FR2485740A1 - Procede permettant d'ameliorer la sensibilite d'un lysat d'amibocytes de limule (lal) vis-a-vis de l'endotoxine, reactif lal correspondant, et utilisation de ce reactif pour determiner la presence d'endotoxines - Google Patents

Procede permettant d'ameliorer la sensibilite d'un lysat d'amibocytes de limule (lal) vis-a-vis de l'endotoxine, reactif lal correspondant, et utilisation de ce reactif pour determiner la presence d'endotoxines Download PDF

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Publication number
FR2485740A1
FR2485740A1 FR8112598A FR8112598A FR2485740A1 FR 2485740 A1 FR2485740 A1 FR 2485740A1 FR 8112598 A FR8112598 A FR 8112598A FR 8112598 A FR8112598 A FR 8112598A FR 2485740 A1 FR2485740 A1 FR 2485740A1
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France
Prior art keywords
radical
lysate
sensitivity
carbon atoms
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8112598A
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English (en)
French (fr)
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FR2485740B1 (en, 2012
Inventor
Roxane N Dikeman
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Mallinckrodt Inc
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Mallinckrodt Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26859656&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2485740(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of FR2485740A1 publication Critical patent/FR2485740A1/fr
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Publication of FR2485740B1 publication Critical patent/FR2485740B1/fr
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
FR8112598A 1980-06-27 1981-06-26 Procede permettant d'ameliorer la sensibilite d'un lysat d'amibocytes de limule (lal) vis-a-vis de l'endotoxine, reactif lal correspondant, et utilisation de ce reactif pour determiner la presence d'endotoxines Granted FR2485740A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16345680A 1980-06-27 1980-06-27
US06/254,233 US4322217A (en) 1980-06-27 1981-04-14 Process for preparing Limulus lysate

Publications (2)

Publication Number Publication Date
FR2485740A1 true FR2485740A1 (fr) 1981-12-31
FR2485740B1 FR2485740B1 (en, 2012) 1985-05-24

Family

ID=26859656

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8112598A Granted FR2485740A1 (fr) 1980-06-27 1981-06-26 Procede permettant d'ameliorer la sensibilite d'un lysat d'amibocytes de limule (lal) vis-a-vis de l'endotoxine, reactif lal correspondant, et utilisation de ce reactif pour determiner la presence d'endotoxines

Country Status (9)

