FR2483407A1 - Nouvelles alcoxy-acyl-carnitines, leur procede de preparation et compositions pharmaceutiques les contenant - Google Patents

Nouvelles alcoxy-acyl-carnitines, leur procede de preparation et compositions pharmaceutiques les contenant Download PDF

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Publication number
FR2483407A1
FR2483407A1 FR8110641A FR8110641A FR2483407A1 FR 2483407 A1 FR2483407 A1 FR 2483407A1 FR 8110641 A FR8110641 A FR 8110641A FR 8110641 A FR8110641 A FR 8110641A FR 2483407 A1 FR2483407 A1 FR 2483407A1
Authority
FR
France
Prior art keywords
carnitine
acyl
alkoxy
treatment
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8110641A
Other languages
English (en)
French (fr)
Other versions
FR2483407B1 (cg-RX-API-DMAC7.html
Inventor
Claudio Cavazza
Paolo De Witt
Maria Ornella Tinti
Emma Quaresima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of FR2483407A1 publication Critical patent/FR2483407A1/fr
Application granted granted Critical
Publication of FR2483407B1 publication Critical patent/FR2483407B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR8110641A 1980-05-30 1981-05-27 Nouvelles alcoxy-acyl-carnitines, leur procede de preparation et compositions pharmaceutiques les contenant Granted FR2483407A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48854/80A IT1145371B (it) 1980-05-30 1980-05-30 Alcossi-acil carnitine procedimento per la loro preparazione e composizioni farmaceutiche che le contengono

Publications (2)

Publication Number Publication Date
FR2483407A1 true FR2483407A1 (fr) 1981-12-04
FR2483407B1 FR2483407B1 (cg-RX-API-DMAC7.html) 1985-05-17

Family

ID=11268803

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8110641A Granted FR2483407A1 (fr) 1980-05-30 1981-05-27 Nouvelles alcoxy-acyl-carnitines, leur procede de preparation et compositions pharmaceutiques les contenant

Country Status (17)

Country Link
US (1) US4590209A (cg-RX-API-DMAC7.html)
JP (1) JPS5724339A (cg-RX-API-DMAC7.html)
KR (1) KR850000628B1 (cg-RX-API-DMAC7.html)
AT (1) AT373231B (cg-RX-API-DMAC7.html)
AU (1) AU540842B2 (cg-RX-API-DMAC7.html)
BE (1) BE888984A (cg-RX-API-DMAC7.html)
CA (1) CA1151208A (cg-RX-API-DMAC7.html)
CH (1) CH649528A5 (cg-RX-API-DMAC7.html)
DE (1) DE3120913A1 (cg-RX-API-DMAC7.html)
ES (1) ES8203329A1 (cg-RX-API-DMAC7.html)
FR (1) FR2483407A1 (cg-RX-API-DMAC7.html)
GB (1) GB2077258B (cg-RX-API-DMAC7.html)
IE (1) IE51447B1 (cg-RX-API-DMAC7.html)
IL (1) IL62890A (cg-RX-API-DMAC7.html)
IT (1) IT1145371B (cg-RX-API-DMAC7.html)
NL (1) NL191367C (cg-RX-API-DMAC7.html)
SE (1) SE454509B (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.
IT1177874B (it) * 1984-07-04 1987-08-26 Sigma Tau Ind Farmaceuti Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono
IT1208753B (it) * 1986-07-02 1989-07-10 Sigma Tau Ind Farmaceuti L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
IT1240799B (it) * 1990-03-15 1993-12-17 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti 3-metiltiopropionil l-carnitina ad attivita' sul sistema cardiovascolare.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2925945A1 (de) * 1978-06-27 1980-01-10 Sigma Tau Ind Farmaceuti Acylderivate von carnitin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
GB2071091A (en) * 1980-03-06 1981-09-16 Sigma Tau Ind Farmaceuti Acyl-derivatives of carnitine and the therapeutic use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS531812B2 (cg-RX-API-DMAC7.html) * 1972-12-07 1978-01-23
US4032641A (en) * 1976-06-09 1977-06-28 Tanabe Seiyaku Co., Ltd. Nicotinoyl carnitine derivatives
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
IT1156741B (it) * 1978-05-15 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi
IT1156769B (it) * 1978-05-25 1987-02-04 Sigma Tau Ind Farmaceuti Applicazione terapeutica della carnitina e di altri acil derivati della carnitina
JPS5633054A (en) * 1979-08-29 1981-04-03 Matsushita Electric Ind Co Ltd Dehydrator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2925945A1 (de) * 1978-06-27 1980-01-10 Sigma Tau Ind Farmaceuti Acylderivate von carnitin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
GB2071091A (en) * 1980-03-06 1981-09-16 Sigma Tau Ind Farmaceuti Acyl-derivatives of carnitine and the therapeutic use thereof

Also Published As

Publication number Publication date
ES502593A0 (es) 1982-04-01
AT373231B (de) 1983-12-27
IE51447B1 (en) 1986-12-24
KR830006184A (ko) 1983-09-20
IE811097L (en) 1981-11-30
ES8203329A1 (es) 1982-04-01
SE8103368L (sv) 1981-12-01
IL62890A (en) 1986-04-29
NL191367B (nl) 1995-01-16
JPS5724339A (en) 1982-02-08
KR850000628B1 (ko) 1985-05-06
NL8102538A (nl) 1981-12-16
AU540842B2 (en) 1984-12-06
DE3120913A1 (de) 1982-04-01
CH649528A5 (it) 1985-05-31
DE3120913C2 (cg-RX-API-DMAC7.html) 1991-07-18
ATA222981A (de) 1983-05-15
BE888984A (fr) 1981-09-16
FR2483407B1 (cg-RX-API-DMAC7.html) 1985-05-17
GB2077258B (en) 1984-01-11
CA1151208A (en) 1983-08-02
NL191367C (nl) 1995-06-16
JPH0320384B2 (cg-RX-API-DMAC7.html) 1991-03-19
AU7088381A (en) 1981-12-03
GB2077258A (en) 1981-12-16
IT1145371B (it) 1986-11-05
IL62890A0 (en) 1981-07-31
US4590209A (en) 1986-05-20
IT8048854A0 (it) 1980-05-30
SE454509B (sv) 1988-05-09

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