FR2475047A1 - Procedes d'obtention de relaxine humaine a partir de membranes foetales et relaxine ainsi obtenue - Google Patents
Procedes d'obtention de relaxine humaine a partir de membranes foetales et relaxine ainsi obtenue Download PDFInfo
- Publication number
- FR2475047A1 FR2475047A1 FR8101698A FR8101698A FR2475047A1 FR 2475047 A1 FR2475047 A1 FR 2475047A1 FR 8101698 A FR8101698 A FR 8101698A FR 8101698 A FR8101698 A FR 8101698A FR 2475047 A1 FR2475047 A1 FR 2475047A1
- Authority
- FR
- France
- Prior art keywords
- relaxin
- source
- human
- chorion
- membranes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 15
- 210000002219 extraembryonic membrane Anatomy 0.000 title claims abstract description 8
- BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title claims abstract description 7
- 108090000103 Relaxin Proteins 0.000 title claims description 19
- 102000003743 Relaxin Human genes 0.000 title claims description 19
- 210000001136 chorion Anatomy 0.000 claims description 10
- 210000001519 tissue Anatomy 0.000 claims description 7
- 239000000287 crude extract Substances 0.000 claims description 5
- 210000001691 amnion Anatomy 0.000 claims description 3
- 238000011534 incubation Methods 0.000 claims description 3
- 210000004379 membrane Anatomy 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 2
- 210000003463 organelle Anatomy 0.000 claims description 2
- 238000007790 scraping Methods 0.000 claims description 2
- 231100000732 tissue residue Toxicity 0.000 claims description 2
- 210000003785 decidua Anatomy 0.000 claims 2
- 208000035484 Cellulite Diseases 0.000 claims 1
- 206010049752 Peau d'orange Diseases 0.000 claims 1
- 230000036232 cellulite Effects 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- 230000001376 precipitating effect Effects 0.000 claims 1
- 229940088597 hormone Drugs 0.000 abstract description 3
- 239000005556 hormone Substances 0.000 abstract description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 241000124008 Mammalia Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 210000004061 pubic symphysis Anatomy 0.000 description 3
- 238000012384 transportation and delivery Methods 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012507 Sephadex™ Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010036595 Premature delivery Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 238000002559 palpation Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
- Y10S530/851—Placenta; amniotic fluid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
- Y10S530/852—Sperm
- Y10S530/853—Ovary; eggs; embryos
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pregnancy & Childbirth (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Gynecology & Obstetrics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/117,444 US4267101A (en) | 1980-02-01 | 1980-02-01 | Process for obtaining human relaxin from fetal membranes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2475047A1 true FR2475047A1 (fr) | 1981-08-07 |
| FR2475047B1 FR2475047B1 (enExample) | 1983-07-29 |
Family
ID=22372986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8101698A Granted FR2475047A1 (fr) | 1980-02-01 | 1981-01-29 | Procedes d'obtention de relaxine humaine a partir de membranes foetales et relaxine ainsi obtenue |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4267101A (enExample) |
| JP (1) | JPS56127315A (enExample) |
| AR (2) | AR227907A1 (enExample) |
| AT (1) | AT372856B (enExample) |
| AU (1) | AU540310B2 (enExample) |
| BE (1) | BE887324A (enExample) |
| CA (1) | CA1143286A (enExample) |
| CH (1) | CH647530A5 (enExample) |
| DE (1) | DE3102487C2 (enExample) |
| DK (1) | DK44181A (enExample) |
| ES (1) | ES498941A0 (enExample) |
| FR (1) | FR2475047A1 (enExample) |
| GB (1) | GB2068383B (enExample) |
| IL (1) | IL61931A (enExample) |
| IT (1) | IT8147648A0 (enExample) |
| NL (1) | NL8100243A (enExample) |
| SE (1) | SE8100614L (enExample) |
| ZA (1) | ZA81374B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5320953A (en) * | 1982-08-12 | 1994-06-14 | Howard Florey Institute Of Experimental Physiology And Medicine | Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof |
| US5053488A (en) * | 1982-08-12 | 1991-10-01 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a gene sequence coding for human relaxin |
| ES524885A0 (es) * | 1982-08-12 | 1985-12-16 | Florey Howard Inst | Un procedimiento para producir un vector de transferencia de adn. |
| DE3236264A1 (de) * | 1982-09-30 | 1984-04-05 | Serono Pharmazeutische Präparate GmbH, 7800 Freiburg | Verfahren zur gewinnung von relaxin |
