FR2474508B1 - Procede pour obtenir des heparines de bas poids moleculaire ayant des proprietes pharmacologiques remarquables et produit ainsi obtenu - Google Patents

Procede pour obtenir des heparines de bas poids moleculaire ayant des proprietes pharmacologiques remarquables et produit ainsi obtenu

Info

Publication number
FR2474508B1
FR2474508B1 FR8101508A FR8101508A FR2474508B1 FR 2474508 B1 FR2474508 B1 FR 2474508B1 FR 8101508 A FR8101508 A FR 8101508A FR 8101508 A FR8101508 A FR 8101508A FR 2474508 B1 FR2474508 B1 FR 2474508B1
Authority
FR
France
Prior art keywords
product
molecular weight
low molecular
pharmacological properties
obtaining low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8101508A
Other languages
English (en)
Other versions
FR2474508A1 (fr
Inventor
Fernando Fussi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hepar Industries Inc
Original Assignee
Hepar Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hepar Industries Inc filed Critical Hepar Industries Inc
Publication of FR2474508A1 publication Critical patent/FR2474508A1/fr
Application granted granted Critical
Publication of FR2474508B1 publication Critical patent/FR2474508B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR8101508A 1980-01-28 1981-01-27 Procede pour obtenir des heparines de bas poids moleculaire ayant des proprietes pharmacologiques remarquables et produit ainsi obtenu Expired FR2474508B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11577880A 1980-01-28 1980-01-28
US06/155,674 US4281108A (en) 1980-01-28 1980-06-02 Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

Publications (2)

Publication Number Publication Date
FR2474508A1 FR2474508A1 (fr) 1981-07-31
FR2474508B1 true FR2474508B1 (fr) 1986-03-07

Family

ID=26813554

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8101508A Expired FR2474508B1 (fr) 1980-01-28 1981-01-27 Procede pour obtenir des heparines de bas poids moleculaire ayant des proprietes pharmacologiques remarquables et produit ainsi obtenu

Country Status (7)

Country Link
US (1) US4281108A (fr)
DE (1) DE3102621A1 (fr)
DK (1) DK168297B1 (fr)
FR (1) FR2474508B1 (fr)
GB (1) GB2068011B (fr)
IT (1) IT1141954B (fr)
NL (1) NL189043C (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2619136A (en) * 1950-07-10 1952-11-25 John D Nash Rectangular framework clamp
US2670773A (en) * 1950-12-18 1954-03-02 Edward L Avery Concrete form clamp and anchor holder
US3262595A (en) * 1963-09-27 1966-07-26 Johns Manville Lift truck clamp attachment
DE2827772C3 (de) * 1978-06-24 1981-02-26 Peter Strasser Rahmenspannvorrichtung für die Herstellung rechteckiger Rahmen, insbesondere Bilderrahmen
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
USRE35770E (en) * 1978-11-06 1998-04-14 Choay, S.A. Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
US4438261A (en) 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (fr) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides ayant un pouvoir anticoagulant selectif
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
CA1195322A (fr) * 1982-07-19 1985-10-15 Eduardo Amaya Procede de production d'heparines a faible poids moleculaire par depolarisation de l'heparine normale
DE3236578A1 (de) * 1982-10-02 1984-04-26 Bessey & Sohn Gmbh & Co, 7000 Stuttgart Rahmenspanngeraet
FR2538404B1 (fr) * 1982-12-28 1985-08-23 Anic Spa
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2543145B1 (fr) * 1983-03-24 1986-10-17 Sanofi Sa Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante
FR2553287B1 (fr) * 1983-10-18 1986-09-12 Choay Sa Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
US4745107A (en) * 1986-08-20 1988-05-17 Foley Kevin M Heparin derivatives with improved permeability
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
US4745105A (en) * 1986-08-20 1988-05-17 Griffin Charles C Low molecular weight heparin derivatives with improved permeability
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
CZ232593A3 (en) * 1991-05-02 1994-07-13 Yeda Res & Dev Pharmaceutical preparation for preventing and/or therapy of pathological states
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
CA2235223A1 (fr) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Lyases de polysaccharides designees rationnellement derivees de l'heparinase i
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
CA2341412A1 (fr) * 1998-08-27 2000-03-09 Massachusetts Institute Of Technology Heparinases a conception rationnelle derivees de l'heparinase i et ii
US6597996B1 (en) * 1999-04-23 2003-07-22 Massachusetts Institute Of Technology Method for indentifying or characterizing properties of polymeric units
AU4351201A (en) * 2000-03-08 2001-09-17 Massachusetts Inst Technology Heparinase iii and uses thereof
KR20000053816A (ko) * 2000-04-20 2000-09-05 조석형 저분자 다당류 및 그의 올리고당 제조방법
ES2324701T3 (es) * 2000-09-12 2009-08-13 Massachusetts Institute Of Technology Metodos y productos relacionados con heparina de peso molecular bajo.
WO2002032406A2 (fr) * 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Procedes et produits associes a l'administration pulmonaires de polysaccharides
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
US20040122354A1 (en) * 2002-09-05 2004-06-24 Semba Charles P. Infusion catheter having an integrated doppler transducer
EP3997238A1 (fr) 2019-07-09 2022-05-18 Optimvia, LLC Procédés de synthèse de polysaccharides anticoagulants
EP4182452A1 (fr) 2020-07-14 2023-05-24 Optimvia, LLC Procédés de synthèse de sulfate d'héparane non anticoagulant

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB867064A (en) * 1959-05-16 1961-05-03 Roussel Uclaf New derivatives of heparin and processes for their production
NL286444A (fr) * 1961-12-08
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche

Also Published As

Publication number Publication date
DK36881A (da) 1981-07-29
GB2068011B (en) 1983-07-27
US4281108A (en) 1981-07-28
DE3102621A1 (de) 1981-12-10
DK168297B1 (da) 1994-03-07
FR2474508A1 (fr) 1981-07-31
DE3102621C2 (fr) 1992-08-06
GB2068011A (en) 1981-08-05
IT1141954B (it) 1986-10-08
NL189043C (nl) 1992-12-16
NL8100354A (nl) 1981-08-17
NL189043B (nl) 1992-07-16
IT8119321A0 (it) 1981-01-26

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Legal Events

Date Code Title Description
ST Notification of lapse