FR2478101A1 - Derives de mitomycine et utilisation de tels derives pour le traitement des etats de maladie neoplasique chez les animaux - Google Patents

Derives de mitomycine et utilisation de tels derives pour le traitement des etats de maladie neoplasique chez les animaux Download PDF

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Publication number
FR2478101A1
FR2478101A1 FR8025775A FR8025775A FR2478101A1 FR 2478101 A1 FR2478101 A1 FR 2478101A1 FR 8025775 A FR8025775 A FR 8025775A FR 8025775 A FR8025775 A FR 8025775A FR 2478101 A1 FR2478101 A1 FR 2478101A1
Authority
FR
France
Prior art keywords
methoxy
hexahydro
hydroxymethyl
methyl
azirino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8025775A
Other languages
English (en)
French (fr)
Other versions
FR2478101B1 (enExample
Inventor
William A Remers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Patents Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of FR2478101A1 publication Critical patent/FR2478101A1/fr
Application granted granted Critical
Publication of FR2478101B1 publication Critical patent/FR2478101B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8025775A 1979-12-05 1980-12-04 Derives de mitomycine et utilisation de tels derives pour le traitement des etats de maladie neoplasique chez les animaux Granted FR2478101A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/100,331 US4268676A (en) 1979-12-05 1979-12-05 Mitomycin analogs

Publications (2)

Publication Number Publication Date
FR2478101A1 true FR2478101A1 (fr) 1981-09-18
FR2478101B1 FR2478101B1 (enExample) 1984-06-08

Family

ID=22279228

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8025775A Granted FR2478101A1 (fr) 1979-12-05 1980-12-04 Derives de mitomycine et utilisation de tels derives pour le traitement des etats de maladie neoplasique chez les animaux
FR8108250A Granted FR2477016A1 (fr) 1979-12-05 1981-04-24 Compositions pharmaceutiques a base de derives de mitomycine pour le traitement de maladie neoplastique chez les animaux

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8108250A Granted FR2477016A1 (fr) 1979-12-05 1981-04-24 Compositions pharmaceutiques a base de derives de mitomycine pour le traitement de maladie neoplastique chez les animaux

Country Status (3)

Country Link
US (1) US4268676A (enExample)
JP (1) JPS5692288A (enExample)
FR (2) FR2478101A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460599A (en) * 1979-12-05 1984-07-17 University Patents, Inc. Mitomycin analogs
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
US4617389A (en) * 1981-05-15 1986-10-14 University Patents, Inc. Mitomycin analogs
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
DE3376114D1 (en) * 1982-12-07 1988-05-05 Kyowa Hakko Kogyo Kk Mitomycin analogues
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4579737A (en) * 1983-05-09 1986-04-01 Bristol-Myers Company Bis-amidines
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
US4691023A (en) * 1984-02-24 1987-09-01 Bristol-Myers Company Amino disulfides
US4866180A (en) * 1984-02-24 1989-09-12 Bristol-Myers Company Amino disulfide thiol exchange products
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
US5098926A (en) * 1984-09-04 1992-03-24 University Patents, Inc. 6-substituted mitomycin analogs
JPH066591B2 (ja) * 1985-04-10 1994-01-26 協和醗酵工業株式会社 マイトマイシン誘導体及び抗腫瘍剤
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs
AU628846B2 (en) * 1988-08-23 1992-09-24 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129868C (enExample) * 1963-06-07
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
FR1449947A (fr) * 1964-08-25 1966-05-06 Kyowa Hakko Kogyo Kk Procédé de préparation de mitomycines a 7-substituées

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin

Also Published As

Publication number Publication date
US4268676A (en) 1981-05-19
FR2477016A1 (fr) 1981-09-04
FR2477016B1 (enExample) 1984-06-08
JPS5692288A (en) 1981-07-25
FR2478101B1 (enExample) 1984-06-08

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