FR2471784A1 - Medicaments antiarythmiques a action prolongee dont le principe actif est le a/2-/bis (1-methylethyl) amino/ethyl/-a-phenyl-2-pyridine acetamide ou ses sels, ainsi que le procede de preparation de ces nouveaux medicaments et compositions les renfermant - Google Patents
Medicaments antiarythmiques a action prolongee dont le principe actif est le a/2-/bis (1-methylethyl) amino/ethyl/-a-phenyl-2-pyridine acetamide ou ses sels, ainsi que le procede de preparation de ces nouveaux medicaments et compositions les renfermant Download PDFInfo
- Publication number
- FR2471784A1 FR2471784A1 FR7931443A FR7931443A FR2471784A1 FR 2471784 A1 FR2471784 A1 FR 2471784A1 FR 7931443 A FR7931443 A FR 7931443A FR 7931443 A FR7931443 A FR 7931443A FR 2471784 A1 FR2471784 A1 FR 2471784A1
- Authority
- FR
- France
- Prior art keywords
- ethyl
- bis
- phenyl
- amino
- methylethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 BIS (1-METHYLETHYL) AMINO Chemical class 0.000 title claims abstract description 10
- 239000003416 antiarrhythmic agent Substances 0.000 title claims abstract description 7
- 238000002360 preparation method Methods 0.000 title claims abstract description 5
- 239000003814 drug Substances 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 7
- 125000001495 ethyl group Chemical class [H]C([H])([H])C([H])([H])* 0.000 title claims description 3
- 239000000203 mixture Substances 0.000 title abstract description 7
- 239000004480 active ingredient Substances 0.000 title description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 9
- 239000000194 fatty acid Substances 0.000 claims abstract description 9
- 229930195729 fatty acid Natural products 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 12
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 7
- 150000002148 esters Chemical class 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 4
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 2
- PYAPITOPBTXXNJ-UHFFFAOYSA-N 2-phenyl-2-pyridin-2-ylacetamide Chemical compound C=1C=CC=NC=1C(C(=O)N)C1=CC=CC=C1 PYAPITOPBTXXNJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 239000002775 capsule Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- UVTNFZQICZKOEM-UHFFFAOYSA-N disopyramide Chemical compound C=1C=CC=NC=1C(C(N)=O)(CCN(C(C)C)C(C)C)C1=CC=CC=C1 UVTNFZQICZKOEM-UHFFFAOYSA-N 0.000 description 6
- 229960001066 disopyramide Drugs 0.000 description 6
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 229940126601 medicinal product Drugs 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 description 2
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- GQWNECFJGBQMBO-UHFFFAOYSA-N Molindone hydrochloride Chemical compound Cl.O=C1C=2C(CC)=C(C)NC=2CCC1CN1CCOCC1 GQWNECFJGBQMBO-UHFFFAOYSA-N 0.000 description 1
- 208000000418 Premature Cardiac Complexes Diseases 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical class [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 description 1
- ZJXZSIYSNXKHEA-UHFFFAOYSA-N ethyl dihydrogen phosphate Chemical compound CCOP(O)(O)=O ZJXZSIYSNXKHEA-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000008510 paroxysmal tachycardia Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7931443A FR2471784A1 (fr) | 1979-12-21 | 1979-12-21 | Medicaments antiarythmiques a action prolongee dont le principe actif est le a/2-/bis (1-methylethyl) amino/ethyl/-a-phenyl-2-pyridine acetamide ou ses sels, ainsi que le procede de preparation de ces nouveaux medicaments et compositions les renfermant |
| SE8007640A SE8007640L (sv) | 1979-12-21 | 1980-10-30 | Antiarytmiska lekemedel med forlengd verkan vars aktiva huvudbestandsdel er 1'alfa-(bis(1-metyl-etyl)-amino)etyl)-alfa-fenyl-2-pyridinacetamid eller ett salt derav, framstellning derav och kompositioner innehallande ... |
| ZA00807807A ZA807807B (en) | 1979-12-21 | 1980-12-12 | Antiarrhytmic medicaments with prolonged action of which the active principle is a-(2-(bis(1-methylethyl)amino)ethyl)-a-phenyl-2-pyridine-acetamide or one of its salts,their preparation and the compositions containing them |
| MA19224A MA19021A1 (fr) | 1979-12-21 | 1980-12-18 | Procede de preparation de compositions pharmaceutiques a base d'alpha-12-bis(i methyl ethyl)amino/alpha-phenyl 2-pyridine acetamide ou de l'un de ses sels |
| JP17817480A JPS56118016A (en) | 1979-12-21 | 1980-12-18 | Long term functional antiarrhythmic drug whose active component is alphaa*22*bis*11 methylethyl*amino*ethyl**alphaaphenyll22 pyridineacetamide or one of salts* its manufacture and composition containi |
| IT50423/80A IT1144024B (it) | 1979-12-21 | 1980-12-19 | Medicamenti antiaritmici con azione prolungata contenenti come principio attivo alfa-(2(bis-(1-metil-etil)-ammino)-etil)-alfa-fenil-2-piridin-acetammide o suoi sali e procedimento per la loro preparazione |
| AU65604/80A AU543380B2 (en) | 1979-12-21 | 1980-12-19 | Slow-release compositions of disopyramide |
| PT72256A PT72256B (fr) | 1979-12-21 | 1980-12-19 | Procede de preparation de compositions pharmaceutiques a base de alpha-/2-/bis-(1-methyl ethyl)-amino/ethyl/alpha-phenyl-2-pyridine acetamide ou d'un de ses sels |
| GB8040813A GB2068226B (en) | 1979-12-21 | 1980-12-19 | Antiarrhythmic sustained release disopyramide compositions |
| NL8006938A NL191171C (nl) | 1979-12-21 | 1980-12-19 | Tablet met aritmie-bestrijdende werking. |
| CA000367273A CA1151067A (fr) | 1979-12-21 | 1980-12-19 | COMPOSITIONS PHARMACEUTIQUES ANTIARYTHMIQUES A ACTION PROLONGEE DONT LE PRINCIPE ACTIF EST 1'.alpha.-/2-/BIS (1-METHYL ETHYL) AMINO (ETHYL) .alpha.-PHENYL 2-PYRIDINE ACETAMIDEOU L'UN DE SES SELS |
| BE0/203250A BE886774A (fr) | 1979-12-21 | 1980-12-19 | Medicaments antiarythmiques a action prolongee leur preparation et les compositions les renferment |
| DE19803048154 DE3048154A1 (de) | 1979-12-21 | 1980-12-19 | Antiarrhythmische mittel mit langzeitwirkung, ihre herstellung und pharmazeutische zusammensetzungen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7931443A FR2471784A1 (fr) | 1979-12-21 | 1979-12-21 | Medicaments antiarythmiques a action prolongee dont le principe actif est le a/2-/bis (1-methylethyl) amino/ethyl/-a-phenyl-2-pyridine acetamide ou ses sels, ainsi que le procede de preparation de ces nouveaux medicaments et compositions les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2471784A1 true FR2471784A1 (fr) | 1981-06-26 |
| FR2471784B1 FR2471784B1 (enrdf_load_stackoverflow) | 1982-12-17 |
Family
ID=9233075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7931443A Granted FR2471784A1 (fr) | 1979-12-21 | 1979-12-21 | Medicaments antiarythmiques a action prolongee dont le principe actif est le a/2-/bis (1-methylethyl) amino/ethyl/-a-phenyl-2-pyridine acetamide ou ses sels, ainsi que le procede de preparation de ces nouveaux medicaments et compositions les renfermant |
Country Status (13)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982004392A1 (fr) * | 1981-06-18 | 1982-12-23 | Uclaf Roussel | Procede de preparation de compositions pharmaceutiques a base d'(alpha)-/2-/bis (1-methylethyl) amino/ethyl(alpha)-phenyl 2-pyridine acetamide ou de l'un de ses sels |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789549A (en) * | 1987-03-09 | 1988-12-06 | Warner-Lambert Company | Sustained release dosage forms |
| JPH08143450A (ja) * | 1994-11-14 | 1996-06-04 | Taiyo Yakuhin Kogyo Kk | 徐放化製剤 |
| ME02135B (me) | 2006-03-16 | 2015-04-30 | Euro Celtique Sa | Farmaceutski sferoidi |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3062720A (en) * | 1959-05-20 | 1962-11-06 | Philips Roxane | Sustained release pharmaceutical tablet |
| FR2485M (fr) * | 1961-05-17 | 1964-04-27 | Searle & Co | Nouveaux régulateurs cardiaques. |
| BE708434A (enrdf_load_stackoverflow) * | 1966-12-22 | 1968-05-02 | ||
| DE1492123A1 (de) * | 1962-06-22 | 1969-07-17 | Smith Kline French Lab | Verfahren zur Herstellung von Arzneipraeparaten in Tablettenform |
-
1979
- 1979-12-21 FR FR7931443A patent/FR2471784A1/fr active Granted
-
1980
- 1980-10-30 SE SE8007640A patent/SE8007640L/ not_active Application Discontinuation
- 1980-12-12 ZA ZA00807807A patent/ZA807807B/xx unknown
- 1980-12-18 MA MA19224A patent/MA19021A1/fr unknown
- 1980-12-18 JP JP17817480A patent/JPS56118016A/ja active Granted
- 1980-12-19 AU AU65604/80A patent/AU543380B2/en not_active Ceased
- 1980-12-19 PT PT72256A patent/PT72256B/pt unknown
- 1980-12-19 NL NL8006938A patent/NL191171C/xx not_active IP Right Cessation
- 1980-12-19 GB GB8040813A patent/GB2068226B/en not_active Expired
- 1980-12-19 CA CA000367273A patent/CA1151067A/fr not_active Expired
- 1980-12-19 DE DE19803048154 patent/DE3048154A1/de active Granted
- 1980-12-19 BE BE0/203250A patent/BE886774A/fr not_active IP Right Cessation
- 1980-12-19 IT IT50423/80A patent/IT1144024B/it active Protection Beyond IP Right Term
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3062720A (en) * | 1959-05-20 | 1962-11-06 | Philips Roxane | Sustained release pharmaceutical tablet |
| FR2485M (fr) * | 1961-05-17 | 1964-04-27 | Searle & Co | Nouveaux régulateurs cardiaques. |
| DE1492123A1 (de) * | 1962-06-22 | 1969-07-17 | Smith Kline French Lab | Verfahren zur Herstellung von Arzneipraeparaten in Tablettenform |
| BE708434A (enrdf_load_stackoverflow) * | 1966-12-22 | 1968-05-02 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982004392A1 (fr) * | 1981-06-18 | 1982-12-23 | Uclaf Roussel | Procede de preparation de compositions pharmaceutiques a base d'(alpha)-/2-/bis (1-methylethyl) amino/ethyl(alpha)-phenyl 2-pyridine acetamide ou de l'un de ses sels |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1144024B (it) | 1986-10-29 |
| DE3048154C2 (enrdf_load_stackoverflow) | 1992-03-19 |
| AU543380B2 (en) | 1985-04-18 |
| GB2068226A (en) | 1981-08-12 |
| FR2471784B1 (enrdf_load_stackoverflow) | 1982-12-17 |
| AU6560480A (en) | 1981-06-25 |
| SE8007640L (sv) | 1981-06-22 |
| ZA807807B (en) | 1982-01-27 |
| NL191171C (nl) | 1995-03-01 |
| NL191171B (nl) | 1994-10-03 |
| JPS56118016A (en) | 1981-09-16 |
| PT72256A (fr) | 1981-01-01 |
| PT72256B (fr) | 1982-07-15 |
| BE886774A (fr) | 1981-06-19 |
| JPH0141606B2 (enrdf_load_stackoverflow) | 1989-09-06 |
| GB2068226B (en) | 1984-03-21 |
| IT8050423A0 (it) | 1980-12-19 |
| NL8006938A (nl) | 1981-07-16 |
| CA1151067A (fr) | 1983-08-02 |
| DE3048154A1 (de) | 1981-09-03 |
| MA19021A1 (fr) | 1981-07-01 |
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