Country Link
US (1) US4322217A (en, 2012)
AU (1) AU545395B2 (en, 2012)
CH (1) CH647871A5 (en, 2012)
DE (1) DE3125181A1 (en, 2012)
FR (1) FR2485740A1 (en, 2012)
GB (1) GB2080524B (en, 2012)
IT (1) IT1211070B (en, 2012)
NL (1) NL8103113A (en, 2012)
SE (1) SE447029B (en, 2012)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827557D0 (en) * 1988-11-25 1988-12-29 Radiometer Corporate Dev Ltd Process for handling horseshoe crab amoebocyte lysate
US5002015A (en) * 1988-12-09 1991-03-26 Aerotrace Hydraulics, Inc. Submerged treadmill system for exercising animals
DE69029785T2 (de) * 1989-10-30 1997-05-28 Biowhittaker Inc Kinetische Bestimmungsmethode für Endotoxin unter Verwendung von Limulus-Amoebocyten-Lysat und chromogenem Substrat
JP2957251B2 (ja) * 1990-09-28 1999-10-04 生化学工業株式会社 エンドトキシンの測定法
DE69211973T2 (de) * 1991-12-25 1996-12-19 Maruha Corp Reagenzien und Verfahren zur Bestimmung von Beta-Glucanen
JP2737514B2 (ja) * 1992-01-24 1998-04-08 和光純薬工業株式会社 エンドトキシン測定用試料の前処理方法
CA2112776C (en) * 1993-01-21 2002-11-12 Masakazu Tsuchiya Process for inhibiting activity of endotoxin
JP3242733B2 (ja) * 1993-02-26 2001-12-25 生化学工業株式会社 エンドトキシン特異的測定剤
JP3429036B2 (ja) * 1993-09-30 2003-07-22 生化学工業株式会社 エンドトキシンの特異的測定剤
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
US5637474A (en) * 1994-10-31 1997-06-10 Wako Pure Chemical Industries, Ltd. Process for measuring amount of endotoxin or (1→3)-β-D-glucan by kinetic turbidimetric method
US6270982B1 (en) 1997-10-09 2001-08-07 Charles River Laboratories Methods and compositions for the detection of bacterial endotoxins
ATE437886T1 (de) * 2001-06-28 2009-08-15 Lonza Walkersville Inc Verfahren und reagentien zum nachweis von endotoxin
US20040138577A1 (en) * 2002-12-20 2004-07-15 Kline Jeffrey A. Disposable hand-held device for collection of exhaled breath condensate
US7828741B2 (en) * 2002-12-20 2010-11-09 The Charlotte-Mecklenburg Hospital Authority Utilizing lipopolysaccharide in exhaled breath condensate to diagnose gram negative pneumonia
WO2004073497A2 (en) * 2003-02-14 2004-09-02 The Charlotte-Mecklenburg Hospital Authority Device and method for collection of exhaled alveolar breath condensate
EP1606414B1 (en) 2003-03-17 2009-12-23 Charles River Laboratories, Inc. Methods and compositions for the detection of microbial contaminants
EP1627040A2 (en) * 2003-04-18 2006-02-22 Associates Of Cape Cod, Inc. Kit for detecting endotoxin in aqueous solutions
US20050048655A1 (en) * 2003-04-18 2005-03-03 Novitsky Thomas J. Kit for detecting endotoxin
US7968280B2 (en) * 2004-12-02 2011-06-28 Charles River Laboratories, Inc. Methods for the detection and/or quantification of gram positive bacterial contaminants
JP5096166B2 (ja) 2005-01-13 2012-12-12 チャールズ リバー ラボラトリーズ, インコーポレイテッド 生体サンプル中の微生物を分類する方法
US20090286692A1 (en) * 2008-04-15 2009-11-19 Wainwright Norman R Cartridge and Method for Sample Analysis
EP2147981A1 (en) 2008-07-25 2010-01-27 Biotype AG Kit and method for evaluating detection properties in amplification reactions
JP5437660B2 (ja) 2009-02-19 2014-03-12 興和株式会社 コアギュロゲン原料及びその製造方法、それを用いた生物由来の生理活性物質の測定方法及び測定装置
MY155541A (en) * 2010-10-29 2015-10-30 Universiti Malaysia Terengganu Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab
CU24073B1 (es) 2011-12-27 2015-01-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem COMPOSICIÓN A PARTIR DE EXTRACTO DE HEMOCITOS DE LANGOSTA PARA LA DETECCIÓN DE LIPOPOLISACÁRIDOS, PEPTIDOGLICANOS Y 1,3-ß-D-GLUCANOS
EP3494226B1 (en) 2016-08-03 2021-09-22 Lonza Walkersville, Inc. Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen
US12158471B2 (en) 2022-02-11 2024-12-03 Charles River Laboratories, Inc. Recombinant amebocyte lysate and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1464280A (fr) * 1964-12-28 1966-12-30 Monsanto Co Compositions d'adjuvants et détergents contenant ces compositions
US3539521A (en) * 1965-05-03 1970-11-10 Procter & Gamble Detergent composition
FR2279105A1 (fr) * 1974-07-17 1976-02-13 Baxter Laboratories Inc Lysat de limulus ayant une capacite accrue a precipiter en presence de faibles concentrations d'endotoxine, et solutions de reconstitution appropriees
FR2438269A1 (fr) * 1978-10-06 1980-04-30 Baxter Travenol Lab Procede optique de mesure de concentration d'endotoxines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280179A (en) * 1961-03-16 1966-10-18 Textilana Corp Processes for producing acyclic surfactant sulfobetaines
US3915805A (en) * 1970-05-25 1975-10-28 Univ Johns Hopkins Quantitative detection of endotoxin in biological fluids
US3954663A (en) * 1972-12-18 1976-05-04 Teikoku Horinine Mfg. Co. Ltd. Process for the preparation of Limulina lysate
US3944391A (en) 1974-12-27 1976-03-16 Preventive Systems, Inc. In vitro process for detecting endotoxin in a biological fluid
US4107077A (en) * 1975-07-14 1978-08-15 Associates Of Cape Cod, Inc. Limulus lysate of improved sensitivity and preparing the same
US4038029A (en) * 1976-01-20 1977-07-26 Worthington Biochemical Corporation Limulus lysate turbidity test for pyrogens
GB1522127A (en) 1976-07-23 1978-08-23 Mallinckrodt Inc Limulus amebocyte lysate reagent compositions
GB2019563B (en) 1978-04-20 1982-07-28 Harvard College Assay of gram-negative bacteria
US4273557A (en) * 1980-03-31 1981-06-16 Mallinckrodt, Inc. Limulus lysate procedure for determining endotoxins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1464280A (fr) * 1964-12-28 1966-12-30 Monsanto Co Compositions d'adjuvants et détergents contenant ces compositions
US3539521A (en) * 1965-05-03 1970-11-10 Procter & Gamble Detergent composition
FR2279105A1 (fr) * 1974-07-17 1976-02-13 Baxter Laboratories Inc Lysat de limulus ayant une capacite accrue a precipiter en presence de faibles concentrations d'endotoxine, et solutions de reconstitution appropriees
FR2438269A1 (fr) * 1978-10-06 1980-04-30 Baxter Travenol Lab Procede optique de mesure de concentration d'endotoxines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, volume 84, no. 3, 19 janvier 1976, réf. 13096v, page 97, COLUMBUS, OHIO (US); & Yakugaku Zasshi 1975, 95(8), 959-65, M. KOBAYASHI et al.: "Gelation reaction of Limulus lysate (Pre-gel) IV. Effect of alkaline earth metals and chelating agents on the gelation reaction of Limulus lysate". *

Also Published As

Publication number Publication date
DE3125181C2 (en, 2012) 1991-09-05
NL8103113A (nl) 1982-01-18
SE447029B (sv) 1986-10-20
SE8104016L (sv) 1981-12-28
GB2080524B (en) 1984-04-18
AU545395B2 (en) 1985-07-11
DE3125181A1 (de) 1982-03-04
IT1211070B (it) 1989-09-29
CH647871A5 (fr) 1985-02-15
NL192139B (en, 2012) 1996-10-01
US4322217A (en) 1982-03-30
FR2485740B1 (en, 2012) 1985-05-24
IT8122595A0 (it) 1981-06-26
GB2080524A (en) 1982-02-03
AU7232181A (en) 1982-01-07
NL192139C (en, 2012) 1997-02-04

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