FR2530238A1 - - Google Patents

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Publication number
FR2530238A1
FR2530238A1 FR8311764A FR8311764A FR2530238A1 FR 2530238 A1 FR2530238 A1 FR 2530238A1 FR 8311764 A FR8311764 A FR 8311764A FR 8311764 A FR8311764 A FR 8311764A FR 2530238 A1 FR2530238 A1 FR 2530238A1
Authority
FR
France
Prior art keywords
radical
formula
hydrogen atom
lower alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8311764A
Other languages
English (en)
French (fr)
Other versions
FR2530238B1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2530238A1 publication Critical patent/FR2530238A1/fr
Application granted granted Critical
Publication of FR2530238B1 publication Critical patent/FR2530238B1/fr
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR838311764A 1982-07-19 1983-07-13 Expired FR2530238B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (2)

Publication Number Publication Date
FR2530238A1 true FR2530238A1 (es) 1984-01-20
FR2530238B1 FR2530238B1 (es) 1989-06-30

Family

ID=23580391

Family Applications (3)

Application Number Title Priority Date Filing Date
FR838311764A Expired FR2530238B1 (es) 1982-07-19 1983-07-13
FR8400114A Pending FR2540866A1 (fr) 1982-07-19 1984-01-05 Acides aminocetone carboxyliques utilisables comme intermediaires pour la preparation de peptides substitues
FR8400115A Expired FR2540867B1 (fr) 1982-07-19 1984-01-05 Halo-aminocetones utilisables comme intermediaires pour la preparation de peptides substitues

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR8400114A Pending FR2540866A1 (fr) 1982-07-19 1984-01-05 Acides aminocetone carboxyliques utilisables comme intermediaires pour la preparation de peptides substitues
FR8400115A Expired FR2540867B1 (fr) 1982-07-19 1984-01-05 Halo-aminocetones utilisables comme intermediaires pour la preparation de peptides substitues

Country Status (21)

Country Link
JP (3) JPS5951246A (es)
KR (1) KR840005709A (es)
AU (1) AU1643283A (es)
BE (1) BE897327A (es)
CA (1) CA1244006A (es)
CH (1) CH659475A5 (es)
DE (1) DE3325850A1 (es)
DK (1) DK330683A (es)
ES (4) ES524200A0 (es)
FI (1) FI832620A (es)
FR (3) FR2530238B1 (es)
GB (1) GB2123834B (es)
GR (1) GR79602B (es)
HU (1) HU187090B (es)
IE (1) IE55818B1 (es)
IL (1) IL69136A0 (es)
IT (1) IT1163800B (es)
NL (1) NL8302562A (es)
PT (1) PT77045B (es)
SE (1) SE8304031L (es)
ZA (1) ZA834980B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
DE3588094T2 (de) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive Derivate
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3414099A1 (en) 2017-01-10 2018-12-19 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012401A1 (en) * 1978-12-11 1980-06-25 Merck & Co. Inc. Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them
EP0038758A1 (fr) * 1980-04-17 1981-10-28 Societe Civile Bioprojet Dérivés d'acides aminés et leur application thérapeutique
EP0045161A1 (en) * 1980-07-24 1982-02-03 Imperial Chemical Industries Plc Amides of 4-oxo-5-amidohexanoic acid derivatives
EP0050800A1 (en) * 1980-10-23 1982-05-05 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
EP0054862A1 (en) * 1980-12-18 1982-06-30 Schering Corporation Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
GR75019B (es) * 1980-09-17 1984-07-12 Univ Miami
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012401A1 (en) * 1978-12-11 1980-06-25 Merck & Co. Inc. Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them
EP0038758A1 (fr) * 1980-04-17 1981-10-28 Societe Civile Bioprojet Dérivés d'acides aminés et leur application thérapeutique
EP0045161A1 (en) * 1980-07-24 1982-02-03 Imperial Chemical Industries Plc Amides of 4-oxo-5-amidohexanoic acid derivatives
EP0050800A1 (en) * 1980-10-23 1982-05-05 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
EP0054862A1 (en) * 1980-12-18 1982-06-30 Schering Corporation Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 12, 1980, pages 1392-1398, American Chemical Society; R.G. ALMQUIST: "Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme" *

Also Published As

Publication number Publication date
HUT34040A (en) 1985-01-28
GB2123834A (en) 1984-02-08
AU1643283A (en) 1984-01-26
BE897327A (fr) 1984-01-19
FR2540866A1 (fr) 1984-08-17
FR2530238B1 (es) 1989-06-30
JPH0526775B2 (es) 1993-04-19
ZA834980B (en) 1984-03-28
SE8304031D0 (sv) 1983-07-18
ES8707549A1 (es) 1986-04-01
GB2123834B (en) 1986-10-22
GB8318492D0 (en) 1983-08-10
JPH0532601A (ja) 1993-02-09
IT8322114A0 (it) 1983-07-18
ES539084A0 (es) 1986-04-01
ES8504675A1 (es) 1985-04-16
PT77045A (en) 1983-08-01
GR79602B (es) 1984-10-31
FR2540867A1 (fr) 1984-08-17
FI832620A (fi) 1984-01-20
DK330683A (da) 1984-01-20
FI832620A0 (fi) 1983-07-19
HU187090B (en) 1985-11-28
PT77045B (en) 1986-02-12
DK330683D0 (da) 1983-07-18
IT1163800B (it) 1987-04-08
ES8707550A1 (es) 1986-04-01
DE3325850A1 (de) 1984-01-19
IE831655L (en) 1984-01-19
ES539082A0 (es) 1986-05-16
SE8304031L (sv) 1984-03-30
IL69136A0 (en) 1983-10-31
IE55818B1 (en) 1991-01-30
ES539083A0 (es) 1986-04-01
ES524200A0 (es) 1985-04-16
ES8707548A1 (es) 1986-05-16
JPH0645582B2 (ja) 1994-06-15
CA1244006A (en) 1988-11-01
JPH0653713B2 (ja) 1994-07-20
CH659475A5 (fr) 1987-01-30
JPS5951246A (ja) 1984-03-24
KR840005709A (ko) 1984-11-16
NL8302562A (nl) 1984-02-16
FR2540867B1 (fr) 1987-07-31
JPH0517420A (ja) 1993-01-26

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Legal Events

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ST Notification of lapse