FR2483928A1 - Derives de la n-trifluoracetyladriamycine, leur preparation et leurs utilisations therapeutiques - Google Patents

Derives de la n-trifluoracetyladriamycine, leur preparation et leurs utilisations therapeutiques Download PDF

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Publication number
FR2483928A1
FR2483928A1 FR8111336A FR8111336A FR2483928A1 FR 2483928 A1 FR2483928 A1 FR 2483928A1 FR 8111336 A FR8111336 A FR 8111336A FR 8111336 A FR8111336 A FR 8111336A FR 2483928 A1 FR2483928 A1 FR 2483928A1
Authority
FR
France
Prior art keywords
compounds
preparation
hemiadipate
hemiglutarate
trifluoracetyladriamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8111336A
Other languages
English (en)
French (fr)
Other versions
FR2483928B1 (cg-RX-API-DMAC10.html
Inventor
Israel Mervyn
Potti Gopalakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Sidney Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidney Farber Cancer Institute Inc filed Critical Sidney Farber Cancer Institute Inc
Publication of FR2483928A1 publication Critical patent/FR2483928A1/fr
Application granted granted Critical
Publication of FR2483928B1 publication Critical patent/FR2483928B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR8111336A 1980-06-09 1981-06-09 Derives de la n-trifluoracetyladriamycine, leur preparation et leurs utilisations therapeutiques Granted FR2483928A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/157,861 US4299822A (en) 1980-06-09 1980-06-09 N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same

Publications (2)

Publication Number Publication Date
FR2483928A1 true FR2483928A1 (fr) 1981-12-11
FR2483928B1 FR2483928B1 (cg-RX-API-DMAC10.html) 1984-01-06

Family

ID=22565590

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8111336A Granted FR2483928A1 (fr) 1980-06-09 1981-06-09 Derives de la n-trifluoracetyladriamycine, leur preparation et leurs utilisations therapeutiques

Country Status (8)

Country Link
US (1) US4299822A (cg-RX-API-DMAC10.html)
JP (1) JPS5767596A (cg-RX-API-DMAC10.html)
CA (1) CA1150245A (cg-RX-API-DMAC10.html)
CH (1) CH645387A5 (cg-RX-API-DMAC10.html)
DE (1) DE3122689C2 (cg-RX-API-DMAC10.html)
FR (1) FR2483928A1 (cg-RX-API-DMAC10.html)
GB (1) GB2077265B (cg-RX-API-DMAC10.html)
NL (1) NL184420C (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
RU2758670C1 (ru) * 2020-12-30 2021-11-01 федеральное государственное бюджетное образовательное учреждение высшего образования «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) Новое химическое соединение 5-фторурацила и доксорубицина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2135221A1 (en) * 1971-05-04 1972-12-15 Farmaceutici Italia Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acid
GB1368680A (en) * 1972-12-09 1974-10-02 Farmaceutici Italia Adriamycin derivatives
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives

Also Published As

Publication number Publication date
FR2483928B1 (cg-RX-API-DMAC10.html) 1984-01-06
CH645387A5 (de) 1984-09-28
GB2077265B (en) 1984-01-11
DE3122689A1 (de) 1982-05-06
US4299822A (en) 1981-11-10
GB2077265A (en) 1981-12-16
NL8102730A (nl) 1982-01-04
DE3122689C2 (de) 1985-07-04
JPS632440B2 (cg-RX-API-DMAC10.html) 1988-01-19
JPS5767596A (en) 1982-04-24
CA1150245A (en) 1983-07-19
NL184420C (nl) 1989-07-17

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Date Code Title Description
ST Notification of lapse