FR2447913A1 - Procede de fabrication de la n-(4' pyridyl)-3,3-diphenylpropylamine - Google Patents
Procede de fabrication de la n-(4' pyridyl)-3,3-diphenylpropylamineInfo
- Publication number
- FR2447913A1 FR2447913A1 FR8001900A FR8001900A FR2447913A1 FR 2447913 A1 FR2447913 A1 FR 2447913A1 FR 8001900 A FR8001900 A FR 8001900A FR 8001900 A FR8001900 A FR 8001900A FR 2447913 A1 FR2447913 A1 FR 2447913A1
- Authority
- FR
- France
- Prior art keywords
- phenyl
- prepn
- propylamine
- pyridyl
- spasmolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000812 cholinergic antagonist Substances 0.000 title abstract 2
- 230000002048 spasmolytic effect Effects 0.000 title abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- MFEILWXBDBCWKF-UHFFFAOYSA-N 3-phenylpropanoyl chloride Chemical compound ClC(=O)CCC1=CC=CC=C1 MFEILWXBDBCWKF-UHFFFAOYSA-N 0.000 title 1
- LYUQWQRTDLVQGA-UHFFFAOYSA-N 3-phenylpropylamine Chemical compound NCCCC1=CC=CC=C1 LYUQWQRTDLVQGA-UHFFFAOYSA-N 0.000 title 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000010 aprotic solvent Substances 0.000 abstract 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 abstract 1
- BZQGAPWJKAYCHR-UHFFFAOYSA-N 3,3-diphenylpropanoic acid Chemical compound C=1C=CC=CC=1C(CC(=O)O)C1=CC=CC=C1 BZQGAPWJKAYCHR-UHFFFAOYSA-N 0.000 abstract 1
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 abstract 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 abstract 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 229910010084 LiAlH4 Inorganic materials 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229930016911 cinnamic acid Natural products 0.000 abstract 1
- 235000013985 cinnamic acid Nutrition 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 229960004979 fampridine Drugs 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19708/79A IT1162708B (it) | 1979-01-30 | 1979-01-30 | Procedimento di preparazione della n-(4'-piridil)-3,3-difenilpropilammina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2447913A1 true FR2447913A1 (fr) | 1980-08-29 |
| FR2447913B1 FR2447913B1 (enExample) | 1983-12-09 |
Family
ID=11160556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8001900A Granted FR2447913A1 (fr) | 1979-01-30 | 1980-01-29 | Procede de fabrication de la n-(4' pyridyl)-3,3-diphenylpropylamine |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS603386B2 (enExample) |
| BE (1) | BE881319A (enExample) |
| DE (1) | DE3002909A1 (enExample) |
| ES (1) | ES488375A0 (enExample) |
| FR (1) | FR2447913A1 (enExample) |
| IT (1) | IT1162708B (enExample) |
| NL (1) | NL8000490A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2465723A1 (fr) * | 1979-05-30 | 1981-03-27 | Italiana Schoum Spa | Nouvelles diphenylpropylamino-pyridines utilisables comme medicaments |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1167197B (it) * | 1983-07-25 | 1987-05-13 | Bellon Roger Schoum Rbs Pharma | Impiego della fenpiramina quale farmaco antiaggregante piastrinico,vasodilatatore,antitrombotico e antianginoso |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180670A (en) * | 1977-02-02 | 1979-12-25 | John Wyeth & Brother Limited | Amino pyridine derivatives |
-
1979
- 1979-01-30 IT IT19708/79A patent/IT1162708B/it active
-
1980
- 1980-01-10 JP JP55001734A patent/JPS603386B2/ja not_active Expired
- 1980-01-24 BE BE2/58364A patent/BE881319A/fr not_active IP Right Cessation
- 1980-01-25 NL NL8000490A patent/NL8000490A/nl not_active Application Discontinuation
- 1980-01-28 DE DE19803002909 patent/DE3002909A1/de not_active Ceased
- 1980-01-29 FR FR8001900A patent/FR2447913A1/fr active Granted
- 1980-01-30 ES ES488375A patent/ES488375A0/es active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4180670A (en) * | 1977-02-02 | 1979-12-25 | John Wyeth & Brother Limited | Amino pyridine derivatives |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2465723A1 (fr) * | 1979-05-30 | 1981-03-27 | Italiana Schoum Spa | Nouvelles diphenylpropylamino-pyridines utilisables comme medicaments |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS603386B2 (ja) | 1985-01-28 |
| IT7919708A0 (it) | 1979-01-30 |
| DE3002909A1 (de) | 1980-07-31 |
| NL8000490A (nl) | 1980-08-01 |
| FR2447913B1 (enExample) | 1983-12-09 |
| JPS55102565A (en) | 1980-08-05 |
| ES8101553A1 (es) | 1980-12-16 |
| BE881319A (fr) | 1980-05-16 |
| IT1162708B (it) | 1987-04-01 |
| ES488375A0 (es) | 1980-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CD | Change of name or company name | ||
| ST | Notification of lapse |