FR2624022B1 - Appareil de perfusion contenant des hepatocytes et procedes pour sa preparation et son utilisation - Google Patents
Appareil de perfusion contenant des hepatocytes et procedes pour sa preparation et son utilisationInfo
- Publication number
- FR2624022B1 FR2624022B1 FR8814280A FR8814280A FR2624022B1 FR 2624022 B1 FR2624022 B1 FR 2624022B1 FR 8814280 A FR8814280 A FR 8814280A FR 8814280 A FR8814280 A FR 8814280A FR 2624022 B1 FR2624022 B1 FR 2624022B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- methods
- infusion apparatus
- apparatus containing
- containing hepatocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
- A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
- A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Emergency Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- External Artificial Organs (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/116,525 US5043260A (en) | 1987-11-02 | 1987-11-02 | Perfusion device with hepatocytes |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2624022A1 FR2624022A1 (fr) | 1989-06-09 |
FR2624022B1 true FR2624022B1 (fr) | 1997-10-31 |
Family
ID=22367712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8814280A Expired - Fee Related FR2624022B1 (fr) | 1987-11-02 | 1988-11-02 | Appareil de perfusion contenant des hepatocytes et procedes pour sa preparation et son utilisation |
Country Status (6)
Country | Link |
---|---|
US (1) | US5043260A (fr) |
JP (1) | JPH01198559A (fr) |
CA (1) | CA1305935C (fr) |
DE (1) | DE3837226C2 (fr) |
FR (1) | FR2624022B1 (fr) |
GB (1) | GB2211857B (fr) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5605835A (en) * | 1988-05-23 | 1997-02-25 | Regents Of The University Of Minnesota | Bioreactor device with application as a bioartificial liver |
AU9031591A (en) * | 1990-10-29 | 1992-05-26 | Regents Of The University Of Minnesota | A bioartificial liver |
US5270192A (en) * | 1991-02-07 | 1993-12-14 | Monsanto Company | Biological artificial liver |
ATE140726T1 (de) * | 1992-02-07 | 1996-08-15 | Monsanto Co | Biologische künstliche leber |
DE4230194C2 (de) * | 1992-09-09 | 1995-07-27 | Joerg Dr Med Gerlach | Reaktor zur Züchtung und zur Nutzung von Stoffwechselleistungen und/oder zum Erhalt von Mikroorganismen |
CN1127995A (zh) * | 1992-09-11 | 1996-07-31 | 艾格塞诺吉耐克斯股份有限公司 | 人造肝装置及其用于血液和血浆体外净化的方法 |
US5368555A (en) * | 1992-12-29 | 1994-11-29 | Hepatix, Inc. | Organ support system |
US5866420A (en) * | 1993-10-08 | 1999-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Artificial liver device |
US5792603A (en) * | 1995-04-27 | 1998-08-11 | Advanced Tissue Sciences, Inc. | Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts |
US5846828A (en) * | 1995-06-07 | 1998-12-08 | Advanced Tissue Sciences | Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments |
US6121042A (en) * | 1995-04-27 | 2000-09-19 | Advanced Tissue Sciences, Inc. | Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs |
US5843766A (en) * | 1995-06-07 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Apparatus for the growth and packaging of three dimensional tissue cultures |
WO1996039992A1 (fr) * | 1995-06-07 | 1996-12-19 | Advanced Tissue Sciences, Inc. | Appareil et procede pour steriliser, ensemencer, cultiver, stocker, expedier et tester des tissus cartilagineux de remplacement produits par assemblage |
US6680166B1 (en) * | 1995-06-07 | 2004-01-20 | Claudy Jean Paul Mullon | Dual fiber bioreactor |
US6017760A (en) * | 1995-10-10 | 2000-01-25 | Rhode Island Hospital | Isolation and culture of porcine hepatocytes |
US5763267A (en) * | 1996-04-16 | 1998-06-09 | Advanced Tissue Sciences | Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures |
US5827729A (en) | 1996-04-23 | 1998-10-27 | Advanced Tissue Sciences | Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue |
US6409699B1 (en) * | 1996-10-22 | 2002-06-25 | Renal Solutions, Inc. | Continuous flow-through peritoneal dialysis (CFPD) method with control of intraperitoneal pressure |
DE59804998D1 (de) | 1997-02-04 | 2002-09-05 | Mat Adsorption Technologies Gm | Membranmodul enthaltend mindestens zwei gruppen von hohlfasermembranen und verfahren zu seiner herstellung |
US6723284B1 (en) * | 1997-04-11 | 2004-04-20 | University Of Pittsburgh | Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing |
US5993406A (en) | 1997-05-14 | 1999-11-30 | Cedars-Sinai Medical Center | Artificial gut |
US5955353A (en) * | 1997-05-22 | 1999-09-21 | Excorp Medical, Inc. | Hollow fiber bioreactor with an extrafilament flow plug |
JP3553858B2 (ja) * | 1999-08-25 | 2004-08-11 | 東洋紡績株式会社 | 血管網類似構造体を有する細胞培養用モジュール |
US6737270B1 (en) | 1999-12-07 | 2004-05-18 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Long-term three dimensional tissue culture system |