| IL70414A (en) * | 1982-12-13 | 1991-06-10 | Florey Howard Inst | Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors |
| US5023321A (en) * | 1982-12-13 | 1991-06-11 | Howard Florey Institute Of Experimental Physiology & Medicine | Molecular cloning and characterization of a further gene sequence coding for human relaxin |
| EP0260149A1 (en) * | 1986-09-12 | 1988-03-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Human prorelaxin for therapeutic use |
| JP2815649B2 (ja) * | 1988-02-26 | 1998-10-27 | ジェネンテク，インコーポレイテッド | ヒトレラキシン製剤 |
| US6348327B1 (en) | 1991-12-06 | 2002-02-19 | Genentech, Inc. | Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells |
| US5612051A (en) * | 1995-11-17 | 1997-03-18 | Yue; Samuel K. | Method of treating involuntary muscle dysfunction with relaxin hormone |
| US6251863B1 (en) | 1998-09-08 | 2001-06-26 | Samuel K. Yue | Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin |
| AU2005247332A1 (en) * | 2004-04-30 | 2005-12-08 | Corthera, Inc. | Methods and compositions for control of fetal growth via modulation of relaxin |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852432A (en) * | 1953-08-11 | 1958-09-16 | Warner Lambert Pharmaceutical | Process for purification of relaxin by ion exchange |
| US2930737A (en) * | 1955-11-15 | 1960-03-29 | Princeton Lab Inc | Process for the isolation of relaxin using glacial acetic acid |
| US2995494A (en) * | 1957-12-27 | 1961-08-08 | Ortho Pharma Corp | Process for purifying relaxin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852431A (en) * | 1954-05-17 | 1958-09-16 | Warner Lambert Pharmaceutical | Process for the extraction and purification of relaxin using trichloracetic acid |
-
1980
- 1980-02-01 US US06/117,444 patent/US4267101A/en not_active Expired - Lifetime
-
1981
- 1981-01-19 IL IL61931A patent/IL61931A/xx unknown
- 1981-01-20 ZA ZA81374A patent/ZA81374B/xx unknown
- 1981-01-20 NL NL8100243A patent/NL8100243A/nl not_active Application Discontinuation
- 1981-01-22 AT AT0026281A patent/AT372856B/de not_active IP Right Cessation
- 1981-01-26 DE DE3102487A patent/DE3102487C2/de not_active Expired
- 1981-01-26 CA CA000369263A patent/CA1143286A/en not_active Expired
- 1981-01-27 AU AU66614/81A patent/AU540310B2/en not_active Ceased
- 1981-01-28 IT IT8147648A patent/IT8147648A0/it unknown
- 1981-01-29 FR FR8101698A patent/FR2475047A1/fr active Granted
- 1981-01-29 SE SE8100614A patent/SE8100614L/xx not_active Application Discontinuation
- 1981-01-29 CH CH598/81A patent/CH647530A5/de not_active IP Right Cessation
- 1981-01-29 ES ES498941A patent/ES498941A0/es active Granted
- 1981-01-30 BE BE0/203662A patent/BE887324A/fr not_active IP Right Cessation
- 1981-01-30 DK DK44181A patent/DK44181A/da not_active Application Discontinuation
- 1981-01-30 AR AR284142A patent/AR227907A1/es active
- 1981-01-31 JP JP1222881A patent/JPS56127315A/ja active Granted
- 1981-02-02 GB GB8103103A patent/GB2068383B/en not_active Expired
-
1982
- 1982-02-09 AR AR288374A patent/AR227959A1/es active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852432A (en) * | 1953-08-11 | 1958-09-16 | Warner Lambert Pharmaceutical | Process for purification of relaxin by ion exchange |
| US2930737A (en) * | 1955-11-15 | 1960-03-29 | Princeton Lab Inc | Process for the isolation of relaxin using glacial acetic acid |
| US2995494A (en) * | 1957-12-27 | 1961-08-08 | Ortho Pharma Corp | Process for purifying relaxin |
Non-Patent Citations (1)
| Title |
|---|
| CA1978 * |
Also Published As
| Publication number | Publication date |
|---|---|
| NL8100243A (nl) | 1981-09-01 |
| DK44181A (da) | 1981-08-02 |
| US4267101A (en) | 1981-05-12 |
| GB2068383B (en) | 1983-05-11 |
| AT372856B (de) | 1983-11-25 |
| ES8203914A1 (es) | 1982-05-01 |
| AR227907A1 (es) | 1982-12-30 |
| ES498941A0 (es) | 1982-05-01 |
| IL61931A (en) | 1984-06-29 |
| ATA26281A (de) | 1983-04-15 |
| ZA81374B (en) | 1982-08-25 |
| IL61931A0 (en) | 1981-02-27 |
| AU540310B2 (en) | 1984-11-08 |
| AR227959A1 (es) | 1982-12-30 |
| GB2068383A (en) | 1981-08-12 |
| BE887324A (fr) | 1981-05-14 |
| JPS56127315A (en) | 1981-10-06 |
| DE3102487C2 (de) | 1983-06-16 |
| AU6661481A (en) | 1981-08-06 |
| FR2475047B1 (enExample) | 1983-07-29 |
| CA1143286A (en) | 1983-03-22 |
| CH647530A5 (de) | 1985-01-31 |
| DE3102487A1 (de) | 1982-01-07 |
| SE8100614L (sv) | 1981-08-02 |
| IT8147648A0 (it) | 1981-01-28 |
| JPS6157809B2 (enExample) | 1986-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |