ATE174508T1 - Verwendung von bis (amidinobenzidazolen) zur herstellung eines medikamentes für die hemmung der retroviral integrase - Google Patents
Verwendung von bis (amidinobenzidazolen) zur herstellung eines medikamentes für die hemmung der retroviral integraseInfo
- Publication number
- ATE174508T1 ATE174508T1 AT95908504T AT95908504T ATE174508T1 AT E174508 T1 ATE174508 T1 AT E174508T1 AT 95908504 T AT95908504 T AT 95908504T AT 95908504 T AT95908504 T AT 95908504T AT E174508 T1 ATE174508 T1 AT E174508T1
- Authority
- AT
- Austria
- Prior art keywords
- bis
- amidinobenzidazole
- medication
- producing
- retroviral integrase
- Prior art date
Links
- 102100034343 Integrase Human genes 0.000 title abstract 3
- 108010061833 Integrases Proteins 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 3
- 230000001177 retroviral effect Effects 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- QZKOOEFIMWKZPK-UHFFFAOYSA-N 2-[(6-carbamimidoyl-1h-benzimidazol-2-yl)methyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(CC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 QZKOOEFIMWKZPK-UHFFFAOYSA-N 0.000 abstract 1
- DFFCDIMSXJYMTB-UHFFFAOYSA-N 2-[2-(6-carbamimidoyl-1h-benzimidazol-2-yl)ethenyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(C=CC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 DFFCDIMSXJYMTB-UHFFFAOYSA-N 0.000 abstract 1
- KIYLEUCIWFUYOC-UHFFFAOYSA-N 2-[2-(6-carbamimidoyl-1h-benzimidazol-2-yl)ethyl]-3h-benzimidazole-5-carboximidamide Chemical compound C1=C(C(N)=N)C=C2NC(CCC3=NC4=CC=C(C=C4N3)C(=N)N)=NC2=C1 KIYLEUCIWFUYOC-UHFFFAOYSA-N 0.000 abstract 1
- 206010038997 Retroviral infections Diseases 0.000 abstract 1
- -1 bis-benzimidazole compound Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thin Film Transistor (AREA)
- Saccharide Compounds (AREA)
- Recrystallisation Techniques (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/185,079 US6815461B1 (en) | 1994-01-20 | 1994-01-20 | Method of inhibiting retroviral integrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174508T1 true ATE174508T1 (de) | 1999-01-15 |
Family
ID=22679488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95908504T ATE174508T1 (de) | 1994-01-20 | 1995-01-18 | Verwendung von bis (amidinobenzidazolen) zur herstellung eines medikamentes für die hemmung der retroviral integrase |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6815461B1 (de) |
| EP (1) | EP0739202B1 (de) |
| JP (1) | JP3306830B2 (de) |
| AT (1) | ATE174508T1 (de) |
| AU (1) | AU675386B2 (de) |
| BR (1) | BR9506552A (de) |
| CA (1) | CA2179015C (de) |
| DE (1) | DE69506686T2 (de) |
| ES (1) | ES2128043T3 (de) |
| NZ (2) | NZ335226A (de) |
| WO (1) | WO1995019772A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562854B2 (en) | 1994-12-14 | 2003-05-13 | Axys Pharmaceuticals, Inc. | Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders |
| US6255091B1 (en) | 1995-04-28 | 2001-07-03 | Axys Pharmaceuticals, Inc. | Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions |
| US5693515A (en) * | 1995-04-28 | 1997-12-02 | Arris Pharmaceutical Corporation | Metal complexed serine protease inhibitors |
| CA2281927C (en) | 1997-02-25 | 2004-01-27 | Christopher J. Michejda | Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase |
| US5935982A (en) * | 1997-02-28 | 1999-08-10 | The University Of North Carolina At Chapel Hill | Methods of treating retroviral infection and compounds useful therefor |
| HUP0001522A3 (en) * | 1997-04-07 | 2001-08-28 | Axys Pharmaceuticals Corp Sout | Benzoimidazole derivatives, process for producing them and pharmaceutical compositions containing them |
| FR2766822B1 (fr) * | 1997-07-30 | 2001-02-23 | Adir | Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6150379A (en) * | 1997-11-26 | 2000-11-21 | Axys Pharmaceuticals, Inc. | Compounds and compositions as anticoagulants |
| AU1608399A (en) * | 1997-11-26 | 1999-06-15 | Axys Pharmaceuticals, Inc. | Substituted amidinoaryl derivatives and their use as anticoagulants |
| SK15072000A3 (sk) | 1998-04-10 | 2001-08-06 | Japan Tobacco Inc. | Amidové zlúčeniny |
| DK1176193T3 (da) * | 1999-05-13 | 2012-09-10 | Japan Science & Tech Agency | Hæmmere af virusinfektion, som angriber den n-terminale region af integrase |
| AU5314900A (en) | 1999-06-04 | 2000-12-28 | Elan Pharma International Limited | Compositions and methods for inhibiting cell death |
| US6774144B1 (en) | 1999-11-01 | 2004-08-10 | The University Of North Carolina At Chapel Hill | Methods and formulations for the treatment of infectious bursal disease in avian subjects |
| AU1450401A (en) * | 1999-11-01 | 2001-05-14 | Auburn University | Methods and formulations for the treatment of infectious bursal disease in avian subjects |
| US7262223B2 (en) | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| US7999001B2 (en) * | 2007-01-15 | 2011-08-16 | The United States Of America As Represented By The Secretary Of The Army | Antiviral compounds and methods of using thereof |
| EP2207801B1 (de) * | 2007-10-24 | 2013-04-17 | Functional Genetics, Inc. | Verfahren zur hemmung viraler infektionen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA708089B (en) * | 1969-12-29 | 1971-08-25 | Abbott Lab | Bis-benzimidazole derivatives |
| US4619942A (en) * | 1982-04-08 | 1986-10-28 | University Of North Carolina | Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds |
| US4933347A (en) | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
| US4963589A (en) | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
| US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
| AU7661594A (en) | 1993-09-22 | 1995-04-10 | Glaxo Wellcome House | Bis(amidinobenzimidazolyl)alkanes as antiviral agents |
-
1994
- 1994-01-20 US US08/185,079 patent/US6815461B1/en not_active Expired - Fee Related
-
1995
- 1995-01-18 BR BR9506552A patent/BR9506552A/pt not_active Application Discontinuation
- 1995-01-18 WO PCT/US1995/000504 patent/WO1995019772A1/en not_active Ceased
- 1995-01-18 CA CA002179015A patent/CA2179015C/en not_active Expired - Fee Related
- 1995-01-18 NZ NZ335226A patent/NZ335226A/xx unknown
- 1995-01-18 DE DE69506686T patent/DE69506686T2/de not_active Expired - Fee Related
- 1995-01-18 EP EP95908504A patent/EP0739202B1/de not_active Expired - Lifetime
- 1995-01-18 AT AT95908504T patent/ATE174508T1/de not_active IP Right Cessation
- 1995-01-18 AU AU16798/95A patent/AU675386B2/en not_active Ceased
- 1995-01-18 JP JP51960295A patent/JP3306830B2/ja not_active Expired - Fee Related
- 1995-01-18 NZ NZ279619A patent/NZ279619A/en unknown
- 1995-01-18 ES ES95908504T patent/ES2128043T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09508369A (ja) | 1997-08-26 |
| WO1995019772A1 (en) | 1995-07-27 |
| EP0739202B1 (de) | 1998-12-16 |
| CA2179015A1 (en) | 1995-07-27 |
| ES2128043T3 (es) | 1999-05-01 |
| NZ279619A (en) | 1999-09-29 |
| DE69506686T2 (de) | 1999-07-22 |
| AU1679895A (en) | 1995-08-08 |
| JP3306830B2 (ja) | 2002-07-24 |
| CA2179015C (en) | 2003-06-24 |
| DE69506686D1 (de) | 1999-01-28 |
| BR9506552A (pt) | 1997-10-28 |
| AU675386B2 (en) | 1997-01-30 |
| US6815461B1 (en) | 2004-11-09 |
| NZ335226A (en) | 2000-11-24 |
| EP0739202A1 (de) | 1996-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |