FR2455609A1 - 24-24-difluoro-25-hydroxycholecalciferol - Google Patents

24-24-difluoro-25-hydroxycholecalciferol

Info

Publication number
FR2455609A1
FR2455609A1 FR8018944A FR8018944A FR2455609A1 FR 2455609 A1 FR2455609 A1 FR 2455609A1 FR 8018944 A FR8018944 A FR 8018944A FR 8018944 A FR8018944 A FR 8018944A FR 2455609 A1 FR2455609 A1 FR 2455609A1
Authority
FR
France
Prior art keywords
difluoro
bopi
formula
design
hydroxycholecalciferol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8018944A
Other languages
English (en)
Other versions
FR2455609B1 (fr
Inventor
Hector F De Luca
Nobuo Ikekawa
Yoko Tanaka
Yoshiro Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2455609A1 publication Critical patent/FR2455609A1/fr
Application granted granted Critical
Publication of FR2455609B1 publication Critical patent/FR2455609B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

24,24-DIFLUORO-25-HYDROXYCHLOLECALCIFEROL. DERIVE DE LA VITAMINE D AYANT LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE AC DESIGNE UN RADICAL ACETYLE ET Q UN RADICAL DIFLUORO-CHOLESTEROL SUBSTITUE AYANT LA FORMULE: (CF DESSIN DANS BOPI) CE COMPOSE, UTILE DANS LA PREVENTION DU RACHITISME, PERMET D'ENTRETENIR PLUS LONGTEMPS, LORS DE SON APPLICATION, DES CONCENTRATIONS TISSULAIRES ELEVEES.
FR8018944A 1979-03-05 1980-09-02 24-24-difluoro-25-hydroxycholecalciferol Granted FR2455609A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/017,168 US4196133A (en) 1979-03-05 1979-03-05 24,24-Difluoro-25-hydroxycholecalciferol

Publications (2)

Publication Number Publication Date
FR2455609A1 true FR2455609A1 (fr) 1980-11-28
FR2455609B1 FR2455609B1 (fr) 1983-07-01

Family

ID=21781101

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8004852A Expired FR2450814B1 (fr) 1979-03-05 1980-03-04 24,24-difluoro-25-hydroxycholecalciferol et composition pharmaceutique renfermant ce produit
FR8018944A Granted FR2455609A1 (fr) 1979-03-05 1980-09-02 24-24-difluoro-25-hydroxycholecalciferol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR8004852A Expired FR2450814B1 (fr) 1979-03-05 1980-03-04 24,24-difluoro-25-hydroxycholecalciferol et composition pharmaceutique renfermant ce produit

Country Status (16)

Country Link
US (1) US4196133A (fr)
JP (2) JPS6310946B2 (fr)
AU (1) AU532388B2 (fr)
BE (1) BE882036A (fr)
CA (1) CA1157049A (fr)
CH (2) CH654015A5 (fr)
DK (3) DK156635C (fr)
FR (2) FR2450814B1 (fr)
GB (1) GB2044770B (fr)
IE (1) IE49532B1 (fr)
IL (1) IL58525A (fr)
IT (1) IT1151077B (fr)
NL (1) NL7920160A (fr)
NZ (1) NZ191899A (fr)
SE (1) SE8007427L (fr)
WO (1) WO1980001915A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4254045A (en) * 1980-04-21 1981-03-03 Wisconsin Alumni Research Foundation 1α-Hydroxy-2β-fluorocholecalciferol
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
US4428946A (en) * 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
IT1175607B (it) * 1983-08-18 1987-07-15 Wisconsin Alumni Res Found 23,23-difluoro-25-idrossi-e 1 alfa, 25-diidrossi-vitamina d3
US4500460A (en) * 1983-08-18 1985-02-19 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
US4564474A (en) * 1983-08-18 1986-01-14 Wisconsin Alumni Research Foundation 23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same
JPS6253960A (ja) * 1985-05-30 1987-03-09 Taisho Pharmaceut Co Ltd ビタミンｄ↓３の誘導体
IL139241A0 (en) * 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2453151A1 (fr) * 1979-02-16 1980-10-31 Yamada Sachiko Derives de la vitamine d3, leur procede de preparation et leur application en therapeutique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
US4069321A (en) * 1975-10-14 1978-01-17 Merck & Co., Inc. Blocked cholecalciferol and dihydrotachysterol 3 derivatives
US4028349A (en) * 1976-03-08 1977-06-07 Hoffmann-La Roche Inc. Syntheses of 24R,25- and 24S,25-dihydroxycholesterol 24,25-ketals and alkanoyl derivatives thereof
JPS595432B2 (ja) * 1976-11-09 1984-02-04 凸版印刷株式会社 容器の製造方法
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2453151A1 (fr) * 1979-02-16 1980-10-31 Yamada Sachiko Derives de la vitamine d3, leur procede de preparation et leur application en therapeutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/79 *

