BE1003436A3 - Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments. - Google Patents
Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments. Download PDFInfo
- Publication number
- BE1003436A3 BE1003436A3 BE8901266A BE8901266A BE1003436A3 BE 1003436 A3 BE1003436 A3 BE 1003436A3 BE 8901266 A BE8901266 A BE 8901266A BE 8901266 A BE8901266 A BE 8901266A BE 1003436 A3 BE1003436 A3 BE 1003436A3
- Authority
- BE
- Belgium
- Prior art keywords
- metabolites
- medicines
- preparation
- cyclic derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention a pour objet les composés de formule I dans laquelle R1, R2 et X ont des significations variées, et quatre métabolites de structure non connue, désignés métabolites A, B, C et D. Ces composés peuvent être obtenus par synthèse et par fermentation de souches de Streptomyces par exemple la souche Spreptomyces tsukubaensis Nr. 9993. L'invention concerne également l'utilisation de ces composés comme médicamants.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3840185 | 1988-11-29 | ||
DE3917779 | 1989-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1003436A3 true BE1003436A3 (fr) | 1992-03-24 |
Family
ID=25874647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8901266A BE1003436A3 (fr) | 1988-11-29 | 1989-11-27 | Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments. |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPH02275884A (fr) |
BE (1) | BE1003436A3 (fr) |
CH (1) | CH678855A5 (fr) |
FR (1) | FR2639637A1 (fr) |
GB (1) | GB2225576B (fr) |
IT (1) | IT1237429B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2245891A (en) * | 1990-07-09 | 1992-01-15 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
GB2246350A (en) * | 1990-07-23 | 1992-01-29 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
US5023262A (en) * | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
CA2051872A1 (fr) * | 1990-09-24 | 1992-03-25 | Kevin M. Byrne | Procede de biosynthese dirigee de la prolyl-immunomycine |
AU675651B2 (en) * | 1992-06-23 | 1997-02-13 | Zaidan Hojin Biseibutsu Kagaku Kenkyukai | Novel antibiotics with immunosuppressive activity, delaminomycins, and production thereof |
AU670597B2 (en) * | 1992-06-24 | 1996-07-25 | Ferring B.V. | Novel benzodiazepine derivative |
PL374059A1 (en) | 2002-02-13 | 2005-09-19 | Teva Gyogyszergyar Reszvenytarsasag | Method for extracting a macrolide from biomatter |
US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0184162A2 (fr) * | 1984-12-03 | 1986-06-11 | Fujisawa Pharmaceutical Co., Ltd. | Composés tricycliques, procédé pour leur préparation et composition pharmaceutique les contenant |
EP0323042A1 (fr) * | 1987-12-09 | 1989-07-05 | FISONS plc | Procédé pour macrolides |
EP0349061A2 (fr) * | 1988-06-29 | 1990-01-03 | Merck & Co. Inc. | Agent immuno-suppresseur |
EP0349049A2 (fr) * | 1988-06-29 | 1990-01-03 | Merck & Co. Inc. | Composés immunosuppressants |
EP0353678A2 (fr) * | 1988-08-01 | 1990-02-07 | Fujisawa Pharmaceutical Co., Ltd. | Dérivés FR-901154 et FR-901155, procédé pour leur production |
EP0358508A2 (fr) * | 1988-09-08 | 1990-03-14 | Merck & Co. Inc. | Composé immunosuppreseur |
-
1989
- 1989-11-27 CH CH4236/89A patent/CH678855A5/de not_active IP Right Cessation
- 1989-11-27 FR FR8915766A patent/FR2639637A1/fr active Granted
- 1989-11-27 GB GB8926787A patent/GB2225576B/en not_active Expired - Lifetime
- 1989-11-27 BE BE8901266A patent/BE1003436A3/fr not_active IP Right Cessation
- 1989-11-28 JP JP1308836A patent/JPH02275884A/ja active Pending
- 1989-11-29 IT IT04861089A patent/IT1237429B/it active IP Right Grant
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0184162A2 (fr) * | 1984-12-03 | 1986-06-11 | Fujisawa Pharmaceutical Co., Ltd. | Composés tricycliques, procédé pour leur préparation et composition pharmaceutique les contenant |
EP0323042A1 (fr) * | 1987-12-09 | 1989-07-05 | FISONS plc | Procédé pour macrolides |
EP0349061A2 (fr) * | 1988-06-29 | 1990-01-03 | Merck & Co. Inc. | Agent immuno-suppresseur |
EP0349049A2 (fr) * | 1988-06-29 | 1990-01-03 | Merck & Co. Inc. | Composés immunosuppressants |
EP0353678A2 (fr) * | 1988-08-01 | 1990-02-07 | Fujisawa Pharmaceutical Co., Ltd. | Dérivés FR-901154 et FR-901155, procédé pour leur production |
EP0358508A2 (fr) * | 1988-09-08 | 1990-03-14 | Merck & Co. Inc. | Composé immunosuppreseur |
Also Published As
Publication number | Publication date |
---|---|
CH678855A5 (fr) | 1991-11-15 |
IT8948610A0 (it) | 1989-11-29 |
GB2225576B (en) | 1992-07-01 |
IT1237429B (it) | 1993-06-04 |
GB2225576A (en) | 1990-06-06 |
GB8926787D0 (en) | 1990-01-17 |
FR2639637A1 (fr) | 1990-06-01 |
JPH02275884A (ja) | 1990-11-09 |
FR2639637B1 (fr) | 1994-08-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: S.A. SANDOZ Effective date: 19951130 |