US20030096411A1 (en) * | 1999-12-07 | 2003-05-22 | George Michalopoulos | Novel long-term three-dimensional tissue culture system |
US6541243B1 (en) | 2000-06-05 | 2003-04-01 | Axon Instruments, Inc. | Perfusion chamber for electrophysiological testing of oocytes |
EP1234553A1 (fr) * | 2001-02-14 | 2002-08-28 | Boris-Wolfgang Hochleitner | Dispositif bioartificiel |
US20070037277A1 (en) * | 2001-04-25 | 2007-02-15 | Michael Shuler | Pharmacokinetic-based culture system with biological barriers |
US20070048727A1 (en) * | 2001-04-25 | 2007-03-01 | Michael Shuler | Biliary barrier |
JP4260627B2 (ja) * | 2001-04-25 | 2009-04-30 | コーネル リサーチ ファンデイション インコーポレイテッド | 薬物動態学に基づく細胞培養システムのためのデバイスおよび方法 |
IL164079A0 (en) * | 2002-03-15 | 2005-12-18 | Us Dept Veterans Affairs | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
BR0314471A (pt) * | 2002-10-10 | 2005-08-02 | Us Dept Veterans Affairs | Detecção, localização e estadiamento de tumores usando linfócitos ativados classificados dirigidos a um epitopo especìfico do tumor |
US20040151729A1 (en) * | 2002-10-28 | 2004-08-05 | George Michalopoulos | Novel long-term three-dimensional culture system |
US20050266393A1 (en) * | 2003-10-01 | 2005-12-01 | Baxter Gregory T | Circulating flow device for assays of cell cultures, cellular components and cell products |
JP2008539787A (ja) * | 2005-05-18 | 2008-11-20 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 生物学的な障壁を有する薬物動態学ベース培養システム |
JPWO2007023711A1 (ja) * | 2005-08-22 | 2009-02-26 | 学校法人早稲田大学 | 微生物の培養装置及び培養器並びに培養方法 |
US20070172943A1 (en) * | 2005-11-07 | 2007-07-26 | Robert Freedman | Devices and methods for culturing, preserving, transporting, storing, reconstituting and assaying cellular materials |
ES2672201T3 (es) | 2008-07-16 | 2018-06-13 | Children's Medical Center Corporation | Dispositivo de imitación de órganos con microcanales y métodos de uso |
DE102009037015A1 (de) * | 2009-08-07 | 2011-02-17 | Michael Hajek | Vorrichtung und Verfahren zur Eliminierung von bioschädlichen Stoffen aus Körperflüssigkeiten |
EP2444478A1 (fr) | 2010-10-22 | 2012-04-25 | Gerlach, Jörg, Dr. med. | Système d'échange de masses de fluide d'un corps tubulaire et dispositif d'échange de masses |
KR101957923B1 (ko) | 2011-02-28 | 2019-03-14 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 세포 배양 시스템 |
US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
WO2015013332A1 (fr) | 2013-07-22 | 2015-01-29 | President And Fellows Of Harvard College | Ensemble cartouche microfluidique |
CN106459898A (zh) | 2013-12-20 | 2017-02-22 | 哈佛大学校长及研究员协会 | 低剪切微流控装置及其使用方法和制造方法 |
JP6815985B2 (ja) | 2014-07-14 | 2021-01-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 流体システムおよびマイクロ流体システムの改善された性能のためのシステムおよび方法 |
US10202569B2 (en) | 2015-07-24 | 2019-02-12 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
AU2016406837B2 (en) * | 2016-05-19 | 2020-07-23 | Koji Saito | Culture device, culture method and cultured organ produced by culture method |
CN106267397B (zh) * | 2016-07-29 | 2019-02-05 | 武汉仝干医疗科技股份有限公司 | 毛绒线式生物反应器人工肝系统 |
US20200231938A1 (en) | 2016-09-13 | 2020-07-23 | President And Fellows Of Harvard College | Methods relating to intestinal organ-on-a-chip |
CN112672678A (zh) * | 2018-06-27 | 2021-04-16 | 日内瓦基金会 | 用于移动治疗单器官和多器官衰竭的可穿戴模块化体外生命支持设备 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3734851A (en) * | 1969-12-29 | 1973-05-22 | K Matsumura | Method and device for purifying blood |
US4675002A (en) * | 1985-12-02 | 1987-06-23 | Viles Joseph M | Liver assist device employing transformed cell lines |
US4853324A (en) * | 1985-12-02 | 1989-08-01 | Viles Joseph M | Liver assist device employing transformed cell lines |
US4869826A (en) * | 1987-09-01 | 1989-09-26 | Process Biotechnology, Inc. | Cellular adsorbents for removal of viral contaminants from blood and complex protein solutions |
-
1987
- 1987-11-02 US US07/116,525 patent/US5043260A/en not_active Expired - Lifetime
-
1988
- 1988-11-01 CA CA000581799A patent/CA1305935C/fr not_active Expired - Fee Related
- 1988-11-02 FR FR8814280A patent/FR2624022B1/fr not_active Expired - Fee Related
- 1988-11-02 GB GB8825583A patent/GB2211857B/en not_active Expired - Fee Related
- 1988-11-02 DE DE3837226A patent/DE3837226C2/de not_active Expired - Fee Related
- 1988-11-02 JP JP63278532A patent/JPH01198559A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA1305935C (fr) | 1992-08-04 |
GB8825583D0 (en) | 1988-12-07 |
GB2211857B (en) | 1991-10-30 |
DE3837226A1 (de) | 1989-05-24 |
DE3837226C2 (de) | 1994-09-22 |
FR2624022A1 (fr) | 1989-06-09 |
US5043260A (en) | 1991-08-27 |
JPH01198559A (ja) | 1989-08-10 |
GB2211857A (en) | 1989-07-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |