FR2455047A1 - Sels de 1-alkyl-9-bromo-hexahydroindoloquinolizinium, leur procede de preparation, et leur utilisation comme medicament et pour la synthese d'un ester d'acide 10-bromo vincaminique - Google Patents

Sels de 1-alkyl-9-bromo-hexahydroindoloquinolizinium, leur procede de preparation, et leur utilisation comme medicament et pour la synthese d'un ester d'acide 10-bromo vincaminique

Info

Publication number
FR2455047A1
FR2455047A1 FR8010639A FR8010639A FR2455047A1 FR 2455047 A1 FR2455047 A1 FR 2455047A1 FR 8010639 A FR8010639 A FR 8010639A FR 8010639 A FR8010639 A FR 8010639A FR 2455047 A1 FR2455047 A1 FR 2455047A1
Authority
FR
France
Prior art keywords
bromo
synthesis
alkyl
hexahydroindoloquinolizinium
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8010639A
Other languages
English (en)
Other versions
FR2455047B1 (fr
Inventor
Csaba Szantay
Lajos Szabo
Gyorgy Kalaus
Lajos Dancsi
Tibor Keve
Egon Karpati
Laszlo Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HURI000674 external-priority patent/HU177503B/hu
Priority claimed from HURI000672 external-priority patent/HU177502B/hu
Priority claimed from HURI000673 external-priority patent/HU177727B/hu
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of FR2455047A1 publication Critical patent/FR2455047A1/fr
Application granted granted Critical
Publication of FR2455047B1 publication Critical patent/FR2455047B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Abstract

SELS DE 1-ALKYL-9-BROMO-HEXAHYDROINDOLOQUINOLIZINIUM, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION COMME MEDICAMENT ET POUR LA SYNTHESE D'UN ESTER D'ACIDE 10-BROMO VINCAMINIQUE. (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN GROUPE ALKYLE CONTENANT 1 A 6ATOMES DE CARBONE ET A EST L'ANION D'UN ACIDE, OU UNE BASE LIBRE CORRESPONDANTE. CES COMPOSES SONT UTILISABLES COMME MEDICAMENT ET POUR LA SYNTHESE D'ESTERS D'ACIDE 10-BROMO-VINCAMINIQUES.
FR8010639A 1978-07-12 1980-05-12 Sels de 1-alkyl-9-bromo-hexahydroindoloquinolizinium, leur procede de preparation, et leur utilisation comme medicament et pour la synthese d'un ester d'acide 10-bromo vincaminique Granted FR2455047A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HURI000674 HU177503B (hu) 1978-07-12 1978-07-12 Szabadalmi leírás szolgálati találmány
HURI000672 HU177502B (hu) 1978-07-12 1978-07-12 Eljárás 9-bróm-l-alkil-hexahidro-indolo|2,3-alkinolizin-származékok előállítására
HURI000673 HU177727B (en) 1978-07-12 1978-07-12 Process for preparing 9-halo-1-alkyl-hexahydro-indolo/2,3-a/quinolizine derivatives
HURI000675 1978-07-12

Publications (2)

Publication Number Publication Date
FR2455047A1 true FR2455047A1 (fr) 1980-11-21
FR2455047B1 FR2455047B1 (fr) 1983-07-18

Family

ID=27452004

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7918055A Granted FR2431496A1 (fr) 1978-07-12 1979-07-11 Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues
FR8010639A Granted FR2455047A1 (fr) 1978-07-12 1980-05-12 Sels de 1-alkyl-9-bromo-hexahydroindoloquinolizinium, leur procede de preparation, et leur utilisation comme medicament et pour la synthese d'un ester d'acide 10-bromo vincaminique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7918055A Granted FR2431496A1 (fr) 1978-07-12 1979-07-11 Procede pour la preparation d'esters d'acide 10-bromo-vincaminique et de composes analogues

Country Status (5)

Country Link
US (2) US4315011A (fr)
CH (3) CH653996A5 (fr)
DE (1) DE2928219A1 (fr)
FR (2) FR2431496A1 (fr)
GB (2) GB2036732B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315011A (en) * 1978-07-12 1982-02-09 Richter Gedeon Vegyeszeti Gyar Rt. 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow
HU177732B (en) * 1978-12-15 1981-12-28 Richter Gedeon Vegyeszet Process for producing 10-bromo-vincamine and acid additional salts thereof,and 10-bromo-14-epivincamine
HU181484B (en) * 1979-10-30 1983-07-28 Richter Gedeon Vegyeszet Process for preparing 11-bromo-15-hydroxyimino-e-homo-eburnane derivatives
HU181941B (en) * 1979-11-23 1983-11-28 Richter Gedeon Vegyeszet Process for producing apovincaminic acid ester derivatives
HU185305B (en) * 1981-08-23 1985-01-28 Richter Gedeon Vegyeszet Process for preparing vincine and apovincine
HU190400B (en) * 1982-06-30 1986-08-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing new eburnan-oxime derivatives
JP2851133B2 (ja) * 1989-06-21 1999-01-27 リヒター ゲデオン ベジェセティ ジャール アール．テー． 新規ラセミ及び光学的活性オクタヒドロ―インド―ロ〔２，３―ａ〕テトラヒドロピラニル〔２，３―ｃ〕キノリジンジエステル誘導体及びその調製方法
SE9802974D0 (sv) * 1998-09-03 1998-09-03 Astra Ab New crystalline forms

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2197873A1 (fr) * 1972-09-06 1974-03-29 Richter Gedeon Vegyeszet
FR2444037A1 (fr) * 1978-12-15 1980-07-11 Richter Gedeon Vegyeszet Procede de preparation de 10-bromovincamines et composes obtenus

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1266201B (de) * 1966-01-11 1968-04-11 Sigri Elektrographit Gmbh Kohle- oder Graphitkoerper mit einer darauf aufgebrachten oxydationshemmenden Schutzschicht, sowie Verfahren zu dessen Herstellung
US3770724A (en) * 1970-03-31 1973-11-06 Roussel Uclaf Process for preparing pentacyclic alkaloids
FR2081593A1 (en) * 1970-03-31 1971-12-10 Roussel Uclaf Vincamine process
FR2104959A2 (en) * 1970-09-10 1972-04-28 Roussel Uclaf Vincamine process
DE2163657A1 (de) * 1970-12-22 1972-07-13 Yoshitomi Pharmaceutical Industries Ltd., Osaka (Japan) N-substituierte Piperidinverbindungen
FR2121360B1 (fr) * 1971-01-06 1974-03-22 Roussel Uclaf
HU163143B (fr) * 1971-05-07 1973-06-28
FR2168853B1 (fr) * 1972-01-24 1975-04-25 Centre Etd Ind Pharma
US4146643A (en) * 1973-12-18 1979-03-27 Sandoz Ltd. Increasing vigilance or treating cerebral insufficiency with substituted vincamines
DK139358B (da) * 1973-12-18 1979-02-05 Sandoz Ag Analogifremgangsmåde til fremstilling af vincaminderivater eller syreadditionssalte deraf.
AU499923B2 (en) * 1975-06-27 1979-05-03 Richter Gedeon Vegyeszeti Gyar N Indoloquinolizine derivatives & their production
US4156969A (en) * 1976-11-19 1979-06-05 Werber Fred W K R Garment designing aid
FR2445328A1 (fr) * 1978-07-12 1980-07-25 Richter Gedeon Vegyeszet Derives du 14-oxo-e-homo-eburnane, leur procede de preparation et leur utilisation comme medicament
US4315011A (en) * 1978-07-12 1982-02-09 Richter Gedeon Vegyeszeti Gyar Rt. 1-Alkyl-9-bromohexahydroindolo quinolizium salts and use thereof to increase blood flow

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2197873A1 (fr) * 1972-09-06 1974-03-29 Richter Gedeon Vegyeszet
FR2444037A1 (fr) * 1978-12-15 1980-07-11 Richter Gedeon Vegyeszet Procede de preparation de 10-bromovincamines et composes obtenus

Also Published As

Publication number Publication date
GB2106504B (en) 1983-08-03
CH649999A5 (de) 1985-06-28
US4456607A (en) 1984-06-26
FR2431496B1 (fr) 1983-07-29
FR2455047B1 (fr) 1983-07-18
CH654007A5 (de) 1986-01-31
FR2431496A1 (fr) 1980-02-15
US4315011A (en) 1982-02-09
DE2928219A1 (de) 1980-01-24
CH653996A5 (de) 1986-01-31
GB2106504A (en) 1983-04-13
GB2036732A (en) 1980-07-02
GB2036732B (en) 1983-05-11

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