Also Published As

Publication number Publication date
CA1157049A (fr) 1983-11-15
FR2455609B1 (fr) 1983-07-01
FR2450814B1 (fr) 1986-04-11
GB2044770B (en) 1983-05-11
IL58525A0 (en) 1980-01-31
IL58525A (en) 1983-02-23
DK425183A (da) 1983-09-19
WO1980001915A1 (fr) 1980-09-18
DK425183D0 (da) 1983-09-19
DK156635C (da) 1990-02-12
AU5580980A (en) 1980-09-11
DK156644B (da) 1989-09-18
DK446482A (da) 1982-10-08
DK156726C (da) 1990-03-05
DK156635B (da) 1989-09-18
DK156644C (da) 1990-02-12
JPS56500064A (fr) 1981-01-22
CH653018A5 (de) 1985-12-13
IT1151077B (it) 1986-12-17
US4196133A (en) 1980-04-01
GB2044770A (en) 1980-10-22
IE800420L (en) 1980-09-05
CH654015A5 (de) 1986-01-31
JPH0142944B2 (fr) 1989-09-18
AU532388B2 (en) 1983-09-29
DK467780A (da) 1980-11-04
NZ191899A (en) 1984-11-09
JPS63183559A (ja) 1988-07-28
DK156726B (da) 1989-09-25
FR2450814A1 (fr) 1980-10-03
NL7920160A (nl) 1980-12-31
SE8007427L (sv) 1980-10-22
IE49532B1 (en) 1985-10-16
JPS6310946B2 (fr) 1988-03-10
IT8020326A0 (it) 1980-03-03
BE882036A (fr) 1980-07-01

Similar Documents

Publication Publication Date Title
NO2011026I2 (no) Eribulin eller et farmasøytisk akseptabelt salt derav
ES2094350T3 (es) Cromano y tiocromanos con sustituyentes de feniletinilo en la posicion 7 que tienen actividad biologica de tipo retinoide.
ES2022610B3 (es) Compuestos para potenciar la permeabilidad de la piel que utilizan esteres de sacarosa.
FR2387938A1 (fr) Fluorures o-carbonyles a-carboxyles fluores et leur preparation
ES2051700T3 (es) Un proceso para la preparacion de un compuesto beta-lactama.
ES2134804T3 (es) Uso de un compuesto generador de oxido nitrico para prevenir daño neuronal.
ES2078676T3 (es) Amidas de la glicilserina y composiciones cosmeticas, farmaceuticas o alimenticias que las contienen.
FR2372822A1 (fr) Derives polyoxygenes du labdane, leurs procedes de preparation et leur application
FR2392016A1 (fr) Derives de mevalonolactone, leur procede de preparation et leur application therapeutique
FR2387941A1 (fr) Homologue de la somatostatine, ses intermediaires de preparation, et son utilisation comme medicament
KR970074765A (ko) 비타민 d₃ 동족체
FR2455609A1 (fr) 24-24-difluoro-25-hydroxycholecalciferol
FR2384805A1 (fr) Sels de polyesters lineaires
ATE78465T1 (de) Kathartica.
ES2128043T3 (es) Uso de bis(amidinobencimidazoles) en la preparacion de un medicamento para inhibir la integrasa retroviral.
FR2398732A1 (fr) Nouveau sel d'aluminium soufre, son procede de preparation et compositions cosmetiques et pharmaceutiques le contenant
FR2387988A1 (fr) Esters de cefuroxime, leur preparation et leur application therapeutique
PT81786A (en) Dopamine beta-hydroxylase inhibitors
FR2658510B1 (fr) Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi.
FR2387214A1 (fr) Derives du p-aminomethyl benzene-sulfonamide, leur procede de preparation et leur application therapeutique
AR007052A1 (es) Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende
ES528816A0 (es) Procedimiento de producir compuestos para el tratamiento de la hipertension
FR2361345A1 (fr) Homologues de somatostatine, sa preparation et son utilisation therapeutique
CA1268468C (fr) Analogues des prostaglandines avec groupement thiabicycloheptane substitue
FR2358408A1 (fr) Nouveaux derives de cephalosporines, leur procede de preparation et leur application therapeutique

Legal Events

Date Code Title Description
ST Notification of lapse