ES2128043T3 - Uso de bis(amidinobencimidazoles) en la preparacion de un medicamento para inhibir la integrasa retroviral. - Google Patents
Uso de bis(amidinobencimidazoles) en la preparacion de un medicamento para inhibir la integrasa retroviral.Info
- Publication number
- ES2128043T3 ES2128043T3 ES95908504T ES95908504T ES2128043T3 ES 2128043 T3 ES2128043 T3 ES 2128043T3 ES 95908504 T ES95908504 T ES 95908504T ES 95908504 T ES95908504 T ES 95908504T ES 2128043 T3 ES2128043 T3 ES 2128043T3
- Authority
- ES
- Spain
- Prior art keywords
- bis
- amidinobencimidazoles
- preparation
- retroviral integrase
- medicinal product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100034343 Integrase Human genes 0.000 abstract 2
- 108010061833 Integrases Proteins 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000001177 retroviral effect Effects 0.000 abstract 2
- QZKOOEFIMWKZPK-UHFFFAOYSA-N 2-[(6-carbamimidoyl-1h-benzimidazol-2-yl)methyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(CC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 QZKOOEFIMWKZPK-UHFFFAOYSA-N 0.000 abstract 1
- DFFCDIMSXJYMTB-UHFFFAOYSA-N 2-[2-(6-carbamimidoyl-1h-benzimidazol-2-yl)ethenyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(C=CC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 DFFCDIMSXJYMTB-UHFFFAOYSA-N 0.000 abstract 1
- KIYLEUCIWFUYOC-UHFFFAOYSA-N 2-[2-(6-carbamimidoyl-1h-benzimidazol-2-yl)ethyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(CCC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 KIYLEUCIWFUYOC-UHFFFAOYSA-N 0.000 abstract 1
- 206010038997 Retroviral infections Diseases 0.000 abstract 1
- -1 bis-benzimidazole compound Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thin Film Transistor (AREA)
- Saccharide Compounds (AREA)
- Recrystallisation Techniques (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
Abstract
SE PRESENTA UN METODO PARA INHIBIR LA INTEGRASA RETROVIRAL EN UN SUJETO EN NECESIDAD DEL TRATAMIENTO. EL METODO COMPRENDE LA ADMINISTRACION AL SUJETO DE UNA CANTIDAD INHIBIDORA DE LA INTEGRASA RETROVIRAL DE UN COMPUESTO DE BIS-BENCIMIDAZOLA, TAL COMO BIS[5-AMIDINO-2-5-BENZIMIDAZOLIL]METANO, 1,2-BIS[5-AMIDINO2-BENZIMIDAZOLIL]ETANO, 1,2-BIS[5-AMIDINO-2-BENZIMIDAZOLIL]ETANO O UNA SAL FARMACOLOGICAMENTE ACEPTABLE DE LOS MISMOS. TAMBIEN SE PRESENTA UN METODO PARA COMBATIR LAS INFECCIONES RETROVIRALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/185,079 US6815461B1 (en) | 1994-01-20 | 1994-01-20 | Method of inhibiting retroviral integrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2128043T3 true ES2128043T3 (es) | 1999-05-01 |
Family
ID=22679488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95908504T Expired - Lifetime ES2128043T3 (es) | 1994-01-20 | 1995-01-18 | Uso de bis(amidinobencimidazoles) en la preparacion de un medicamento para inhibir la integrasa retroviral. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6815461B1 (es) |
| EP (1) | EP0739202B1 (es) |
| JP (1) | JP3306830B2 (es) |
| AT (1) | ATE174508T1 (es) |
| AU (1) | AU675386B2 (es) |
| BR (1) | BR9506552A (es) |
| CA (1) | CA2179015C (es) |
| DE (1) | DE69506686T2 (es) |
| ES (1) | ES2128043T3 (es) |
| NZ (2) | NZ279619A (es) |
| WO (1) | WO1995019772A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562854B2 (en) | 1994-12-14 | 2003-05-13 | Axys Pharmaceuticals, Inc. | Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders |
| US5693515A (en) * | 1995-04-28 | 1997-12-02 | Arris Pharmaceutical Corporation | Metal complexed serine protease inhibitors |
| US6255091B1 (en) | 1995-04-28 | 2001-07-03 | Axys Pharmaceuticals, Inc. | Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions |
| US6369235B1 (en) | 1997-02-25 | 2002-04-09 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted benzimidazoles, and methods of use thereof, for the inhibition of HIV reverse transcription and for the treatment of HIV infection |
| US5935982A (en) * | 1997-02-28 | 1999-08-10 | The University Of North Carolina At Chapel Hill | Methods of treating retroviral infection and compounds useful therefor |
| KR20010006119A (ko) * | 1997-04-07 | 2001-01-26 | 액시스 파마슈티컬스 인코포레이티드 | 세린 프로테아제, 특히 트립타아제 활성과 관련된 질병을 치료하기 위한 화합물 및 조성물 |
| FR2766822B1 (fr) * | 1997-07-30 | 2001-02-23 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6150379A (en) * | 1997-11-26 | 2000-11-21 | Axys Pharmaceuticals, Inc. | Compounds and compositions as anticoagulants |
| WO1999026933A1 (en) * | 1997-11-26 | 1999-06-03 | Axys Pharmaceuticals, Inc. | Substituted amidinoaryl derivatives and their use as anticoagulants |
| NZ508101A (en) | 1998-04-10 | 2002-12-20 | Japan Tobacco Inc | Amidine compounds useful as factor Xa inhibitors and as anticoagulants |
| CA2372456C (en) * | 1999-05-13 | 2009-08-25 | Japan Science And Technology Corporation | Viral infection inhibitor targeting integrase n-terminal domain |
| JP2003501418A (ja) | 1999-06-04 | 2003-01-14 | エラン ファーマ インターナショナル，リミティド | 細胞死を阻害するための組成物および方法 |
| US6774144B1 (en) | 1999-11-01 | 2004-08-10 | The University Of North Carolina At Chapel Hill | Methods and formulations for the treatment of infectious bursal disease in avian subjects |
| AU1450401A (en) * | 1999-11-01 | 2001-05-14 | Auburn University | Methods and formulations for the treatment of infectious bursal disease in avian subjects |
| US7262223B2 (en) | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| EP2120952A4 (en) * | 2007-01-15 | 2011-09-21 | Us Of America As Represented By The Secretary Of The Army On Behalf Of The U S Army Res Inst Of Infe | ANTIVIRAL COMPOUNDS AND METHODS OF USE |
| CN101952310A (zh) * | 2007-10-24 | 2011-01-19 | 功能遗传学股份有限公司 | 抑制病毒性感染的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA708089B (en) * | 1969-12-29 | 1971-08-25 | Abbott Lab | Bis-benzimidazole derivatives |
| US4619942A (en) * | 1982-04-08 | 1986-10-28 | University Of North Carolina | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds |
| US4963589A (en) | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
| US4933347A (en) | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
| US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
| WO1995008540A1 (en) | 1993-09-22 | 1995-03-30 | The Wellcome Foundation Limited | Bis(amidinobenzimidazolyl)alkanes as antiviral agents |
-
1994
- 1994-01-20 US US08/185,079 patent/US6815461B1/en not_active Expired - Fee Related
-
1995
- 1995-01-18 WO PCT/US1995/000504 patent/WO1995019772A1/en not_active Ceased
- 1995-01-18 EP EP95908504A patent/EP0739202B1/en not_active Expired - Lifetime
- 1995-01-18 ES ES95908504T patent/ES2128043T3/es not_active Expired - Lifetime
- 1995-01-18 JP JP51960295A patent/JP3306830B2/ja not_active Expired - Fee Related
- 1995-01-18 DE DE69506686T patent/DE69506686T2/de not_active Expired - Fee Related
- 1995-01-18 NZ NZ279619A patent/NZ279619A/en unknown
- 1995-01-18 AU AU16798/95A patent/AU675386B2/en not_active Ceased
- 1995-01-18 NZ NZ335226A patent/NZ335226A/xx unknown
- 1995-01-18 AT AT95908504T patent/ATE174508T1/de not_active IP Right Cessation
- 1995-01-18 CA CA002179015A patent/CA2179015C/en not_active Expired - Fee Related
- 1995-01-18 BR BR9506552A patent/BR9506552A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0739202B1 (en) | 1998-12-16 |
| CA2179015A1 (en) | 1995-07-27 |
| WO1995019772A1 (en) | 1995-07-27 |
| JPH09508369A (ja) | 1997-08-26 |
| NZ335226A (en) | 2000-11-24 |
| AU675386B2 (en) | 1997-01-30 |
| DE69506686D1 (de) | 1999-01-28 |
| CA2179015C (en) | 2003-06-24 |
| US6815461B1 (en) | 2004-11-09 |
| ATE174508T1 (de) | 1999-01-15 |
| DE69506686T2 (de) | 1999-07-22 |
| BR9506552A (pt) | 1997-10-28 |
| EP0739202A1 (en) | 1996-10-30 |
| AU1679895A (en) | 1995-08-08 |
| NZ279619A (en) | 1999-09-29 |
| JP3306830B2 (ja) | 2002-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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