DE3122689C2 - N-Trifluoracetyl-adriamycin-14-0-hemiglutarat und -hemiadipat und diese Verbindungen enthaltende pharmazeutische Zubereitungen - Google Patents

N-Trifluoracetyl-adriamycin-14-0-hemiglutarat und -hemiadipat und diese Verbindungen enthaltende pharmazeutische Zubereitungen

Info

Publication number
DE3122689C2
DE3122689C2 DE3122689A DE3122689A DE3122689C2 DE 3122689 C2 DE3122689 C2 DE 3122689C2 DE 3122689 A DE3122689 A DE 3122689A DE 3122689 A DE3122689 A DE 3122689A DE 3122689 C2 DE3122689 C2 DE 3122689C2
Authority
DE
Germany
Prior art keywords
adriamycin
trifluoroacetyl
hemiglutarate
compounds
hemiadipate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3122689A
Other languages
German (de)
English (en)
Other versions
DE3122689A1 (de
Inventor
Mervyn Needham Mass. Israel
Gopalakrishnan Lexington Ky. Potti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Sidney Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidney Farber Cancer Institute Inc filed Critical Sidney Farber Cancer Institute Inc
Publication of DE3122689A1 publication Critical patent/DE3122689A1/de
Application granted granted Critical
Publication of DE3122689C2 publication Critical patent/DE3122689C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE3122689A 1980-06-09 1981-06-06 N-Trifluoracetyl-adriamycin-14-0-hemiglutarat und -hemiadipat und diese Verbindungen enthaltende pharmazeutische Zubereitungen Expired DE3122689C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/157,861 US4299822A (en) 1980-06-09 1980-06-09 N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same

Publications (2)

Publication Number Publication Date
DE3122689A1 DE3122689A1 (de) 1982-05-06
DE3122689C2 true DE3122689C2 (de) 1985-07-04

Family

ID=22565590

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3122689A Expired DE3122689C2 (de) 1980-06-09 1981-06-06 N-Trifluoracetyl-adriamycin-14-0-hemiglutarat und -hemiadipat und diese Verbindungen enthaltende pharmazeutische Zubereitungen

Country Status (8)

Country Link
US (1) US4299822A (cg-RX-API-DMAC10.html)
JP (1) JPS5767596A (cg-RX-API-DMAC10.html)
CA (1) CA1150245A (cg-RX-API-DMAC10.html)
CH (1) CH645387A5 (cg-RX-API-DMAC10.html)
DE (1) DE3122689C2 (cg-RX-API-DMAC10.html)
FR (1) FR2483928A1 (cg-RX-API-DMAC10.html)
GB (1) GB2077265B (cg-RX-API-DMAC10.html)
NL (1) NL184420C (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
RU2758670C1 (ru) * 2020-12-30 2021-11-01 федеральное государственное бюджетное образовательное учреждение высшего образования «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО "ПИМУ" Минздрава России) Новое химическое соединение 5-фторурацила и доксорубицина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2135221A1 (en) * 1971-05-04 1972-12-15 Farmaceutici Italia Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acid
GB1368680A (en) * 1972-12-09 1974-10-02 Farmaceutici Italia Adriamycin derivatives
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
FR2483928B1 (cg-RX-API-DMAC10.html) 1984-01-06
FR2483928A1 (fr) 1981-12-11
CH645387A5 (de) 1984-09-28
GB2077265B (en) 1984-01-11
DE3122689A1 (de) 1982-05-06
US4299822A (en) 1981-11-10
GB2077265A (en) 1981-12-16
NL8102730A (nl) 1982-01-04
JPS632440B2 (cg-RX-API-DMAC10.html) 1988-01-19
JPS5767596A (en) 1982-04-24
CA1150245A (en) 1983-07-19
NL184420C (nl) 1989-07-17

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee