1988-08-01 1990-02-07 Fujisawa Pharmaceutical Co., Ltd. FR-901154 and FR-901155 substances, a process for their production
EP0358508A2 (en) * 1988-09-08 1990-03-14 Merck & Co. Inc. Novel immunosuppressant compound

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184162A2 (en) * 1984-12-03 1986-06-11 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
EP0323042A1 (en) * 1987-12-09 1989-07-05 FISONS plc Process to macrocyclic compounds
EP0349061A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant agent
EP0349049A2 (en) * 1988-06-29 1990-01-03 Merck & Co. Inc. Immunosuppressant compound
EP0353678A2 (en) * 1988-08-01 1990-02-07 Fujisawa Pharmaceutical Co., Ltd. FR-901154 and FR-901155 substances, a process for their production
EP0358508A2 (en) * 1988-09-08 1990-03-14 Merck & Co. Inc. Novel immunosuppressant compound

Also Published As

Publication number Publication date
FR2639637B1 (enrdf_load_stackoverflow) 1994-08-19
GB2225576B (en) 1992-07-01
IT8948610A0 (it) 1989-11-29
GB2225576A (en) 1990-06-06
BE1003436A3 (fr) 1992-03-24
CH678855A5 (enrdf_load_stackoverflow) 1991-11-15
GB8926787D0 (en) 1990-01-17
IT8948610A1 (it) 1991-05-29
IT1237429B (it) 1993-06-04
JPH02275884A (ja) 1990-11-09

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